Indazole derivatives as selective inhibitors of butyrylcholinesterase with effective blood-brain-barrier permeability profile

Alzheimer’s disease (AD) is a chronic disease that is multifactorial. Its underlying cause and mechanisms are yet to be fully understood and numerous research are underway to develop more effective drug candidates. This research explores the synthesis of an indazole-containing novel drug targeting A...

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Veröffentlicht in:Medicinal chemistry research 2024-02, Vol.33 (2), p.298-307
Hauptverfasser: Tobuse, Asuka Joy, Law, Christine Shing Wei, Thy, Chun Keng, James, Jason Jonah, Chee, Chin Fei, Yeong, Keng Yoon
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Sprache:eng
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