Rehmannia glutinosa polysaccharides: a review on structure-activity relationship and biological activity
Rehmannia glutinosa has been used historically and is now listed in the 2020 Chinese Pharmacopoeia as a traditional Chinese medicine for nourishing yin and tonifying kidney. Polysaccharides are one of the main active ingredients in Rehmannia glutinosa . In recent years, Rehmannia glutinosa polysacch...
Gespeichert in:
| Veröffentlicht in: | Medicinal chemistry research 2024-02, Vol.33 (2), p.254-267 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 267 |
|---|---|
| container_issue | 2 |
| container_start_page | 254 |
| container_title | Medicinal chemistry research |
| container_volume | 33 |
| creator | Cao, Qianqian Wang, Zhixuan Jiang, Youning Dong, Chunhong |
| description | Rehmannia glutinosa
has been used historically and is now listed in the 2020 Chinese Pharmacopoeia as a traditional Chinese medicine for nourishing yin and tonifying kidney. Polysaccharides are one of the main active ingredients in
Rehmannia glutinosa
. In recent years,
Rehmannia glutinosa
polysaccharides have received widespread attention due to their various biological activities such as immune regulation, anti-tumor, antioxidant and anti-aging. Many studies have mainly focused on the extraction and biological activity of crude polysaccharides from
Rehmannia glutinosa
. However, the structure and biological activity of purified polysaccharides may differ from that of crude polysaccharides. To date, more than 20 kinds of polysaccharides have been isolated and purified from
Rehmannia glutinosa
, which are mainly composed of arabinose, rhamnose, galactose, glucose, mannose, xylose, fucose, and galactonic acid. However, the structure-activity relationship of
Rehmannia glutinosa
polysaccharides has not been well determined. This review summarizes the structural characteristics of purified polysaccharides from
Rehmannia glutinosa
and explores their structure-activity relationships. Finally, we emphasized some key mechanisms and pathways of biological activity. This article will lay the foundation for the future development and clinical application research of functional products of
Rehmannia glutinosa
. It also has certain guiding significance for the development and application of traditional Chinese medicine resources of
Rehmannia glutinosa
. |
| doi_str_mv | 10.1007/s00044-023-03183-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2917581867</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2917581867</sourcerecordid><originalsourceid>FETCH-LOGICAL-c270t-db538bbdae176ee8194e8417e3e1b99a41f399439683718ee4d3d17511d4b2c3</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhosouK7-AU8Bz9F8dZN6k8UvEATZe0jT2W2WblKTdqX_3ugq3jzNC_O8M_AUxSUl15QQeZMIIUJgwjgmnCqOp6NiRstSYEUZOc6Z5MxKxk-Ls5S2hHBJRDkr2jdod8Z7Z9CmGwfnQzKoD92UjLWtia6BdIsMirB38IGCR2mIox3GCNjYwe3dMOVlZwYXfGpdj4xvUO1CFzbOmg79QufFydp0CS5-5rxYPdyvlk_45fXxeXn3gi2TZMBNXXJV140BKhcAilYClKASONC6qoyga15VglcLxSVVAKLhDZUlpY2omeXz4upwto_hfYQ06G0Yo88fNasyp6hayEyxA2VjSCnCWvfR7UycNCX6S6g-CNVZqP4Wqqdc4odSyrDfQPw7_U_rE46se2s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2917581867</pqid></control><display><type>article</type><title>Rehmannia glutinosa polysaccharides: a review on structure-activity relationship and biological activity</title><source>SpringerLink Journals</source><creator>Cao, Qianqian ; Wang, Zhixuan ; Jiang, Youning ; Dong, Chunhong</creator><creatorcontrib>Cao, Qianqian ; Wang, Zhixuan ; Jiang, Youning ; Dong, Chunhong</creatorcontrib><description>Rehmannia glutinosa
has been used historically and is now listed in the 2020 Chinese Pharmacopoeia as a traditional Chinese medicine for nourishing yin and tonifying kidney. Polysaccharides are one of the main active ingredients in
Rehmannia glutinosa
. In recent years,
Rehmannia glutinosa
polysaccharides have received widespread attention due to their various biological activities such as immune regulation, anti-tumor, antioxidant and anti-aging. Many studies have mainly focused on the extraction and biological activity of crude polysaccharides from
Rehmannia glutinosa
. However, the structure and biological activity of purified polysaccharides may differ from that of crude polysaccharides. To date, more than 20 kinds of polysaccharides have been isolated and purified from
Rehmannia glutinosa
, which are mainly composed of arabinose, rhamnose, galactose, glucose, mannose, xylose, fucose, and galactonic acid. However, the structure-activity relationship of
Rehmannia glutinosa
polysaccharides has not been well determined. This review summarizes the structural characteristics of purified polysaccharides from
Rehmannia glutinosa
and explores their structure-activity relationships. Finally, we emphasized some key mechanisms and pathways of biological activity. This article will lay the foundation for the future development and clinical application research of functional products of
Rehmannia glutinosa
. It also has certain guiding significance for the development and application of traditional Chinese medicine resources of
Rehmannia glutinosa
.</description><identifier>ISSN: 1054-2523</identifier><identifier>EISSN: 1554-8120</identifier><identifier>DOI: 10.1007/s00044-023-03183-y</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Arabinose ; Biochemistry ; Biological activity ; Biomedical and Life Sciences ; Biomedicine ; Bioorganic Chemistry ; Chinese medicine ; Galactonic acid ; Galactose ; Immunoregulation ; Inorganic Chemistry ; Mannose ; Medicinal Chemistry ; Pharmacology/Toxicology ; Polysaccharides ; Rehmannia glutinosa ; Review Article ; Structure-activity relationships ; Traditional Chinese medicine</subject><ispartof>Medicinal chemistry research, 2024-02, Vol.33 (2), p.254-267</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c270t-db538bbdae176ee8194e8417e3e1b99a41f399439683718ee4d3d17511d4b2c3</cites><orcidid>0009-0003-7653-5909</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00044-023-03183-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00044-023-03183-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Cao, Qianqian</creatorcontrib><creatorcontrib>Wang, Zhixuan</creatorcontrib><creatorcontrib>Jiang, Youning</creatorcontrib><creatorcontrib>Dong, Chunhong</creatorcontrib><title>Rehmannia glutinosa polysaccharides: a review on structure-activity relationship and biological activity</title><title>Medicinal chemistry research</title><addtitle>Med Chem Res</addtitle><description>Rehmannia glutinosa
has been used historically and is now listed in the 2020 Chinese Pharmacopoeia as a traditional Chinese medicine for nourishing yin and tonifying kidney. Polysaccharides are one of the main active ingredients in
Rehmannia glutinosa
. In recent years,
Rehmannia glutinosa
polysaccharides have received widespread attention due to their various biological activities such as immune regulation, anti-tumor, antioxidant and anti-aging. Many studies have mainly focused on the extraction and biological activity of crude polysaccharides from
Rehmannia glutinosa
. However, the structure and biological activity of purified polysaccharides may differ from that of crude polysaccharides. To date, more than 20 kinds of polysaccharides have been isolated and purified from
Rehmannia glutinosa
, which are mainly composed of arabinose, rhamnose, galactose, glucose, mannose, xylose, fucose, and galactonic acid. However, the structure-activity relationship of
Rehmannia glutinosa
polysaccharides has not been well determined. This review summarizes the structural characteristics of purified polysaccharides from
Rehmannia glutinosa
and explores their structure-activity relationships. Finally, we emphasized some key mechanisms and pathways of biological activity. This article will lay the foundation for the future development and clinical application research of functional products of
Rehmannia glutinosa
. It also has certain guiding significance for the development and application of traditional Chinese medicine resources of
Rehmannia glutinosa
.</description><subject>Arabinose</subject><subject>Biochemistry</subject><subject>Biological activity</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>Chinese medicine</subject><subject>Galactonic acid</subject><subject>Galactose</subject><subject>Immunoregulation</subject><subject>Inorganic Chemistry</subject><subject>Mannose</subject><subject>Medicinal Chemistry</subject><subject>Pharmacology/Toxicology</subject><subject>Polysaccharides</subject><subject>Rehmannia glutinosa</subject><subject>Review Article</subject><subject>Structure-activity relationships</subject><subject>Traditional Chinese medicine</subject><issn>1054-2523</issn><issn>1554-8120</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhosouK7-AU8Bz9F8dZN6k8UvEATZe0jT2W2WblKTdqX_3ugq3jzNC_O8M_AUxSUl15QQeZMIIUJgwjgmnCqOp6NiRstSYEUZOc6Z5MxKxk-Ls5S2hHBJRDkr2jdod8Z7Z9CmGwfnQzKoD92UjLWtia6BdIsMirB38IGCR2mIox3GCNjYwe3dMOVlZwYXfGpdj4xvUO1CFzbOmg79QufFydp0CS5-5rxYPdyvlk_45fXxeXn3gi2TZMBNXXJV140BKhcAilYClKASONC6qoyga15VglcLxSVVAKLhDZUlpY2omeXz4upwto_hfYQ06G0Yo88fNasyp6hayEyxA2VjSCnCWvfR7UycNCX6S6g-CNVZqP4Wqqdc4odSyrDfQPw7_U_rE46se2s</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Cao, Qianqian</creator><creator>Wang, Zhixuan</creator><creator>Jiang, Youning</creator><creator>Dong, Chunhong</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><orcidid>https://orcid.org/0009-0003-7653-5909</orcidid></search><sort><creationdate>20240201</creationdate><title>Rehmannia glutinosa polysaccharides: a review on structure-activity relationship and biological activity</title><author>Cao, Qianqian ; Wang, Zhixuan ; Jiang, Youning ; Dong, Chunhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c270t-db538bbdae176ee8194e8417e3e1b99a41f399439683718ee4d3d17511d4b2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Arabinose</topic><topic>Biochemistry</topic><topic>Biological activity</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bioorganic Chemistry</topic><topic>Chinese medicine</topic><topic>Galactonic acid</topic><topic>Galactose</topic><topic>Immunoregulation</topic><topic>Inorganic Chemistry</topic><topic>Mannose</topic><topic>Medicinal Chemistry</topic><topic>Pharmacology/Toxicology</topic><topic>Polysaccharides</topic><topic>Rehmannia glutinosa</topic><topic>Review Article</topic><topic>Structure-activity relationships</topic><topic>Traditional Chinese medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cao, Qianqian</creatorcontrib><creatorcontrib>Wang, Zhixuan</creatorcontrib><creatorcontrib>Jiang, Youning</creatorcontrib><creatorcontrib>Dong, Chunhong</creatorcontrib><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Medicinal chemistry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cao, Qianqian</au><au>Wang, Zhixuan</au><au>Jiang, Youning</au><au>Dong, Chunhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rehmannia glutinosa polysaccharides: a review on structure-activity relationship and biological activity</atitle><jtitle>Medicinal chemistry research</jtitle><stitle>Med Chem Res</stitle><date>2024-02-01</date><risdate>2024</risdate><volume>33</volume><issue>2</issue><spage>254</spage><epage>267</epage><pages>254-267</pages><issn>1054-2523</issn><eissn>1554-8120</eissn><abstract>Rehmannia glutinosa
has been used historically and is now listed in the 2020 Chinese Pharmacopoeia as a traditional Chinese medicine for nourishing yin and tonifying kidney. Polysaccharides are one of the main active ingredients in
Rehmannia glutinosa
. In recent years,
Rehmannia glutinosa
polysaccharides have received widespread attention due to their various biological activities such as immune regulation, anti-tumor, antioxidant and anti-aging. Many studies have mainly focused on the extraction and biological activity of crude polysaccharides from
Rehmannia glutinosa
. However, the structure and biological activity of purified polysaccharides may differ from that of crude polysaccharides. To date, more than 20 kinds of polysaccharides have been isolated and purified from
Rehmannia glutinosa
, which are mainly composed of arabinose, rhamnose, galactose, glucose, mannose, xylose, fucose, and galactonic acid. However, the structure-activity relationship of
Rehmannia glutinosa
polysaccharides has not been well determined. This review summarizes the structural characteristics of purified polysaccharides from
Rehmannia glutinosa
and explores their structure-activity relationships. Finally, we emphasized some key mechanisms and pathways of biological activity. This article will lay the foundation for the future development and clinical application research of functional products of
Rehmannia glutinosa
. It also has certain guiding significance for the development and application of traditional Chinese medicine resources of
Rehmannia glutinosa
.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s00044-023-03183-y</doi><tpages>14</tpages><orcidid>https://orcid.org/0009-0003-7653-5909</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1054-2523 |
| ispartof | Medicinal chemistry research, 2024-02, Vol.33 (2), p.254-267 |
| issn | 1054-2523 1554-8120 |
| language | eng |
| recordid | cdi_proquest_journals_2917581867 |
| source | SpringerLink Journals |
| subjects | Arabinose Biochemistry Biological activity Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Chinese medicine Galactonic acid Galactose Immunoregulation Inorganic Chemistry Mannose Medicinal Chemistry Pharmacology/Toxicology Polysaccharides Rehmannia glutinosa Review Article Structure-activity relationships Traditional Chinese medicine |
| title | Rehmannia glutinosa polysaccharides: a review on structure-activity relationship and biological activity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T13%3A39%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Rehmannia%20glutinosa%20polysaccharides:%20a%20review%20on%20structure-activity%20relationship%20and%20biological%20activity&rft.jtitle=Medicinal%20chemistry%20research&rft.au=Cao,%20Qianqian&rft.date=2024-02-01&rft.volume=33&rft.issue=2&rft.spage=254&rft.epage=267&rft.pages=254-267&rft.issn=1054-2523&rft.eissn=1554-8120&rft_id=info:doi/10.1007/s00044-023-03183-y&rft_dat=%3Cproquest_cross%3E2917581867%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2917581867&rft_id=info:pmid/&rfr_iscdi=true |