Voltammetric study in aqueous media of two new sulfonylhydrazone derivatives as candidates for antichagasic drugs
Two new sulfonylhydrazone derivatives with potentially antichagasic biological activity, analogues of nitrofural, were studied by cyclic voltammetry in aqueous medium using glassy carbon electrode aiming at a better understanding of their redox mechanism that can be related to the biological mechani...
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| Veröffentlicht in: | Journal of applied electrochemistry 2024, Vol.54 (1), p.41-52 |
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| container_title | Journal of applied electrochemistry |
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| creator | de Almeida, Lígia Scandoglieri Chiavassa, Luísa Donatto de Lima Brito, Charles de Moura Gatti, Fernando Trossini, Gustavo Henrique Goulart La-Scalea, Mauro Aquiles |
| description | Two new sulfonylhydrazone derivatives with potentially antichagasic biological activity, analogues of nitrofural, were studied by cyclic voltammetry in aqueous medium using glassy carbon electrode aiming at a better understanding of their redox mechanism that can be related to the biological mechanism, being classically characterized by a charge transfer processes. In an acidic medium, an irreversible cathodic peak corresponding to the formation of a hydroxylamine derivative was observed, being linearly displaced with the decrease in the acidity of the medium to more negative potential values. In alkaline medium, the reduction was independent of the pH, registering the formation of the reversible R-NO
2
/R-NO
2
.
−
couple. The half-life of the radical nitro-anion was experimentally estimated and corroborated by simulation with Digisim.
Graphical abstract |
| doi_str_mv | 10.1007/s10800-023-01945-5 |
| format | Article |
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2
/R-NO
2
.
−
couple. The half-life of the radical nitro-anion was experimentally estimated and corroborated by simulation with Digisim.
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2
/R-NO
2
.
−
couple. The half-life of the radical nitro-anion was experimentally estimated and corroborated by simulation with Digisim.
Graphical abstract</description><subject>Aqueous solutions</subject><subject>Biological activity</subject><subject>Charge transfer</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Electrochemistry</subject><subject>Glassy carbon</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Nitrogen dioxide</subject><subject>Physical Chemistry</subject><subject>Research Article</subject><subject>Voltammetry</subject><issn>0021-891X</issn><issn>1572-8838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMoWD_-gKeA59VJNtndHEX8AsGLircwzUfd0m5qkm2pv95oBW-ehoHnfYd5CDljcMEA2svEoAOogNcVMCVkJffIhMmWV11Xd_tkAsBZ1Sn2dkiOUpoDgOKNmJCP17DIuFy6HHtDUx7tlvYDxY_RhTHRpbM90uBp3gQ6uA1N48KHYbt439qIn2Fw1LrYrzH3a5coJmpwsL3FXDYfIsUh9-YdZ5hKvY3jLJ2QA4-L5E5_5zF5ub15vr6vHp_uHq6vHitTM5ErpiwXDWI9bVFMRculkLapRdeaAkinwCsuO2MUSIEcG-_BKNmg4Z01ztfH5HzXu4qhfJOynocxDuWk5ooxxhtes0LxHWViSCk6r1exX2Lcagb6W63eqdVFrf5Rq2UJ1btQKvAwc_Gv-p_UF-Jqfn8</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>de Almeida, Lígia Scandoglieri</creator><creator>Chiavassa, Luísa Donatto</creator><creator>de Lima Brito, Charles</creator><creator>de Moura Gatti, Fernando</creator><creator>Trossini, Gustavo Henrique Goulart</creator><creator>La-Scalea, Mauro Aquiles</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2024</creationdate><title>Voltammetric study in aqueous media of two new sulfonylhydrazone derivatives as candidates for antichagasic drugs</title><author>de Almeida, Lígia Scandoglieri ; Chiavassa, Luísa Donatto ; de Lima Brito, Charles ; de Moura Gatti, Fernando ; Trossini, Gustavo Henrique Goulart ; La-Scalea, Mauro Aquiles</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c314t-19d246aa3b7a4b472545d63487cc315e90f9258cc9054a2a6ff0c956ac28dcef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aqueous solutions</topic><topic>Biological activity</topic><topic>Charge transfer</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Electrochemistry</topic><topic>Glassy carbon</topic><topic>Industrial Chemistry/Chemical Engineering</topic><topic>Nitrogen dioxide</topic><topic>Physical Chemistry</topic><topic>Research Article</topic><topic>Voltammetry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Almeida, Lígia Scandoglieri</creatorcontrib><creatorcontrib>Chiavassa, Luísa Donatto</creatorcontrib><creatorcontrib>de Lima Brito, Charles</creatorcontrib><creatorcontrib>de Moura Gatti, Fernando</creatorcontrib><creatorcontrib>Trossini, Gustavo Henrique Goulart</creatorcontrib><creatorcontrib>La-Scalea, Mauro Aquiles</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of applied electrochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Almeida, Lígia Scandoglieri</au><au>Chiavassa, Luísa Donatto</au><au>de Lima Brito, Charles</au><au>de Moura Gatti, Fernando</au><au>Trossini, Gustavo Henrique Goulart</au><au>La-Scalea, Mauro Aquiles</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Voltammetric study in aqueous media of two new sulfonylhydrazone derivatives as candidates for antichagasic drugs</atitle><jtitle>Journal of applied electrochemistry</jtitle><stitle>J Appl Electrochem</stitle><date>2024</date><risdate>2024</risdate><volume>54</volume><issue>1</issue><spage>41</spage><epage>52</epage><pages>41-52</pages><issn>0021-891X</issn><eissn>1572-8838</eissn><abstract>Two new sulfonylhydrazone derivatives with potentially antichagasic biological activity, analogues of nitrofural, were studied by cyclic voltammetry in aqueous medium using glassy carbon electrode aiming at a better understanding of their redox mechanism that can be related to the biological mechanism, being classically characterized by a charge transfer processes. In an acidic medium, an irreversible cathodic peak corresponding to the formation of a hydroxylamine derivative was observed, being linearly displaced with the decrease in the acidity of the medium to more negative potential values. In alkaline medium, the reduction was independent of the pH, registering the formation of the reversible R-NO
2
/R-NO
2
.
−
couple. The half-life of the radical nitro-anion was experimentally estimated and corroborated by simulation with Digisim.
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| subjects | Aqueous solutions Biological activity Charge transfer Chemistry Chemistry and Materials Science Electrochemistry Glassy carbon Industrial Chemistry/Chemical Engineering Nitrogen dioxide Physical Chemistry Research Article Voltammetry |
| title | Voltammetric study in aqueous media of two new sulfonylhydrazone derivatives as candidates for antichagasic drugs |
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