38 Fine Motor Skills in Pediatric Frontal Lobe Epilepsy are Associated with Executive Dysfunction and ADHD Symptomatology
Objective:Pediatric patients with frontal lobe epilepsy (FLE) have higher rates of attention deficit hyperactivity disorder (ADHD), as well as executive functioning (EF) and fine motor (FM) challenges. Relations between these constructs have been established in youth with ADHD and are supported by F...
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| Veröffentlicht in: | Journal of the International Neuropsychological Society 2023-11, Vol.29 (s1), p.37-38 |
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| creator | Maiman, Moshe Berl, Madison Koop, Jennifer I Bearden, Donald J Boyer, Katrina Cooper, Crystal M Decrow, Amanda M Duong, Priscilla H. Espe-Pfeifer, Patricia Gabriel, Marsha Hodges, Elise McNally, Kelly A Molnar, Andrew Olsen, Emily Ono, Kim E Patrick, Kristina E Paul, Brianna Romain, Jonathan Sepeta, Leigh N Stilp, Rebecca LH Wilkening, Greta N Zaccariello, Mike Zelko, Frank Vega, Clemente Moore, Trey Mulati, Szimonetta Pearl, Phillip Bolton, Jeffrey Ailion, Alyssa |
| description | Objective:Pediatric patients with frontal lobe epilepsy (FLE) have higher rates of attention deficit hyperactivity disorder (ADHD), as well as executive functioning (EF) and fine motor (FM) challenges. Relations between these constructs have been established in youth with ADHD and are supported by FM and EF skill involvement in frontal-subcortical systems. Still, they are not well understood in pediatric FLE. We hypothesized that poorer FM performance would be related to greater executive dysfunction and ADHD symptomatology in this group.Participants and Methods:47 children and adolescents with FLE (AgeM=12.47, SD=5.18; IQM=84.07; SD=17.56; Age of Seizure OnsetM=6.85, SD=4.64; right-handed: n=34; left-handed: n=10; Unclear: n=3) were enrolled in the Pediatric Epilepsy Research Consortium dataset as part of their phase I epilepsy surgical evaluation. Participants were selected if they had unifocal FLE and completed the Lafayette Grooved Pegboard (GP). Seizure lateralization (left-sided: n=19; right-sided: n=26; bilateral: n=2) and localization were established via data (e.g., EEG, MRI) presented at a multidisciplinary team case conference. Patients completed neuropsychological measures of FM, attention, and EF. Parents also completed questionnaires inquiring about their child’s everyday EF and ADHD symptomatology. Correlational analyses were conducted to examine FM, EF, and ADHD relations.Results:Dominant hand (DH) manual dexterity (GP) was related to parent-reported EF (Behavior Rating Inventory of Executive Function, Second Edition [BRIEF-2]-Global Executive Composite [GEC]: r(15) =-.70, p |
| doi_str_mv | 10.1017/S1355617723001200 |
| format | Article |
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Relations between these constructs have been established in youth with ADHD and are supported by FM and EF skill involvement in frontal-subcortical systems. Still, they are not well understood in pediatric FLE. We hypothesized that poorer FM performance would be related to greater executive dysfunction and ADHD symptomatology in this group.Participants and Methods:47 children and adolescents with FLE (AgeM=12.47, SD=5.18; IQM=84.07; SD=17.56; Age of Seizure OnsetM=6.85, SD=4.64; right-handed: n=34; left-handed: n=10; Unclear: n=3) were enrolled in the Pediatric Epilepsy Research Consortium dataset as part of their phase I epilepsy surgical evaluation. Participants were selected if they had unifocal FLE and completed the Lafayette Grooved Pegboard (GP). Seizure lateralization (left-sided: n=19; right-sided: n=26; bilateral: n=2) and localization were established via data (e.g., EEG, MRI) presented at a multidisciplinary team case conference. Patients completed neuropsychological measures of FM, attention, and EF. Parents also completed questionnaires inquiring about their child’s everyday EF and ADHD symptomatology. Correlational analyses were conducted to examine FM, EF, and ADHD relations.Results:Dominant hand (DH) manual dexterity (GP) was related to parent-reported EF (Behavior Rating Inventory of Executive Function, Second Edition [BRIEF-2]-Global Executive Composite [GEC]: r(15) =-.70, p<.01, d=1.96). While not statistically significant, medium to large effect sizes were found for GP DH and parent-reported inattention (Behavior Assessment System for Children, Third Edition [BASC-3]-Attention Problems: r(12)=-.39, p=.17, d=.85) and hyperactivity/impulsivity (BASC-3-Hyperactivity: r(11)= -.44, p=.13, d=.98), as well as performance-based attention (Conners Continuous Performance Test, Third Edition -Omission Errors: r(12)=-.35, p=.22, d=.41), working memory (Wechsler Intelligence Scale for Children - Fifth Edition [WISC-V]-Digit Span [DS]: r(19)=.38, p=.09, d=.82) and cognitive flexibility (Delis-Kaplan Executive Function System (D-KEFS) Verbal Fluency Category Switching: r(13)=.46, p=.08, d=1.04); this suggests that these relations may exist but that our study was underpowered to detect them. Non-dominant hand (NDH) manual dexterity was related to performance-based working memory (WISC-V-DS: r(19)=.50, p<.01, d=1.12) and cognitive flexibility (D-KEFS-Trails Making Test Number-Letter Switching: r(17)=.64, p<.01, d=1.67). Again, while underpowered, medium to large effect sizes were found for GP NDH and parent-reported EF (BRIEF-2 GEC: r(15) =-.45, p=.07, d=1.01) and performance-based phonemic fluency (D-KEFS-Letter Fluency: r(13)=.31, p=.20, d=.65).Conclusions:Our findings suggest that FM, EF, and ADHD are related in youth with FLE; however, these relations appear to vary by skill and hand. We posit that our findings are due in part to the frontal-cerebellar networks given their anatomic proximity between frontal motor areas and the dorsolateral prefrontal cortex - as well as their shared functional involvement in these networks. Future studies should evaluate the predictive validity of initial FM skills for later executive dysfunction and ADHD symptomatology in FLE. If such relations emerge, contributions of early FM interventions on EF development should be examined. Further replication of these findings with a larger sample is warranted.</description><identifier>ISSN: 1355-6177</identifier><identifier>EISSN: 1469-7661</identifier><identifier>DOI: 10.1017/S1355617723001200</identifier><language>eng</language><publisher>New York, USA: Cambridge University Press</publisher><subject>Attention deficit hyperactivity disorder ; Cerebellum ; Children ; Cognitive ability ; Convulsions & seizures ; Epilepsy ; Epilepsy/Seizures ; Executive function ; Frontal lobe ; Hand ; Handedness ; Hemispheric laterality ; Hyperactivity ; Impulsive behavior ; Localization ; Memory ; Motor ability ; Motor skill ; Pediatrics ; Poster Session 01: Medical | Neurological Disorders | Neuropsychiatry | Psychopharmacology ; Prefrontal cortex ; Seizures ; Short term memory ; Skills ; Statistical analysis</subject><ispartof>Journal of the International Neuropsychological Society, 2023-11, Vol.29 (s1), p.37-38</ispartof><rights>Copyright © INS. Published by Cambridge University Press, 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S1355617723001200/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids></links><search><creatorcontrib>Maiman, Moshe</creatorcontrib><creatorcontrib>Berl, Madison</creatorcontrib><creatorcontrib>Koop, Jennifer I</creatorcontrib><creatorcontrib>Bearden, Donald J</creatorcontrib><creatorcontrib>Boyer, Katrina</creatorcontrib><creatorcontrib>Cooper, Crystal M</creatorcontrib><creatorcontrib>Decrow, Amanda M</creatorcontrib><creatorcontrib>Duong, Priscilla H.</creatorcontrib><creatorcontrib>Espe-Pfeifer, Patricia</creatorcontrib><creatorcontrib>Gabriel, Marsha</creatorcontrib><creatorcontrib>Hodges, Elise</creatorcontrib><creatorcontrib>McNally, Kelly A</creatorcontrib><creatorcontrib>Molnar, Andrew</creatorcontrib><creatorcontrib>Olsen, Emily</creatorcontrib><creatorcontrib>Ono, Kim E</creatorcontrib><creatorcontrib>Patrick, Kristina E</creatorcontrib><creatorcontrib>Paul, Brianna</creatorcontrib><creatorcontrib>Romain, Jonathan</creatorcontrib><creatorcontrib>Sepeta, Leigh N</creatorcontrib><creatorcontrib>Stilp, Rebecca LH</creatorcontrib><creatorcontrib>Wilkening, Greta N</creatorcontrib><creatorcontrib>Zaccariello, Mike</creatorcontrib><creatorcontrib>Zelko, Frank</creatorcontrib><creatorcontrib>Vega, Clemente</creatorcontrib><creatorcontrib>Moore, Trey</creatorcontrib><creatorcontrib>Mulati, Szimonetta</creatorcontrib><creatorcontrib>Pearl, Phillip</creatorcontrib><creatorcontrib>Bolton, Jeffrey</creatorcontrib><creatorcontrib>Ailion, Alyssa</creatorcontrib><title>38 Fine Motor Skills in Pediatric Frontal Lobe Epilepsy are Associated with Executive Dysfunction and ADHD Symptomatology</title><title>Journal of the International Neuropsychological Society</title><addtitle>J Int Neuropsychol Soc</addtitle><description>Objective:Pediatric patients with frontal lobe epilepsy (FLE) have higher rates of attention deficit hyperactivity disorder (ADHD), as well as executive functioning (EF) and fine motor (FM) challenges. Relations between these constructs have been established in youth with ADHD and are supported by FM and EF skill involvement in frontal-subcortical systems. Still, they are not well understood in pediatric FLE. We hypothesized that poorer FM performance would be related to greater executive dysfunction and ADHD symptomatology in this group.Participants and Methods:47 children and adolescents with FLE (AgeM=12.47, SD=5.18; IQM=84.07; SD=17.56; Age of Seizure OnsetM=6.85, SD=4.64; right-handed: n=34; left-handed: n=10; Unclear: n=3) were enrolled in the Pediatric Epilepsy Research Consortium dataset as part of their phase I epilepsy surgical evaluation. Participants were selected if they had unifocal FLE and completed the Lafayette Grooved Pegboard (GP). Seizure lateralization (left-sided: n=19; right-sided: n=26; bilateral: n=2) and localization were established via data (e.g., EEG, MRI) presented at a multidisciplinary team case conference. Patients completed neuropsychological measures of FM, attention, and EF. Parents also completed questionnaires inquiring about their child’s everyday EF and ADHD symptomatology. Correlational analyses were conducted to examine FM, EF, and ADHD relations.Results:Dominant hand (DH) manual dexterity (GP) was related to parent-reported EF (Behavior Rating Inventory of Executive Function, Second Edition [BRIEF-2]-Global Executive Composite [GEC]: r(15) =-.70, p<.01, d=1.96). While not statistically significant, medium to large effect sizes were found for GP DH and parent-reported inattention (Behavior Assessment System for Children, Third Edition [BASC-3]-Attention Problems: r(12)=-.39, p=.17, d=.85) and hyperactivity/impulsivity (BASC-3-Hyperactivity: r(11)= -.44, p=.13, d=.98), as well as performance-based attention (Conners Continuous Performance Test, Third Edition -Omission Errors: r(12)=-.35, p=.22, d=.41), working memory (Wechsler Intelligence Scale for Children - Fifth Edition [WISC-V]-Digit Span [DS]: r(19)=.38, p=.09, d=.82) and cognitive flexibility (Delis-Kaplan Executive Function System (D-KEFS) Verbal Fluency Category Switching: r(13)=.46, p=.08, d=1.04); this suggests that these relations may exist but that our study was underpowered to detect them. Non-dominant hand (NDH) manual dexterity was related to performance-based working memory (WISC-V-DS: r(19)=.50, p<.01, d=1.12) and cognitive flexibility (D-KEFS-Trails Making Test Number-Letter Switching: r(17)=.64, p<.01, d=1.67). Again, while underpowered, medium to large effect sizes were found for GP NDH and parent-reported EF (BRIEF-2 GEC: r(15) =-.45, p=.07, d=1.01) and performance-based phonemic fluency (D-KEFS-Letter Fluency: r(13)=.31, p=.20, d=.65).Conclusions:Our findings suggest that FM, EF, and ADHD are related in youth with FLE; however, these relations appear to vary by skill and hand. We posit that our findings are due in part to the frontal-cerebellar networks given their anatomic proximity between frontal motor areas and the dorsolateral prefrontal cortex - as well as their shared functional involvement in these networks. Future studies should evaluate the predictive validity of initial FM skills for later executive dysfunction and ADHD symptomatology in FLE. If such relations emerge, contributions of early FM interventions on EF development should be examined. Further replication of these findings with a larger sample is warranted.</description><subject>Attention deficit hyperactivity disorder</subject><subject>Cerebellum</subject><subject>Children</subject><subject>Cognitive ability</subject><subject>Convulsions & seizures</subject><subject>Epilepsy</subject><subject>Epilepsy/Seizures</subject><subject>Executive function</subject><subject>Frontal lobe</subject><subject>Hand</subject><subject>Handedness</subject><subject>Hemispheric laterality</subject><subject>Hyperactivity</subject><subject>Impulsive behavior</subject><subject>Localization</subject><subject>Memory</subject><subject>Motor ability</subject><subject>Motor skill</subject><subject>Pediatrics</subject><subject>Poster Session 01: Medical | Neurological Disorders | Neuropsychiatry | Psychopharmacology</subject><subject>Prefrontal cortex</subject><subject>Seizures</subject><subject>Short term memory</subject><subject>Skills</subject><subject>Statistical analysis</subject><issn>1355-6177</issn><issn>1469-7661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kM1OwzAQhCMEEqXwANwscQ7YcWInx6o_FKkIpMI5cu1NcUniYDtA3h5XrcQBcdpdzTe72omia4JvCSb8bk1oljHCeUIxJgnGJ9GIpKyIOWPkNPRBjvf6eXTh3C4wlGA8igaao4VuAT0abyxav-u6dki36BmUFt5qiRbWtF7UaGU2gOadrqFzAxIW0MQ5IwMFCn1p_4bm3yB7rz8BzQZX9a302rRItApNZssZWg9N500jvKnNdriMzipRO7g61nH0upi_TJfx6un-YTpZxZJkHMd5qlhFOFDJKKYUUg5FAVUOJA8Py5QBZzjPcBhppgpgecoTkaoNS_NEiYSOo5vD3s6ajx6cL3emt204WSYFTvchZUWgyIGS1jhnoSo7qxthh5Lgcp9w-Sfh4KFHj2g2Vqst_K7-3_UDSAx8BA</recordid><startdate>202311</startdate><enddate>202311</enddate><creator>Maiman, Moshe</creator><creator>Berl, Madison</creator><creator>Koop, Jennifer I</creator><creator>Bearden, Donald J</creator><creator>Boyer, Katrina</creator><creator>Cooper, Crystal M</creator><creator>Decrow, Amanda M</creator><creator>Duong, Priscilla H.</creator><creator>Espe-Pfeifer, Patricia</creator><creator>Gabriel, Marsha</creator><creator>Hodges, Elise</creator><creator>McNally, Kelly A</creator><creator>Molnar, Andrew</creator><creator>Olsen, Emily</creator><creator>Ono, Kim E</creator><creator>Patrick, Kristina E</creator><creator>Paul, Brianna</creator><creator>Romain, Jonathan</creator><creator>Sepeta, Leigh N</creator><creator>Stilp, Rebecca LH</creator><creator>Wilkening, Greta N</creator><creator>Zaccariello, Mike</creator><creator>Zelko, Frank</creator><creator>Vega, Clemente</creator><creator>Moore, Trey</creator><creator>Mulati, Szimonetta</creator><creator>Pearl, Phillip</creator><creator>Bolton, Jeffrey</creator><creator>Ailion, Alyssa</creator><general>Cambridge University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>202311</creationdate><title>38 Fine Motor Skills in Pediatric Frontal Lobe Epilepsy are Associated with Executive Dysfunction and ADHD Symptomatology</title><author>Maiman, Moshe ; Berl, Madison ; Koop, Jennifer I ; Bearden, Donald J ; Boyer, Katrina ; Cooper, Crystal M ; Decrow, Amanda M ; Duong, Priscilla H. ; Espe-Pfeifer, Patricia ; Gabriel, Marsha ; Hodges, Elise ; McNally, Kelly A ; Molnar, Andrew ; Olsen, Emily ; Ono, Kim E ; Patrick, Kristina E ; Paul, Brianna ; Romain, Jonathan ; Sepeta, Leigh N ; Stilp, Rebecca LH ; Wilkening, Greta N ; Zaccariello, Mike ; Zelko, Frank ; Vega, Clemente ; Moore, Trey ; Mulati, Szimonetta ; Pearl, Phillip ; Bolton, Jeffrey ; Ailion, Alyssa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1570-84d6f17e3c63033e47e99ef8e18556c46e76085018535d9e68472a4db6482da23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Attention deficit hyperactivity disorder</topic><topic>Cerebellum</topic><topic>Children</topic><topic>Cognitive ability</topic><topic>Convulsions & seizures</topic><topic>Epilepsy</topic><topic>Epilepsy/Seizures</topic><topic>Executive function</topic><topic>Frontal lobe</topic><topic>Hand</topic><topic>Handedness</topic><topic>Hemispheric laterality</topic><topic>Hyperactivity</topic><topic>Impulsive behavior</topic><topic>Localization</topic><topic>Memory</topic><topic>Motor ability</topic><topic>Motor skill</topic><topic>Pediatrics</topic><topic>Poster Session 01: Medical | Neurological Disorders | Neuropsychiatry | Psychopharmacology</topic><topic>Prefrontal cortex</topic><topic>Seizures</topic><topic>Short term memory</topic><topic>Skills</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maiman, Moshe</creatorcontrib><creatorcontrib>Berl, Madison</creatorcontrib><creatorcontrib>Koop, Jennifer I</creatorcontrib><creatorcontrib>Bearden, Donald J</creatorcontrib><creatorcontrib>Boyer, Katrina</creatorcontrib><creatorcontrib>Cooper, Crystal M</creatorcontrib><creatorcontrib>Decrow, Amanda M</creatorcontrib><creatorcontrib>Duong, Priscilla H.</creatorcontrib><creatorcontrib>Espe-Pfeifer, Patricia</creatorcontrib><creatorcontrib>Gabriel, Marsha</creatorcontrib><creatorcontrib>Hodges, Elise</creatorcontrib><creatorcontrib>McNally, Kelly A</creatorcontrib><creatorcontrib>Molnar, Andrew</creatorcontrib><creatorcontrib>Olsen, Emily</creatorcontrib><creatorcontrib>Ono, Kim E</creatorcontrib><creatorcontrib>Patrick, Kristina E</creatorcontrib><creatorcontrib>Paul, Brianna</creatorcontrib><creatorcontrib>Romain, Jonathan</creatorcontrib><creatorcontrib>Sepeta, Leigh N</creatorcontrib><creatorcontrib>Stilp, Rebecca LH</creatorcontrib><creatorcontrib>Wilkening, Greta N</creatorcontrib><creatorcontrib>Zaccariello, Mike</creatorcontrib><creatorcontrib>Zelko, Frank</creatorcontrib><creatorcontrib>Vega, Clemente</creatorcontrib><creatorcontrib>Moore, Trey</creatorcontrib><creatorcontrib>Mulati, Szimonetta</creatorcontrib><creatorcontrib>Pearl, Phillip</creatorcontrib><creatorcontrib>Bolton, Jeffrey</creatorcontrib><creatorcontrib>Ailion, Alyssa</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences 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(Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Journal of the International Neuropsychological Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maiman, Moshe</au><au>Berl, Madison</au><au>Koop, Jennifer I</au><au>Bearden, Donald J</au><au>Boyer, Katrina</au><au>Cooper, Crystal M</au><au>Decrow, Amanda M</au><au>Duong, Priscilla H.</au><au>Espe-Pfeifer, Patricia</au><au>Gabriel, Marsha</au><au>Hodges, Elise</au><au>McNally, Kelly A</au><au>Molnar, Andrew</au><au>Olsen, Emily</au><au>Ono, Kim E</au><au>Patrick, Kristina E</au><au>Paul, Brianna</au><au>Romain, Jonathan</au><au>Sepeta, Leigh N</au><au>Stilp, Rebecca LH</au><au>Wilkening, Greta N</au><au>Zaccariello, Mike</au><au>Zelko, Frank</au><au>Vega, Clemente</au><au>Moore, Trey</au><au>Mulati, Szimonetta</au><au>Pearl, Phillip</au><au>Bolton, Jeffrey</au><au>Ailion, Alyssa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>38 Fine Motor Skills in Pediatric Frontal Lobe Epilepsy are Associated with Executive Dysfunction and ADHD Symptomatology</atitle><jtitle>Journal of the International Neuropsychological Society</jtitle><addtitle>J Int Neuropsychol Soc</addtitle><date>2023-11</date><risdate>2023</risdate><volume>29</volume><issue>s1</issue><spage>37</spage><epage>38</epage><pages>37-38</pages><issn>1355-6177</issn><eissn>1469-7661</eissn><abstract>Objective:Pediatric patients with frontal lobe epilepsy (FLE) have higher rates of attention deficit hyperactivity disorder (ADHD), as well as executive functioning (EF) and fine motor (FM) challenges. Relations between these constructs have been established in youth with ADHD and are supported by FM and EF skill involvement in frontal-subcortical systems. Still, they are not well understood in pediatric FLE. We hypothesized that poorer FM performance would be related to greater executive dysfunction and ADHD symptomatology in this group.Participants and Methods:47 children and adolescents with FLE (AgeM=12.47, SD=5.18; IQM=84.07; SD=17.56; Age of Seizure OnsetM=6.85, SD=4.64; right-handed: n=34; left-handed: n=10; Unclear: n=3) were enrolled in the Pediatric Epilepsy Research Consortium dataset as part of their phase I epilepsy surgical evaluation. Participants were selected if they had unifocal FLE and completed the Lafayette Grooved Pegboard (GP). Seizure lateralization (left-sided: n=19; right-sided: n=26; bilateral: n=2) and localization were established via data (e.g., EEG, MRI) presented at a multidisciplinary team case conference. Patients completed neuropsychological measures of FM, attention, and EF. Parents also completed questionnaires inquiring about their child’s everyday EF and ADHD symptomatology. Correlational analyses were conducted to examine FM, EF, and ADHD relations.Results:Dominant hand (DH) manual dexterity (GP) was related to parent-reported EF (Behavior Rating Inventory of Executive Function, Second Edition [BRIEF-2]-Global Executive Composite [GEC]: r(15) =-.70, p<.01, d=1.96). While not statistically significant, medium to large effect sizes were found for GP DH and parent-reported inattention (Behavior Assessment System for Children, Third Edition [BASC-3]-Attention Problems: r(12)=-.39, p=.17, d=.85) and hyperactivity/impulsivity (BASC-3-Hyperactivity: r(11)= -.44, p=.13, d=.98), as well as performance-based attention (Conners Continuous Performance Test, Third Edition -Omission Errors: r(12)=-.35, p=.22, d=.41), working memory (Wechsler Intelligence Scale for Children - Fifth Edition [WISC-V]-Digit Span [DS]: r(19)=.38, p=.09, d=.82) and cognitive flexibility (Delis-Kaplan Executive Function System (D-KEFS) Verbal Fluency Category Switching: r(13)=.46, p=.08, d=1.04); this suggests that these relations may exist but that our study was underpowered to detect them. Non-dominant hand (NDH) manual dexterity was related to performance-based working memory (WISC-V-DS: r(19)=.50, p<.01, d=1.12) and cognitive flexibility (D-KEFS-Trails Making Test Number-Letter Switching: r(17)=.64, p<.01, d=1.67). Again, while underpowered, medium to large effect sizes were found for GP NDH and parent-reported EF (BRIEF-2 GEC: r(15) =-.45, p=.07, d=1.01) and performance-based phonemic fluency (D-KEFS-Letter Fluency: r(13)=.31, p=.20, d=.65).Conclusions:Our findings suggest that FM, EF, and ADHD are related in youth with FLE; however, these relations appear to vary by skill and hand. We posit that our findings are due in part to the frontal-cerebellar networks given their anatomic proximity between frontal motor areas and the dorsolateral prefrontal cortex - as well as their shared functional involvement in these networks. Future studies should evaluate the predictive validity of initial FM skills for later executive dysfunction and ADHD symptomatology in FLE. If such relations emerge, contributions of early FM interventions on EF development should be examined. Further replication of these findings with a larger sample is warranted.</abstract><cop>New York, USA</cop><pub>Cambridge University Press</pub><doi>10.1017/S1355617723001200</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1355-6177 |
| ispartof | Journal of the International Neuropsychological Society, 2023-11, Vol.29 (s1), p.37-38 |
| issn | 1355-6177 1469-7661 |
| language | eng |
| recordid | cdi_proquest_journals_2904146959 |
| source | Cambridge University Press Journals |
| subjects | Attention deficit hyperactivity disorder Cerebellum Children Cognitive ability Convulsions & seizures Epilepsy Epilepsy/Seizures Executive function Frontal lobe Hand Handedness Hemispheric laterality Hyperactivity Impulsive behavior Localization Memory Motor ability Motor skill Pediatrics Poster Session 01: Medical | Neurological Disorders | Neuropsychiatry | Psychopharmacology Prefrontal cortex Seizures Short term memory Skills Statistical analysis |
| title | 38 Fine Motor Skills in Pediatric Frontal Lobe Epilepsy are Associated with Executive Dysfunction and ADHD Symptomatology |
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