Investigation of controlled drug release of ibuprofen with prepared and characterized innovative bigel materials
New systems called bigels have been discovered recently, alongside other consolidations of hydrogels and organogels. The purpose of this research is to develop bigels using span 40, alginate, centaury oil, black cumin oil and sorbitan monopalmitate for controlled ibuprofen release. Characterization...
Gespeichert in:
Veröffentlicht in: | Materialwissenschaft und Werkstofftechnik 2023-12, Vol.54 (12), p.1707-1716 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 1716 |
---|---|
container_issue | 12 |
container_start_page | 1707 |
container_title | Materialwissenschaft und Werkstofftechnik |
container_volume | 54 |
creator | Kizilhan, E. Özcan, Y. Erden Gönenmiş, D. Mutlu, D. Gök, C. Arslan, Ş. |
description | New systems called bigels have been discovered recently, alongside other consolidations of hydrogels and organogels. The purpose of this research is to develop bigels using span 40, alginate, centaury oil, black cumin oil and sorbitan monopalmitate for controlled ibuprofen release. Characterization of prepared materials was performed using various analysis by fourier transform infrared spectroscopy and differential scanning calorimetry. The pH 7.2 level was used for the swelling test of bigels. Cytocompatibility of bigels was determined by using human immortalized human keratinocyte cells. Bigels have been tested for their effectiveness as controlled medication delivery formulations by
in vitro
studies. The prepared bigels did not show any toxic effects on human cells. This indicates that the prepared materials were biocompatible. For controlled drug release kinetics, zeroth‐order, first‐order, Higuchi, and Korsmeyer‐Peppas kinetic models were used. According to results, the kinetic modeling of bigels by Korsmeyer‐Peppas is also highly compatible. Consequently, controlled drug release was successfully carried out by the novel bigel materials formed by adding an active ingredient. Our results clearly indicate that bigels have been an alternative potential material for controlled drug delivery systems by the properties of biocompatibility, slower release of the drug and the diffusion release mechanism. |
doi_str_mv | 10.1002/mawe.202300045 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2906766451</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2906766451</sourcerecordid><originalsourceid>FETCH-LOGICAL-c137t-e88df86327cc8f1dbb5174b394c3b7e1bd3f71a330ec2e92b979e66dedd202cd3</originalsourceid><addsrcrecordid>eNo9kEtPwzAQhC0EEqVw5WyJc4ofSRwfUcWjUiUucI782KSuUjs4SSv49Tgq4rTSzmh29kPonpIVJYQ9HtQJVowwTgjJiwu0oAWjWU4KdokWRHKeFZSLa3QzDPtkkVIUC9Rv_BGG0bVqdMHj0GAT_BhD14HFNk4tjtCBGmCWnJ76GBrw-OTGHe4j9Comn_IWm52KyowQ3U_aOO_DMUUeAWvXQocPapZUN9yiqyYNuPubS_T58vyxfsu276-b9dM2M6nkmEFV2aYqORPGVA21WhdU5JrL3HAtgGrLG0EV5wQMA8m0FBLK0oK1CYGxfIkezrmp8deUXqz3YYo-nayZJKUoyzzhWKLV2WViGIYITd1Hd1Dxu6aknqnWM9X6nyr_BVK9bgY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2906766451</pqid></control><display><type>article</type><title>Investigation of controlled drug release of ibuprofen with prepared and characterized innovative bigel materials</title><source>Wiley Journals</source><creator>Kizilhan, E. ; Özcan, Y. ; Erden Gönenmiş, D. ; Mutlu, D. ; Gök, C. ; Arslan, Ş.</creator><creatorcontrib>Kizilhan, E. ; Özcan, Y. ; Erden Gönenmiş, D. ; Mutlu, D. ; Gök, C. ; Arslan, Ş.</creatorcontrib><description>New systems called bigels have been discovered recently, alongside other consolidations of hydrogels and organogels. The purpose of this research is to develop bigels using span 40, alginate, centaury oil, black cumin oil and sorbitan monopalmitate for controlled ibuprofen release. Characterization of prepared materials was performed using various analysis by fourier transform infrared spectroscopy and differential scanning calorimetry. The pH 7.2 level was used for the swelling test of bigels. Cytocompatibility of bigels was determined by using human immortalized human keratinocyte cells. Bigels have been tested for their effectiveness as controlled medication delivery formulations by
in vitro
studies. The prepared bigels did not show any toxic effects on human cells. This indicates that the prepared materials were biocompatible. For controlled drug release kinetics, zeroth‐order, first‐order, Higuchi, and Korsmeyer‐Peppas kinetic models were used. According to results, the kinetic modeling of bigels by Korsmeyer‐Peppas is also highly compatible. Consequently, controlled drug release was successfully carried out by the novel bigel materials formed by adding an active ingredient. Our results clearly indicate that bigels have been an alternative potential material for controlled drug delivery systems by the properties of biocompatibility, slower release of the drug and the diffusion release mechanism.</description><identifier>ISSN: 0933-5137</identifier><identifier>EISSN: 1521-4052</identifier><identifier>DOI: 10.1002/mawe.202300045</identifier><language>eng</language><publisher>Weinheim: Wiley Subscription Services, Inc</publisher><subject>Alginates ; Biocompatibility ; Diffusion rate ; Drug delivery systems ; Fourier transforms ; Ibuprofen ; Infrared analysis ; Nonsteroidal anti-inflammatory drugs</subject><ispartof>Materialwissenschaft und Werkstofftechnik, 2023-12, Vol.54 (12), p.1707-1716</ispartof><rights>2023 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c137t-e88df86327cc8f1dbb5174b394c3b7e1bd3f71a330ec2e92b979e66dedd202cd3</cites><orcidid>0000-0003-4355-5383</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Kizilhan, E.</creatorcontrib><creatorcontrib>Özcan, Y.</creatorcontrib><creatorcontrib>Erden Gönenmiş, D.</creatorcontrib><creatorcontrib>Mutlu, D.</creatorcontrib><creatorcontrib>Gök, C.</creatorcontrib><creatorcontrib>Arslan, Ş.</creatorcontrib><title>Investigation of controlled drug release of ibuprofen with prepared and characterized innovative bigel materials</title><title>Materialwissenschaft und Werkstofftechnik</title><description>New systems called bigels have been discovered recently, alongside other consolidations of hydrogels and organogels. The purpose of this research is to develop bigels using span 40, alginate, centaury oil, black cumin oil and sorbitan monopalmitate for controlled ibuprofen release. Characterization of prepared materials was performed using various analysis by fourier transform infrared spectroscopy and differential scanning calorimetry. The pH 7.2 level was used for the swelling test of bigels. Cytocompatibility of bigels was determined by using human immortalized human keratinocyte cells. Bigels have been tested for their effectiveness as controlled medication delivery formulations by
in vitro
studies. The prepared bigels did not show any toxic effects on human cells. This indicates that the prepared materials were biocompatible. For controlled drug release kinetics, zeroth‐order, first‐order, Higuchi, and Korsmeyer‐Peppas kinetic models were used. According to results, the kinetic modeling of bigels by Korsmeyer‐Peppas is also highly compatible. Consequently, controlled drug release was successfully carried out by the novel bigel materials formed by adding an active ingredient. Our results clearly indicate that bigels have been an alternative potential material for controlled drug delivery systems by the properties of biocompatibility, slower release of the drug and the diffusion release mechanism.</description><subject>Alginates</subject><subject>Biocompatibility</subject><subject>Diffusion rate</subject><subject>Drug delivery systems</subject><subject>Fourier transforms</subject><subject>Ibuprofen</subject><subject>Infrared analysis</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><issn>0933-5137</issn><issn>1521-4052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNo9kEtPwzAQhC0EEqVw5WyJc4ofSRwfUcWjUiUucI782KSuUjs4SSv49Tgq4rTSzmh29kPonpIVJYQ9HtQJVowwTgjJiwu0oAWjWU4KdokWRHKeFZSLa3QzDPtkkVIUC9Rv_BGG0bVqdMHj0GAT_BhD14HFNk4tjtCBGmCWnJ76GBrw-OTGHe4j9Comn_IWm52KyowQ3U_aOO_DMUUeAWvXQocPapZUN9yiqyYNuPubS_T58vyxfsu276-b9dM2M6nkmEFV2aYqORPGVA21WhdU5JrL3HAtgGrLG0EV5wQMA8m0FBLK0oK1CYGxfIkezrmp8deUXqz3YYo-nayZJKUoyzzhWKLV2WViGIYITd1Hd1Dxu6aknqnWM9X6nyr_BVK9bgY</recordid><startdate>202312</startdate><enddate>202312</enddate><creator>Kizilhan, E.</creator><creator>Özcan, Y.</creator><creator>Erden Gönenmiş, D.</creator><creator>Mutlu, D.</creator><creator>Gök, C.</creator><creator>Arslan, Ş.</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7TB</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>KR7</scope><orcidid>https://orcid.org/0000-0003-4355-5383</orcidid></search><sort><creationdate>202312</creationdate><title>Investigation of controlled drug release of ibuprofen with prepared and characterized innovative bigel materials</title><author>Kizilhan, E. ; Özcan, Y. ; Erden Gönenmiş, D. ; Mutlu, D. ; Gök, C. ; Arslan, Ş.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c137t-e88df86327cc8f1dbb5174b394c3b7e1bd3f71a330ec2e92b979e66dedd202cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alginates</topic><topic>Biocompatibility</topic><topic>Diffusion rate</topic><topic>Drug delivery systems</topic><topic>Fourier transforms</topic><topic>Ibuprofen</topic><topic>Infrared analysis</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kizilhan, E.</creatorcontrib><creatorcontrib>Özcan, Y.</creatorcontrib><creatorcontrib>Erden Gönenmiş, D.</creatorcontrib><creatorcontrib>Mutlu, D.</creatorcontrib><creatorcontrib>Gök, C.</creatorcontrib><creatorcontrib>Arslan, Ş.</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Civil Engineering Abstracts</collection><jtitle>Materialwissenschaft und Werkstofftechnik</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kizilhan, E.</au><au>Özcan, Y.</au><au>Erden Gönenmiş, D.</au><au>Mutlu, D.</au><au>Gök, C.</au><au>Arslan, Ş.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of controlled drug release of ibuprofen with prepared and characterized innovative bigel materials</atitle><jtitle>Materialwissenschaft und Werkstofftechnik</jtitle><date>2023-12</date><risdate>2023</risdate><volume>54</volume><issue>12</issue><spage>1707</spage><epage>1716</epage><pages>1707-1716</pages><issn>0933-5137</issn><eissn>1521-4052</eissn><abstract>New systems called bigels have been discovered recently, alongside other consolidations of hydrogels and organogels. The purpose of this research is to develop bigels using span 40, alginate, centaury oil, black cumin oil and sorbitan monopalmitate for controlled ibuprofen release. Characterization of prepared materials was performed using various analysis by fourier transform infrared spectroscopy and differential scanning calorimetry. The pH 7.2 level was used for the swelling test of bigels. Cytocompatibility of bigels was determined by using human immortalized human keratinocyte cells. Bigels have been tested for their effectiveness as controlled medication delivery formulations by
in vitro
studies. The prepared bigels did not show any toxic effects on human cells. This indicates that the prepared materials were biocompatible. For controlled drug release kinetics, zeroth‐order, first‐order, Higuchi, and Korsmeyer‐Peppas kinetic models were used. According to results, the kinetic modeling of bigels by Korsmeyer‐Peppas is also highly compatible. Consequently, controlled drug release was successfully carried out by the novel bigel materials formed by adding an active ingredient. Our results clearly indicate that bigels have been an alternative potential material for controlled drug delivery systems by the properties of biocompatibility, slower release of the drug and the diffusion release mechanism.</abstract><cop>Weinheim</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/mawe.202300045</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-4355-5383</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0933-5137 |
ispartof | Materialwissenschaft und Werkstofftechnik, 2023-12, Vol.54 (12), p.1707-1716 |
issn | 0933-5137 1521-4052 |
language | eng |
recordid | cdi_proquest_journals_2906766451 |
source | Wiley Journals |
subjects | Alginates Biocompatibility Diffusion rate Drug delivery systems Fourier transforms Ibuprofen Infrared analysis Nonsteroidal anti-inflammatory drugs |
title | Investigation of controlled drug release of ibuprofen with prepared and characterized innovative bigel materials |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T00%3A36%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Investigation%20of%20controlled%20drug%20release%20of%20ibuprofen%20with%20prepared%20and%20characterized%20innovative%20bigel%20materials&rft.jtitle=Materialwissenschaft%20und%20Werkstofftechnik&rft.au=Kizilhan,%20E.&rft.date=2023-12&rft.volume=54&rft.issue=12&rft.spage=1707&rft.epage=1716&rft.pages=1707-1716&rft.issn=0933-5137&rft.eissn=1521-4052&rft_id=info:doi/10.1002/mawe.202300045&rft_dat=%3Cproquest_cross%3E2906766451%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2906766451&rft_id=info:pmid/&rfr_iscdi=true |