Prevalence of MTHFR Gene (C677T and A1298C) Polymorphism in the Syrian Coastal Area
The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene mutations can reduce the activity of the enzyme, which has been shown to be a significant factor in the risk of developing certain types of cancer and numerous other diseases, including cardiovascular conditions, diabetes, ischemia, venous th...
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Veröffentlicht in: | Research journal of pharmacy and technology 2023-09, Vol.16 (9), p.4365-4369 |
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creator | Younes, Ariana Khaddour, Mazen Salloum, Mazen Samra, Suzan Akel, Samer |
description | The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene mutations can reduce the activity of the enzyme, which has been shown to be a significant factor in the risk of developing certain types of cancer and numerous other diseases, including cardiovascular conditions, diabetes, ischemia, venous thrombosis, hypotonia, and many others. This study aims to determine the frequency of the two most prevalent MTHFR gene polymorphisms, C677T and A1298C, in the Syrian coastal population. Real-time PCR is used to detect MTHFR gene variants in samples from seventy healthy males from Syrian Coastal Area. The frequency of the C/C, C/T, and T/T genotypes for the C677T polymorphism was 47.14 percent, 38.57 percent, and 14.29 percent, respectively. The overall carrier rate was 52.86%, and the allelic frequency was 0.336. The genotypic prevalence of A/A, A/C, and C/C for the A1298C polymorphism was 44.29%, 35.71%, and 20%, respectively, with an allelic frequency of 0.378, while the overall carrier rate was 55.71%. In conclusion, the high prevalence of the MTHFR A1298C polymorphism is a significant finding that must be investigated in terms of clinical implications and reveals an additional genetic trait unique to the Syrian coast population. |
doi_str_mv | 10.52711/0974-360X.2023.00714 |
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This study aims to determine the frequency of the two most prevalent MTHFR gene polymorphisms, C677T and A1298C, in the Syrian coastal population. Real-time PCR is used to detect MTHFR gene variants in samples from seventy healthy males from Syrian Coastal Area. The frequency of the C/C, C/T, and T/T genotypes for the C677T polymorphism was 47.14 percent, 38.57 percent, and 14.29 percent, respectively. The overall carrier rate was 52.86%, and the allelic frequency was 0.336. The genotypic prevalence of A/A, A/C, and C/C for the A1298C polymorphism was 44.29%, 35.71%, and 20%, respectively, with an allelic frequency of 0.378, while the overall carrier rate was 55.71%. In conclusion, the high prevalence of the MTHFR A1298C polymorphism is a significant finding that must be investigated in terms of clinical implications and reveals an additional genetic trait unique to the Syrian coast population.</description><identifier>ISSN: 0974-3618</identifier><identifier>EISSN: 0974-360X</identifier><identifier>EISSN: 0974-306X</identifier><identifier>DOI: 10.52711/0974-360X.2023.00714</identifier><language>eng</language><publisher>Raipur: A&V Publications</publisher><subject>Cancer ; Coasts ; Conflicts of interest ; Congenital diseases ; DNA methylation ; Enzymes ; Genotype & phenotype ; Homocysteine ; Investigations ; Minority & ethnic groups ; Mutation ; Polymorphism ; Statistical analysis ; Vitamin B ; White people</subject><ispartof>Research journal of pharmacy and technology, 2023-09, Vol.16 (9), p.4365-4369</ispartof><rights>Copyright A&V Publications Sep 2023</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c144t-8d18101344005447c675e23dd9f4bf7fd82ccfee16e545e5a2e75edec5eb5f303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Younes, Ariana</creatorcontrib><creatorcontrib>Khaddour, Mazen</creatorcontrib><creatorcontrib>Salloum, Mazen</creatorcontrib><creatorcontrib>Samra, Suzan</creatorcontrib><creatorcontrib>Akel, Samer</creatorcontrib><title>Prevalence of MTHFR Gene (C677T and A1298C) Polymorphism in the Syrian Coastal Area</title><title>Research journal of pharmacy and technology</title><description>The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene mutations can reduce the activity of the enzyme, which has been shown to be a significant factor in the risk of developing certain types of cancer and numerous other diseases, including cardiovascular conditions, diabetes, ischemia, venous thrombosis, hypotonia, and many others. This study aims to determine the frequency of the two most prevalent MTHFR gene polymorphisms, C677T and A1298C, in the Syrian coastal population. Real-time PCR is used to detect MTHFR gene variants in samples from seventy healthy males from Syrian Coastal Area. The frequency of the C/C, C/T, and T/T genotypes for the C677T polymorphism was 47.14 percent, 38.57 percent, and 14.29 percent, respectively. The overall carrier rate was 52.86%, and the allelic frequency was 0.336. The genotypic prevalence of A/A, A/C, and C/C for the A1298C polymorphism was 44.29%, 35.71%, and 20%, respectively, with an allelic frequency of 0.378, while the overall carrier rate was 55.71%. In conclusion, the high prevalence of the MTHFR A1298C polymorphism is a significant finding that must be investigated in terms of clinical implications and reveals an additional genetic trait unique to the Syrian coast population.</description><subject>Cancer</subject><subject>Coasts</subject><subject>Conflicts of interest</subject><subject>Congenital diseases</subject><subject>DNA methylation</subject><subject>Enzymes</subject><subject>Genotype & phenotype</subject><subject>Homocysteine</subject><subject>Investigations</subject><subject>Minority & ethnic groups</subject><subject>Mutation</subject><subject>Polymorphism</subject><subject>Statistical analysis</subject><subject>Vitamin B</subject><subject>White people</subject><issn>0974-3618</issn><issn>0974-360X</issn><issn>0974-306X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNo9kNFqwjAUhsPYYOJ8hEFgN9tF3UmaNOmllKkDx2Q62F2I7QlWauuSKvj2szo8N-dw-Ph_-Ah5ZDCUXDH2CqkSUZzAz5ADj4cAiokb0ru-b6830_dkEMIGTpNoyYXukcXc48FWWOdIG0c_ltPxF51gjfQ5S5RaUlsXdMR4qrMXOm-q47bxu3UZtrSsabtGujj60tY0a2xobUVHHu0DuXO2Cjj4333yPX5bZtNo9jl5z0azKGdCtJEumGbAYiEApBAqT5REHhdF6sTKKVdonucOkSUohURpOZ6AAnOJK-liiPvk6ZK7883vHkNrNs3e16dKw1NINaQgO0peqNw3IXh0ZufLrfVHw8CcFZrOj-lcmU6hOSuM_wB8PWCa</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Younes, Ariana</creator><creator>Khaddour, Mazen</creator><creator>Salloum, Mazen</creator><creator>Samra, Suzan</creator><creator>Akel, Samer</creator><general>A&V Publications</general><scope>AAYXX</scope><scope>CITATION</scope><scope>04Q</scope><scope>04S</scope><scope>04W</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20230901</creationdate><title>Prevalence of MTHFR Gene (C677T and A1298C) Polymorphism in the Syrian Coastal Area</title><author>Younes, Ariana ; Khaddour, Mazen ; Salloum, Mazen ; Samra, Suzan ; Akel, Samer</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c144t-8d18101344005447c675e23dd9f4bf7fd82ccfee16e545e5a2e75edec5eb5f303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cancer</topic><topic>Coasts</topic><topic>Conflicts of interest</topic><topic>Congenital diseases</topic><topic>DNA methylation</topic><topic>Enzymes</topic><topic>Genotype & phenotype</topic><topic>Homocysteine</topic><topic>Investigations</topic><topic>Minority & ethnic groups</topic><topic>Mutation</topic><topic>Polymorphism</topic><topic>Statistical analysis</topic><topic>Vitamin B</topic><topic>White people</topic><toplevel>online_resources</toplevel><creatorcontrib>Younes, Ariana</creatorcontrib><creatorcontrib>Khaddour, Mazen</creatorcontrib><creatorcontrib>Salloum, Mazen</creatorcontrib><creatorcontrib>Samra, Suzan</creatorcontrib><creatorcontrib>Akel, Samer</creatorcontrib><collection>CrossRef</collection><collection>India Database</collection><collection>India Database: Business</collection><collection>India Database: Science & Technology</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Research journal of pharmacy and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Younes, Ariana</au><au>Khaddour, Mazen</au><au>Salloum, Mazen</au><au>Samra, Suzan</au><au>Akel, Samer</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of MTHFR Gene (C677T and A1298C) Polymorphism in the Syrian Coastal Area</atitle><jtitle>Research journal of pharmacy and technology</jtitle><date>2023-09-01</date><risdate>2023</risdate><volume>16</volume><issue>9</issue><spage>4365</spage><epage>4369</epage><pages>4365-4369</pages><issn>0974-3618</issn><eissn>0974-360X</eissn><eissn>0974-306X</eissn><abstract>The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene mutations can reduce the activity of the enzyme, which has been shown to be a significant factor in the risk of developing certain types of cancer and numerous other diseases, including cardiovascular conditions, diabetes, ischemia, venous thrombosis, hypotonia, and many others. This study aims to determine the frequency of the two most prevalent MTHFR gene polymorphisms, C677T and A1298C, in the Syrian coastal population. Real-time PCR is used to detect MTHFR gene variants in samples from seventy healthy males from Syrian Coastal Area. The frequency of the C/C, C/T, and T/T genotypes for the C677T polymorphism was 47.14 percent, 38.57 percent, and 14.29 percent, respectively. The overall carrier rate was 52.86%, and the allelic frequency was 0.336. The genotypic prevalence of A/A, A/C, and C/C for the A1298C polymorphism was 44.29%, 35.71%, and 20%, respectively, with an allelic frequency of 0.378, while the overall carrier rate was 55.71%. In conclusion, the high prevalence of the MTHFR A1298C polymorphism is a significant finding that must be investigated in terms of clinical implications and reveals an additional genetic trait unique to the Syrian coast population.</abstract><cop>Raipur</cop><pub>A&V Publications</pub><doi>10.52711/0974-360X.2023.00714</doi><tpages>5</tpages></addata></record> |
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subjects | Cancer Coasts Conflicts of interest Congenital diseases DNA methylation Enzymes Genotype & phenotype Homocysteine Investigations Minority & ethnic groups Mutation Polymorphism Statistical analysis Vitamin B White people |
title | Prevalence of MTHFR Gene (C677T and A1298C) Polymorphism in the Syrian Coastal Area |
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