Composition of Lipophilic Components of Rhododendron adamsii Rehd. Ether Extract and Activity against SARS-CoV-2 Main Protease
The composition of the lipophilic components of Rhododendron adamsii Rehd. was studied. Acidic and neutral components were identified by gas chromatography-mass spectrometry. Methyl tert-butyl ether (MTBE), which offers all the advantages of diethyl ether but is free of its disadvantages, was used a...
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| Veröffentlicht in: | Russian journal of bioorganic chemistry 2023-12, Vol.49 (7), p.1730-1739 |
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| container_title | Russian journal of bioorganic chemistry |
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| creator | Kukina, T. P. Elshin, I. A. Sal’nikova, O. I. Kolosov, P. V. Sandag, Ts Karakai, D. A. Bondareva, M. A. Nefedov, A. A. Chirkova, V. Yu Sharlaeva, E. A. Belen’kaya, S. V. Shcherbakov, D. N. |
| description | The composition of the lipophilic components of
Rhododendron adamsii
Rehd. was studied. Acidic and neutral components were identified by gas chromatography-mass spectrometry. Methyl tert-butyl ether (MTBE), which offers all the advantages of diethyl ether but is free of its disadvantages, was used as the extraction solvent for the raw materials. It does not form peroxides or create increased gas pressure due to its higher boiling point. As a result, comparison with databases allowed identification of triterpenic, phenolcarboxylic, and aliphatic acids with chain lengths of 8 to 30 carbon atoms, including saturated, unsaturated, and dibasic acids. More than 150 triterpenic and aliphatic components of the unsaponifiable residue and acidic fractions were identified. Unsaponifiable residues of lipophilic extracts have previously received almost no research attention. Only components of the essential oils of
Rh. adamsii
and of other species of the genus
Rhododendron
have been studied in detail. For bioactivity testing, samples of the whole extract and of its fractions were prepared. Some of the studied samples showed inhibitory activity against the main protease of SARS-CoV-2. |
| doi_str_mv | 10.1134/S1068162023070828 |
| format | Article |
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Rhododendron adamsii
Rehd. was studied. Acidic and neutral components were identified by gas chromatography-mass spectrometry. Methyl tert-butyl ether (MTBE), which offers all the advantages of diethyl ether but is free of its disadvantages, was used as the extraction solvent for the raw materials. It does not form peroxides or create increased gas pressure due to its higher boiling point. As a result, comparison with databases allowed identification of triterpenic, phenolcarboxylic, and aliphatic acids with chain lengths of 8 to 30 carbon atoms, including saturated, unsaturated, and dibasic acids. More than 150 triterpenic and aliphatic components of the unsaponifiable residue and acidic fractions were identified. Unsaponifiable residues of lipophilic extracts have previously received almost no research attention. Only components of the essential oils of
Rh. adamsii
and of other species of the genus
Rhododendron
have been studied in detail. For bioactivity testing, samples of the whole extract and of its fractions were prepared. Some of the studied samples showed inhibitory activity against the main protease of SARS-CoV-2.</description><identifier>ISSN: 1068-1620</identifier><identifier>EISSN: 1608-330X</identifier><identifier>DOI: 10.1134/S1068162023070828</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Aliphatic compounds ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Bioorganic Chemistry ; Boiling points ; Composition ; Diethyl ether ; Essential oils ; Gas chromatography ; Gas pressure ; Life Sciences ; Lipophilicity ; Mass spectrometry ; Organic Chemistry ; Peroxides ; Protease ; Raw materials ; Residues ; Severe acute respiratory syndrome coronavirus 2</subject><ispartof>Russian journal of bioorganic chemistry, 2023-12, Vol.49 (7), p.1730-1739</ispartof><rights>Pleiades Publishing, Ltd. 2023</rights><rights>Pleiades Publishing, Ltd. 2023.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c268t-dcd5fe986f3e8f57e1ac08700d68e0cdd7c43da70519747de8d4c027220505b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1068162023070828$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1068162023070828$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Kukina, T. P.</creatorcontrib><creatorcontrib>Elshin, I. A.</creatorcontrib><creatorcontrib>Sal’nikova, O. I.</creatorcontrib><creatorcontrib>Kolosov, P. V.</creatorcontrib><creatorcontrib>Sandag, Ts</creatorcontrib><creatorcontrib>Karakai, D. A.</creatorcontrib><creatorcontrib>Bondareva, M. A.</creatorcontrib><creatorcontrib>Nefedov, A. A.</creatorcontrib><creatorcontrib>Chirkova, V. Yu</creatorcontrib><creatorcontrib>Sharlaeva, E. A.</creatorcontrib><creatorcontrib>Belen’kaya, S. V.</creatorcontrib><creatorcontrib>Shcherbakov, D. N.</creatorcontrib><title>Composition of Lipophilic Components of Rhododendron adamsii Rehd. Ether Extract and Activity against SARS-CoV-2 Main Protease</title><title>Russian journal of bioorganic chemistry</title><addtitle>Russ J Bioorg Chem</addtitle><description>The composition of the lipophilic components of
Rhododendron adamsii
Rehd. was studied. Acidic and neutral components were identified by gas chromatography-mass spectrometry. Methyl tert-butyl ether (MTBE), which offers all the advantages of diethyl ether but is free of its disadvantages, was used as the extraction solvent for the raw materials. It does not form peroxides or create increased gas pressure due to its higher boiling point. As a result, comparison with databases allowed identification of triterpenic, phenolcarboxylic, and aliphatic acids with chain lengths of 8 to 30 carbon atoms, including saturated, unsaturated, and dibasic acids. More than 150 triterpenic and aliphatic components of the unsaponifiable residue and acidic fractions were identified. Unsaponifiable residues of lipophilic extracts have previously received almost no research attention. Only components of the essential oils of
Rh. adamsii
and of other species of the genus
Rhododendron
have been studied in detail. For bioactivity testing, samples of the whole extract and of its fractions were prepared. Some of the studied samples showed inhibitory activity against the main protease of SARS-CoV-2.</description><subject>Aliphatic compounds</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>Boiling points</subject><subject>Composition</subject><subject>Diethyl ether</subject><subject>Essential oils</subject><subject>Gas chromatography</subject><subject>Gas pressure</subject><subject>Life Sciences</subject><subject>Lipophilicity</subject><subject>Mass spectrometry</subject><subject>Organic Chemistry</subject><subject>Peroxides</subject><subject>Protease</subject><subject>Raw materials</subject><subject>Residues</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><issn>1068-1620</issn><issn>1608-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kEtLAzEUhQdRsFZ_gLuA66k3mUcyyzLUB1SUVsXdEJNMJ6VNxiQVu_G3m1rBhbi6l_udcy6cJDnHMMI4yy_nGEqGSwIkAwqMsINkgEtgaZbBy2HcI053_Dg58X4JgAEKNkg-a7vurddBW4Nsi6a6t32nV1qgb2KUCX4HZp2VViojXRRyyddeazRTnRyhSeiUQ5OP4LgIiBuJxiLodx22iC-4Nj6g-Xg2T2v7nBJ0Fy_owdmguFenyVHLV16d_cxh8nQ1eaxv0un99W09nqaClCykUsiiVRUr20yxtqAKcwGMAsiSKRBSUpFnklMocEVzKhWTuQBCCYECitcqGyYX-9ze2beN8qFZ2o0z8WVDqlgEiWE4qvBeJZz13qm26Z1ec7dtMDS7mps_NUcP2Xt81JqFcr_J_5u-ADHJfuY</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Kukina, T. P.</creator><creator>Elshin, I. A.</creator><creator>Sal’nikova, O. I.</creator><creator>Kolosov, P. V.</creator><creator>Sandag, Ts</creator><creator>Karakai, D. A.</creator><creator>Bondareva, M. A.</creator><creator>Nefedov, A. A.</creator><creator>Chirkova, V. Yu</creator><creator>Sharlaeva, E. A.</creator><creator>Belen’kaya, S. V.</creator><creator>Shcherbakov, D. N.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20231201</creationdate><title>Composition of Lipophilic Components of Rhododendron adamsii Rehd. Ether Extract and Activity against SARS-CoV-2 Main Protease</title><author>Kukina, T. P. ; Elshin, I. A. ; Sal’nikova, O. I. ; Kolosov, P. V. ; Sandag, Ts ; Karakai, D. A. ; Bondareva, M. A. ; Nefedov, A. A. ; Chirkova, V. Yu ; Sharlaeva, E. A. ; Belen’kaya, S. V. ; Shcherbakov, D. 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Rhododendron adamsii
Rehd. was studied. Acidic and neutral components were identified by gas chromatography-mass spectrometry. Methyl tert-butyl ether (MTBE), which offers all the advantages of diethyl ether but is free of its disadvantages, was used as the extraction solvent for the raw materials. It does not form peroxides or create increased gas pressure due to its higher boiling point. As a result, comparison with databases allowed identification of triterpenic, phenolcarboxylic, and aliphatic acids with chain lengths of 8 to 30 carbon atoms, including saturated, unsaturated, and dibasic acids. More than 150 triterpenic and aliphatic components of the unsaponifiable residue and acidic fractions were identified. Unsaponifiable residues of lipophilic extracts have previously received almost no research attention. Only components of the essential oils of
Rh. adamsii
and of other species of the genus
Rhododendron
have been studied in detail. For bioactivity testing, samples of the whole extract and of its fractions were prepared. Some of the studied samples showed inhibitory activity against the main protease of SARS-CoV-2.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1068162023070828</doi><tpages>10</tpages></addata></record> |
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| subjects | Aliphatic compounds Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Boiling points Composition Diethyl ether Essential oils Gas chromatography Gas pressure Life Sciences Lipophilicity Mass spectrometry Organic Chemistry Peroxides Protease Raw materials Residues Severe acute respiratory syndrome coronavirus 2 |
| title | Composition of Lipophilic Components of Rhododendron adamsii Rehd. Ether Extract and Activity against SARS-CoV-2 Main Protease |
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