Voltammetric study in aqueous media of two new sulfonylhydrazone derivatives as candidates for antichagasic drugs

Two new sulfonylhydrazone derivatives with potentially antichagasic biological activity, analogues of nitrofural, were studied by cyclic voltammetry in aqueous medium using glassy carbon electrode aiming at a better understanding of their redox mechanism that can be related to the biological mechanism, being classically characterized by a charge transfer processes. In an acidic medium, an irreversible cathodic peak corresponding to the formation of a hydroxylamine derivative was observed, being linearly displaced with the decrease in the acidity of the medium to more negative potential values. In alkaline medium, the reduction was independent of the pH, registering the formation of the reversible R-NO 2 /R-NO 2 . − couple. The half-life of the radical nitro-anion was experimentally estimated and corroborated by simulation with Digisim. Graphical abstract