Influence of Factors of 21-Day Head-Down Bed Rest on the Blood Level of Myocardial Extensibility Biomarker ST2
— Head-down bed rest (HDBR) is one of the best known models of the effects of weightlessness. The responses of the cardiovascular system to thoracocranial blood redistribution continue to be studied in relation to changes in the volumes of the heart chambers and the structure of the heart muscle. Th...
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| Veröffentlicht in: | Human physiology 2023-12, Vol.49 (6), p.605-608 |
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| creator | Pastushkova, L. Kh Goncharova, A. G. Kashirina, D. N. Goncharov, I. N. Larina, I. M. |
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Head-down bed rest (HDBR) is one of the best known models of the effects of weightlessness. The responses of the cardiovascular system to thoracocranial blood redistribution continue to be studied in relation to changes in the volumes of the heart chambers and the structure of the heart muscle. The assessment of myocardial stretch, individual response of the heart muscle to HDBR, and stratification of the risk of developing heart failure according to the dynamics of a cardiomarker not dependent on the influence of such factors as gender, age, body weight, glomerular filtration rate, anemia, and hypovolemia is relevant. The aim of the study was to investigate the influence of factors of 21-day HDBR on the level of the ST2 myocardial stretch biomarker. The effect of 21-day HDBR on the level of the ST2 cardiomyocyte stretch marker was studied for the first time. The level of ST2 significantly decreased by the end of HDBR. The data obtained are of practical importance in relation to the problems of medical selection of cosmonauts and test volunteers. Background levels, variability of indicators during HDBR, and the recovery period indicate the absence of risks for the development of heart failure and cardiofibrosis in this sample of subjects in this study. |
| doi_str_mv | 10.1134/S0362119723600261 |
| format | Article |
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Head-down bed rest (HDBR) is one of the best known models of the effects of weightlessness. The responses of the cardiovascular system to thoracocranial blood redistribution continue to be studied in relation to changes in the volumes of the heart chambers and the structure of the heart muscle. The assessment of myocardial stretch, individual response of the heart muscle to HDBR, and stratification of the risk of developing heart failure according to the dynamics of a cardiomarker not dependent on the influence of such factors as gender, age, body weight, glomerular filtration rate, anemia, and hypovolemia is relevant. The aim of the study was to investigate the influence of factors of 21-day HDBR on the level of the ST2 myocardial stretch biomarker. The effect of 21-day HDBR on the level of the ST2 cardiomyocyte stretch marker was studied for the first time. The level of ST2 significantly decreased by the end of HDBR. The data obtained are of practical importance in relation to the problems of medical selection of cosmonauts and test volunteers. Background levels, variability of indicators during HDBR, and the recovery period indicate the absence of risks for the development of heart failure and cardiofibrosis in this sample of subjects in this study.</description><identifier>ISSN: 0362-1197</identifier><identifier>EISSN: 1608-3164</identifier><identifier>DOI: 10.1134/S0362119723600261</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Background levels ; Biomarkers ; Biomedical and Life Sciences ; Biomedicine ; Blood levels ; Body weight ; Cardiac muscle ; Cardiomyocytes ; Cardiovascular system ; Congestive heart failure ; Glomerular filtration rate ; Heart failure ; Human Physiology ; Immobilization ; Life Sciences ; Weightlessness</subject><ispartof>Human physiology, 2023-12, Vol.49 (6), p.605-608</ispartof><rights>Pleiades Publishing, Inc. 2023. ISSN 0362-1197, Human Physiology, 2023, Vol. 49, No. 6, pp. 605–608. © Pleiades Publishing, Inc., 2023. Russian Text © The Author(s), 2023, published in Fiziologiya Cheloveka, 2023, Vol. 49, No. 6, pp. 36–40.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1831-4cd62043e3817b86ded342afb00208c24902b1f44aa45b6f6359b070758621d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S0362119723600261$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S0362119723600261$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids></links><search><creatorcontrib>Pastushkova, L. Kh</creatorcontrib><creatorcontrib>Goncharova, A. G.</creatorcontrib><creatorcontrib>Kashirina, D. N.</creatorcontrib><creatorcontrib>Goncharov, I. N.</creatorcontrib><creatorcontrib>Larina, I. M.</creatorcontrib><title>Influence of Factors of 21-Day Head-Down Bed Rest on the Blood Level of Myocardial Extensibility Biomarker ST2</title><title>Human physiology</title><addtitle>Hum Physiol</addtitle><description>—
Head-down bed rest (HDBR) is one of the best known models of the effects of weightlessness. The responses of the cardiovascular system to thoracocranial blood redistribution continue to be studied in relation to changes in the volumes of the heart chambers and the structure of the heart muscle. The assessment of myocardial stretch, individual response of the heart muscle to HDBR, and stratification of the risk of developing heart failure according to the dynamics of a cardiomarker not dependent on the influence of such factors as gender, age, body weight, glomerular filtration rate, anemia, and hypovolemia is relevant. The aim of the study was to investigate the influence of factors of 21-day HDBR on the level of the ST2 myocardial stretch biomarker. The effect of 21-day HDBR on the level of the ST2 cardiomyocyte stretch marker was studied for the first time. The level of ST2 significantly decreased by the end of HDBR. The data obtained are of practical importance in relation to the problems of medical selection of cosmonauts and test volunteers. Background levels, variability of indicators during HDBR, and the recovery period indicate the absence of risks for the development of heart failure and cardiofibrosis in this sample of subjects in this study.</description><subject>Background levels</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood levels</subject><subject>Body weight</subject><subject>Cardiac muscle</subject><subject>Cardiomyocytes</subject><subject>Cardiovascular system</subject><subject>Congestive heart failure</subject><subject>Glomerular filtration rate</subject><subject>Heart failure</subject><subject>Human Physiology</subject><subject>Immobilization</subject><subject>Life Sciences</subject><subject>Weightlessness</subject><issn>0362-1197</issn><issn>1608-3164</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1UMtOwzAQtBBIlMIHcLPEOeC1HSc50hetVIREyzlyYgdSgl3sBMjf46hIHBCnXWkeOzsIXQK5BmD8ZkOYoABZQpkghAo4QiMQJI0YCH6MRgMcDfgpOvN-RwhJIM1GyKxM1XTalBrbCi9k2Vrnh5VCNJM9Xmqpopn9NHiiFX7UvsXW4PZF40ljrcJr_aGbgX_f21I6VcsGz79abXxd1E3d9nhS2zfpXrXDmy09RyeVbLy--Jlj9LSYb6fLaP1wt5rerqMSUgYRL5WghDPNUkiKVCitGKeyKsJrJC0pzwgtoOJcSh4XohIszgqSkCROQwsqZmN0dfDdO_vehdT5znbOhJM5zUjMuOBMBBYcWKWz3jtd5XtXh7B9DiQfas3_1Bo09KDxgWuetft1_l_0Dd2PdjQ</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Pastushkova, L. Kh</creator><creator>Goncharova, A. G.</creator><creator>Kashirina, D. N.</creator><creator>Goncharov, I. N.</creator><creator>Larina, I. M.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20231201</creationdate><title>Influence of Factors of 21-Day Head-Down Bed Rest on the Blood Level of Myocardial Extensibility Biomarker ST2</title><author>Pastushkova, L. Kh ; Goncharova, A. G. ; Kashirina, D. N. ; Goncharov, I. N. ; Larina, I. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1831-4cd62043e3817b86ded342afb00208c24902b1f44aa45b6f6359b070758621d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Background levels</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood levels</topic><topic>Body weight</topic><topic>Cardiac muscle</topic><topic>Cardiomyocytes</topic><topic>Cardiovascular system</topic><topic>Congestive heart failure</topic><topic>Glomerular filtration rate</topic><topic>Heart failure</topic><topic>Human Physiology</topic><topic>Immobilization</topic><topic>Life Sciences</topic><topic>Weightlessness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pastushkova, L. Kh</creatorcontrib><creatorcontrib>Goncharova, A. G.</creatorcontrib><creatorcontrib>Kashirina, D. N.</creatorcontrib><creatorcontrib>Goncharov, I. N.</creatorcontrib><creatorcontrib>Larina, I. M.</creatorcontrib><collection>CrossRef</collection><jtitle>Human physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pastushkova, L. Kh</au><au>Goncharova, A. G.</au><au>Kashirina, D. N.</au><au>Goncharov, I. N.</au><au>Larina, I. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Factors of 21-Day Head-Down Bed Rest on the Blood Level of Myocardial Extensibility Biomarker ST2</atitle><jtitle>Human physiology</jtitle><stitle>Hum Physiol</stitle><date>2023-12-01</date><risdate>2023</risdate><volume>49</volume><issue>6</issue><spage>605</spage><epage>608</epage><pages>605-608</pages><issn>0362-1197</issn><eissn>1608-3164</eissn><abstract>—
Head-down bed rest (HDBR) is one of the best known models of the effects of weightlessness. The responses of the cardiovascular system to thoracocranial blood redistribution continue to be studied in relation to changes in the volumes of the heart chambers and the structure of the heart muscle. The assessment of myocardial stretch, individual response of the heart muscle to HDBR, and stratification of the risk of developing heart failure according to the dynamics of a cardiomarker not dependent on the influence of such factors as gender, age, body weight, glomerular filtration rate, anemia, and hypovolemia is relevant. The aim of the study was to investigate the influence of factors of 21-day HDBR on the level of the ST2 myocardial stretch biomarker. The effect of 21-day HDBR on the level of the ST2 cardiomyocyte stretch marker was studied for the first time. The level of ST2 significantly decreased by the end of HDBR. The data obtained are of practical importance in relation to the problems of medical selection of cosmonauts and test volunteers. Background levels, variability of indicators during HDBR, and the recovery period indicate the absence of risks for the development of heart failure and cardiofibrosis in this sample of subjects in this study.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S0362119723600261</doi><tpages>4</tpages></addata></record> |
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| subjects | Background levels Biomarkers Biomedical and Life Sciences Biomedicine Blood levels Body weight Cardiac muscle Cardiomyocytes Cardiovascular system Congestive heart failure Glomerular filtration rate Heart failure Human Physiology Immobilization Life Sciences Weightlessness |
| title | Influence of Factors of 21-Day Head-Down Bed Rest on the Blood Level of Myocardial Extensibility Biomarker ST2 |
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