Case Report: Evolutionary Clinical-Radiological Features of a Diffuse Hemispheric Glioma, H3 G34 Mutant with Over 5 Years of Survival
Abstract Diffuse hemispheric glioma (DHG), H3 G34 mutant was included in the 5th edition of the World Health Organization Classification of Tumors of the Central Nervous System recently published. Given the recent inclusion in the current classification and its rarity in adult patients, there are sc...
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| Veröffentlicht in: | Case Reports in Oncology 2023-01, Vol.16 (1), p.285-292 |
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| creator | Yamada, Camilla A.F. Soldatelli, Matheus Amaral, Lázaro Luis Faria do Campos, Christiane Monteiro de Siqueira Moraes, Paulo Lazaro de Chaddad-Neto, Feres Eduardo Aparecido Lancellotti, Carmen Lucia Penteado |
| description | Abstract
Diffuse hemispheric glioma (DHG), H3 G34 mutant was included in the 5th edition of the World Health Organization Classification of Tumors of the Central Nervous System recently published. Given the recent inclusion in the current classification and its rarity in adult patients, there are scarce data on clinical-radiological characteristics, survival, and outcome. The authors report the case of a 35-year-old female with DHG, H3 G34-mutant characteristics and outcomes with an unusual presentation, recurrence, and prolonged survival. In conclusion, our case report demonstrates relevant details that should be observed in patients with suspicion or confirmation of the diagnosis of DHG, H3 G34 mutant, not only in the initial presentation but also in the evolution to ensure more personalized treatment. |
| doi_str_mv | 10.1159/000530181 |
| format | Article |
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Diffuse hemispheric glioma (DHG), H3 G34 mutant was included in the 5th edition of the World Health Organization Classification of Tumors of the Central Nervous System recently published. Given the recent inclusion in the current classification and its rarity in adult patients, there are scarce data on clinical-radiological characteristics, survival, and outcome. The authors report the case of a 35-year-old female with DHG, H3 G34-mutant characteristics and outcomes with an unusual presentation, recurrence, and prolonged survival. In conclusion, our case report demonstrates relevant details that should be observed in patients with suspicion or confirmation of the diagnosis of DHG, H3 G34 mutant, not only in the initial presentation but also in the evolution to ensure more personalized treatment.</description><identifier>ISSN: 1662-6575</identifier><identifier>EISSN: 1662-6575</identifier><identifier>DOI: 10.1159/000530181</identifier><identifier>PMID: 37123609</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Blood ; Brain cancer ; brain tumor ; Calcification ; Care and treatment ; Case Report ; Case reports ; Diagnosis ; diffuse hemispheric glioma ; Genetic aspects ; Glioma ; Gliomas ; h3 g34 ; Magnetic resonance imaging ; Medical prognosis ; Morphology ; Mutation ; Patients ; Radiation therapy ; Tumors</subject><ispartof>Case Reports in Oncology, 2023-01, Vol.16 (1), p.285-292</ispartof><rights>2023 The Author(s). Published by S. Karger AG, Basel</rights><rights>2023 The Author(s). Published by S. Karger AG, Basel.</rights><rights>COPYRIGHT 2023 S. Karger AG</rights><rights>2023 The Author(s). Published by S. Karger AG, Basel. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at: https://uk.sagepub.com/en-gb/eur/reusing-open-access-and-sage-choice-content</rights><rights>2023 The Author(s). Published by S. Karger AG, Basel 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c553t-c2f118791709157f4608a88b9075d5637eb8c51888352bf643335cbe21caec263</citedby><cites>FETCH-LOGICAL-c553t-c2f118791709157f4608a88b9075d5637eb8c51888352bf643335cbe21caec263</cites><orcidid>0000-0003-2944-9947 ; 0000-0002-5882-2037</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134051/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134051/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,27612,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37123609$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamada, Camilla A.F.</creatorcontrib><creatorcontrib>Soldatelli, Matheus</creatorcontrib><creatorcontrib>Amaral, Lázaro Luis Faria do</creatorcontrib><creatorcontrib>Campos, Christiane Monteiro de Siqueira</creatorcontrib><creatorcontrib>Moraes, Paulo Lazaro de</creatorcontrib><creatorcontrib>Chaddad-Neto, Feres Eduardo Aparecido</creatorcontrib><creatorcontrib>Lancellotti, Carmen Lucia Penteado</creatorcontrib><title>Case Report: Evolutionary Clinical-Radiological Features of a Diffuse Hemispheric Glioma, H3 G34 Mutant with Over 5 Years of Survival</title><title>Case Reports in Oncology</title><addtitle>Case Rep Oncol</addtitle><description>Abstract
Diffuse hemispheric glioma (DHG), H3 G34 mutant was included in the 5th edition of the World Health Organization Classification of Tumors of the Central Nervous System recently published. Given the recent inclusion in the current classification and its rarity in adult patients, there are scarce data on clinical-radiological characteristics, survival, and outcome. The authors report the case of a 35-year-old female with DHG, H3 G34-mutant characteristics and outcomes with an unusual presentation, recurrence, and prolonged survival. In conclusion, our case report demonstrates relevant details that should be observed in patients with suspicion or confirmation of the diagnosis of DHG, H3 G34 mutant, not only in the initial presentation but also in the evolution to ensure more personalized treatment.</description><subject>Blood</subject><subject>Brain cancer</subject><subject>brain tumor</subject><subject>Calcification</subject><subject>Care and treatment</subject><subject>Case Report</subject><subject>Case reports</subject><subject>Diagnosis</subject><subject>diffuse hemispheric glioma</subject><subject>Genetic aspects</subject><subject>Glioma</subject><subject>Gliomas</subject><subject>h3 g34</subject><subject>Magnetic resonance imaging</subject><subject>Medical prognosis</subject><subject>Morphology</subject><subject>Mutation</subject><subject>Patients</subject><subject>Radiation therapy</subject><subject>Tumors</subject><issn>1662-6575</issn><issn>1662-6575</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptkk1vEzEQQFcIREvhwB0hS5yQSPH4e3tBVWiTSkWRAhw4WV6vnThs1sG7G8QP4H_jNCG0EvLB9vj5ecaaongJ-ByAl-8xxpxiUPCoOAUhyEhwyR_fW58Uz7puhbEoueBPixMqgVCBy9Pi99h0Ds3dJqb-Al1tYzP0IbYm_ULjJrTBmmY0N3WITVzsNujamX5IrkPRI4M-Bu-HLJi6deg2S5eCRZMmxLV5h6YUTShDn4betD36Gfolmm1dQhx9cybdCT4PaRu2pnlePPGm6dyLw3xWfL2--jKejm5nk5vx5e3Ick77kSUeQMkSJC6BS88EVkapqsSS11xQ6SplOSilKCeVF4xSym3lCFjjLBH0rLjZe-toVnqTwjoXqqMJ-i4Q00Kb1AfbOM0rzgjH3EgAxhgtQciyBs-sKyuwMrs-7F2boVq72rq2T6Z5IH140oalXsStBgyUYQ7Z8OZgSPHH4Lper-KQ2vwBmpSYgSo54Zk631MLk9MKrY_ZZvOo85_b2DofcvxSSqEYIWynfbu_YFPsuuT8MSfAetcv-tgvmX19v4gj-bdB_uX43aSFS0dgPJ_tFXpT-0y9-i91eOUPGzHM5A</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Yamada, Camilla A.F.</creator><creator>Soldatelli, Matheus</creator><creator>Amaral, Lázaro Luis Faria do</creator><creator>Campos, Christiane Monteiro de Siqueira</creator><creator>Moraes, Paulo Lazaro de</creator><creator>Chaddad-Neto, Feres Eduardo Aparecido</creator><creator>Lancellotti, Carmen Lucia Penteado</creator><general>S. 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Diffuse hemispheric glioma (DHG), H3 G34 mutant was included in the 5th edition of the World Health Organization Classification of Tumors of the Central Nervous System recently published. Given the recent inclusion in the current classification and its rarity in adult patients, there are scarce data on clinical-radiological characteristics, survival, and outcome. The authors report the case of a 35-year-old female with DHG, H3 G34-mutant characteristics and outcomes with an unusual presentation, recurrence, and prolonged survival. In conclusion, our case report demonstrates relevant details that should be observed in patients with suspicion or confirmation of the diagnosis of DHG, H3 G34 mutant, not only in the initial presentation but also in the evolution to ensure more personalized treatment.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>37123609</pmid><doi>10.1159/000530181</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-2944-9947</orcidid><orcidid>https://orcid.org/0000-0002-5882-2037</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Blood Brain cancer brain tumor Calcification Care and treatment Case Report Case reports Diagnosis diffuse hemispheric glioma Genetic aspects Glioma Gliomas h3 g34 Magnetic resonance imaging Medical prognosis Morphology Mutation Patients Radiation therapy Tumors |
| title | Case Report: Evolutionary Clinical-Radiological Features of a Diffuse Hemispheric Glioma, H3 G34 Mutant with Over 5 Years of Survival |
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