Supplementation of Spirulina platensis ethanol extract: influence on mRNA expression and prediction of molecular interactions with IL-10
Alleviation of inflammation requires an optimal balance between pro and anti-inflammatory cytokines, in which IL-10 plays a critical role as a major anti-inflammatory cytokine. Studies about the ability of the active component of Spirulina platensis to promote IL-10 expression still vary. This study...
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| Veröffentlicht in: | IOP conference series. Earth and environmental science 2023-12, Vol.1271 (1), p.12081 |
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| creator | Purba, H H S Paramita, R Prijanti, A R Iswanti, F C |
| description | Alleviation of inflammation requires an optimal balance between pro and anti-inflammatory cytokines, in which IL-10 plays a critical role as a major anti-inflammatory cytokine. Studies about the ability of the active component of
Spirulina platensis
to promote IL-10 expression still vary. This study aims to analyze the effect of
S. platensis
on IL-10 mRNA expression in healthy rats of emerging adults and young adults. This study used six groups of male Wistar rats aged 12, 18, and 24 weeks treated with 200 mg/kg BW of
S. platensis
extract and a control group. Molecular interaction was predicted between three bioactive compounds of
S. platensis
(α-glucan, β-carotene, phycocyanobilin) and tacrolimus (control ligand) with IL-10 protein. The relative expression ratio of IL-10 mRNA increased in the treatment rats at 12 weeks (1.77) and 24 weeks (2.05). In rats aged 18 weeks, there was no increase in the expression ratio of IL-10 mRNA in treated rats compared to controls (0.91). Tacrolimus, the control ligand, has the best affinity as an IL-10 inhibitor (-6.68 kcal/mol), followed by β-carotene (-5.83 kcal/mol). The ethanolic extract of
S. platensis
can potentially increase the expression of IL-10 mRNA in the rat spleen at 12 and 24 weeks. |
| doi_str_mv | 10.1088/1755-1315/1271/1/012081 |
| format | Article |
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Spirulina platensis
to promote IL-10 expression still vary. This study aims to analyze the effect of
S. platensis
on IL-10 mRNA expression in healthy rats of emerging adults and young adults. This study used six groups of male Wistar rats aged 12, 18, and 24 weeks treated with 200 mg/kg BW of
S. platensis
extract and a control group. Molecular interaction was predicted between three bioactive compounds of
S. platensis
(α-glucan, β-carotene, phycocyanobilin) and tacrolimus (control ligand) with IL-10 protein. The relative expression ratio of IL-10 mRNA increased in the treatment rats at 12 weeks (1.77) and 24 weeks (2.05). In rats aged 18 weeks, there was no increase in the expression ratio of IL-10 mRNA in treated rats compared to controls (0.91). Tacrolimus, the control ligand, has the best affinity as an IL-10 inhibitor (-6.68 kcal/mol), followed by β-carotene (-5.83 kcal/mol). The ethanolic extract of
S. platensis
can potentially increase the expression of IL-10 mRNA in the rat spleen at 12 and 24 weeks.</description><identifier>ISSN: 1755-1307</identifier><identifier>EISSN: 1755-1315</identifier><identifier>DOI: 10.1088/1755-1315/1271/1/012081</identifier><language>eng</language><publisher>Bristol: IOP Publishing</publisher><subject>Adults ; Bioactive compounds ; Carotene ; Cyanobacteria ; Cytokines ; Ethanol ; Gene expression ; Glucan ; IL-10 ; Inflammation ; Interleukin 10 ; Ligands ; molecular interaction ; Molecular interactions ; mRNA expression ; Phycocyanobilin ; rat spleen ; Spirulina platensis ; Tacrolimus ; Young adults ; β-Carotene</subject><ispartof>IOP conference series. Earth and environmental science, 2023-12, Vol.1271 (1), p.12081</ispartof><rights>Published under licence by IOP Publishing Ltd</rights><rights>Published under licence by IOP Publishing Ltd. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2731-62240fab0df089f8a4a98c64203db7907c5e41b572a0c0418f9c468b7042e863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://iopscience.iop.org/article/10.1088/1755-1315/1271/1/012081/pdf$$EPDF$$P50$$Giop$$Hfree_for_read</linktopdf><link.rule.ids>314,777,781,27905,27906,38849,38871,53821,53848</link.rule.ids></links><search><creatorcontrib>Purba, H H S</creatorcontrib><creatorcontrib>Paramita, R</creatorcontrib><creatorcontrib>Prijanti, A R</creatorcontrib><creatorcontrib>Iswanti, F C</creatorcontrib><title>Supplementation of Spirulina platensis ethanol extract: influence on mRNA expression and prediction of molecular interactions with IL-10</title><title>IOP conference series. Earth and environmental science</title><addtitle>IOP Conf. Ser.: Earth Environ. Sci</addtitle><description>Alleviation of inflammation requires an optimal balance between pro and anti-inflammatory cytokines, in which IL-10 plays a critical role as a major anti-inflammatory cytokine. Studies about the ability of the active component of
Spirulina platensis
to promote IL-10 expression still vary. This study aims to analyze the effect of
S. platensis
on IL-10 mRNA expression in healthy rats of emerging adults and young adults. This study used six groups of male Wistar rats aged 12, 18, and 24 weeks treated with 200 mg/kg BW of
S. platensis
extract and a control group. Molecular interaction was predicted between three bioactive compounds of
S. platensis
(α-glucan, β-carotene, phycocyanobilin) and tacrolimus (control ligand) with IL-10 protein. The relative expression ratio of IL-10 mRNA increased in the treatment rats at 12 weeks (1.77) and 24 weeks (2.05). In rats aged 18 weeks, there was no increase in the expression ratio of IL-10 mRNA in treated rats compared to controls (0.91). Tacrolimus, the control ligand, has the best affinity as an IL-10 inhibitor (-6.68 kcal/mol), followed by β-carotene (-5.83 kcal/mol). The ethanolic extract of
S. platensis
can potentially increase the expression of IL-10 mRNA in the rat spleen at 12 and 24 weeks.</description><subject>Adults</subject><subject>Bioactive compounds</subject><subject>Carotene</subject><subject>Cyanobacteria</subject><subject>Cytokines</subject><subject>Ethanol</subject><subject>Gene expression</subject><subject>Glucan</subject><subject>IL-10</subject><subject>Inflammation</subject><subject>Interleukin 10</subject><subject>Ligands</subject><subject>molecular interaction</subject><subject>Molecular interactions</subject><subject>mRNA expression</subject><subject>Phycocyanobilin</subject><subject>rat spleen</subject><subject>Spirulina platensis</subject><subject>Tacrolimus</subject><subject>Young adults</subject><subject>β-Carotene</subject><issn>1755-1307</issn><issn>1755-1315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>O3W</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkN1KAzEQhRdRUKvPYMArL9ZOsj_JeidStVAUbO9Dmk0wss3GJIv6Bj62WeoPguDVzHDO-QZOlp1gOMfA2BTTqspxgaspJhRP8RQwAYZ3soNvZfd7B7qfHYbwBFDTsmgOsvfl4FynNspGEU1vUa_R0hk_dMYK5DoRlQ0mIBUfhe07pF6jFzJeIGN1NygrFUqhzcPdZZKcVyGMEGFblI7WyC_mpu-UHDrhUzCqEZGEgF5MfETzRY7hKNvTogvq-HNOstX1bHV1my_ub-ZXl4tcElrgvCakBC3W0GpgjWaiFA2TdUmgaNe0ASorVeJ1RYkACSVmupFlzdYUSqJYXUyy0y3W-f55UCHyp37wNn3kJKVpU5OiSC66dUnfh-CV5s6bjfBvHAMfW-djn3zslo-tc8y3rafk2TZpeveDns2Wv33ctTp5iz-8_334AIvUko0</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Purba, H H S</creator><creator>Paramita, R</creator><creator>Prijanti, A R</creator><creator>Iswanti, F C</creator><general>IOP Publishing</general><scope>O3W</scope><scope>TSCCA</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>PATMY</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PYCSY</scope></search><sort><creationdate>20231201</creationdate><title>Supplementation of Spirulina platensis ethanol extract: influence on mRNA expression and prediction of molecular interactions with IL-10</title><author>Purba, H H S ; Paramita, R ; Prijanti, A R ; Iswanti, F C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2731-62240fab0df089f8a4a98c64203db7907c5e41b572a0c0418f9c468b7042e863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adults</topic><topic>Bioactive compounds</topic><topic>Carotene</topic><topic>Cyanobacteria</topic><topic>Cytokines</topic><topic>Ethanol</topic><topic>Gene expression</topic><topic>Glucan</topic><topic>IL-10</topic><topic>Inflammation</topic><topic>Interleukin 10</topic><topic>Ligands</topic><topic>molecular interaction</topic><topic>Molecular interactions</topic><topic>mRNA expression</topic><topic>Phycocyanobilin</topic><topic>rat spleen</topic><topic>Spirulina platensis</topic><topic>Tacrolimus</topic><topic>Young adults</topic><topic>β-Carotene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Purba, H H S</creatorcontrib><creatorcontrib>Paramita, R</creatorcontrib><creatorcontrib>Prijanti, A R</creatorcontrib><creatorcontrib>Iswanti, F C</creatorcontrib><collection>IOP Publishing Free Content</collection><collection>IOPscience (Open Access)</collection><collection>CrossRef</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Environmental Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environmental Science Collection</collection><jtitle>IOP conference series. Earth and environmental science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Purba, H H S</au><au>Paramita, R</au><au>Prijanti, A R</au><au>Iswanti, F C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Supplementation of Spirulina platensis ethanol extract: influence on mRNA expression and prediction of molecular interactions with IL-10</atitle><jtitle>IOP conference series. Earth and environmental science</jtitle><addtitle>IOP Conf. Ser.: Earth Environ. Sci</addtitle><date>2023-12-01</date><risdate>2023</risdate><volume>1271</volume><issue>1</issue><spage>12081</spage><pages>12081-</pages><issn>1755-1307</issn><eissn>1755-1315</eissn><abstract>Alleviation of inflammation requires an optimal balance between pro and anti-inflammatory cytokines, in which IL-10 plays a critical role as a major anti-inflammatory cytokine. Studies about the ability of the active component of
Spirulina platensis
to promote IL-10 expression still vary. This study aims to analyze the effect of
S. platensis
on IL-10 mRNA expression in healthy rats of emerging adults and young adults. This study used six groups of male Wistar rats aged 12, 18, and 24 weeks treated with 200 mg/kg BW of
S. platensis
extract and a control group. Molecular interaction was predicted between three bioactive compounds of
S. platensis
(α-glucan, β-carotene, phycocyanobilin) and tacrolimus (control ligand) with IL-10 protein. The relative expression ratio of IL-10 mRNA increased in the treatment rats at 12 weeks (1.77) and 24 weeks (2.05). In rats aged 18 weeks, there was no increase in the expression ratio of IL-10 mRNA in treated rats compared to controls (0.91). Tacrolimus, the control ligand, has the best affinity as an IL-10 inhibitor (-6.68 kcal/mol), followed by β-carotene (-5.83 kcal/mol). The ethanolic extract of
S. platensis
can potentially increase the expression of IL-10 mRNA in the rat spleen at 12 and 24 weeks.</abstract><cop>Bristol</cop><pub>IOP Publishing</pub><doi>10.1088/1755-1315/1271/1/012081</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adults Bioactive compounds Carotene Cyanobacteria Cytokines Ethanol Gene expression Glucan IL-10 Inflammation Interleukin 10 Ligands molecular interaction Molecular interactions mRNA expression Phycocyanobilin rat spleen Spirulina platensis Tacrolimus Young adults β-Carotene |
| title | Supplementation of Spirulina platensis ethanol extract: influence on mRNA expression and prediction of molecular interactions with IL-10 |
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