Adjuvant Effects of Deleting Hypervariable Domains of FliC of Escherichia coli Nissle 1917

Bacterial flagellin (FliC) can be used as a TLR5 ligand-like adjuvant. However, the sequences of hypervariable regions(HVR) of FliC from different bacteria vary, and their effects on adjuvants remain unclear. In this study, FliC Δ274–406 (deleting of D3 domain) and FliC Δ174–506 (deleting of D2-D3 d...

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Veröffentlicht in:	Molecular genetics, microbiology and virology microbiology and virology, 2023-09, Vol.38 (3), p.207-214
Hauptverfasser:	Li, Shuang, Deng, Yongjun, Ou, Bingming, Wen, Ming, Yang, Ying, Wen, Guilan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Affinity chromatography Antigenicity Biomedical and Life Sciences E coli Enzyme-linked immunosorbent assay Escherichia coli Experimental Papers Flagellin Immunogenicity Inclusion bodies Life Sciences Microbiology Molecular Medicine TLR5 protein Toll-like receptors Western blotting
Online-Zugang:	Volltext
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