Development of a 2nd Generation Process for 3‐Ethyl‐4‐Hydroxy‐5‐Methylbenzonitrile – A Key Building Block of S1P1 Receptor Modulator Cenerimod – through a Non‐Classical Nitrile Formation Using Hydroxylamine‐O‐sulfonic Acid (HOSA)

A new, improved 2nd generation route for the synthesis of 3‐ethyl‐4‐hydroxy‐5‐methylbenzonitrile has been developed. The original route started from 2‐ethyl‐6‐methylaniline, which was converted by a classical sequence of para‐bromination, cyanation and Sandmeyer hydroxylation into the desired phenol...

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Veröffentlicht in:	Helvetica chimica acta 2023-12, Vol.106 (12), p.n/a
Hauptverfasser:	Schäfer, Gabriel, Fleischer, Tony
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Bromination CPME Duff reaction formylation HOSA Hydroxylamine Hydroxylation industrial chemistry Phenols Purity Safety critical Sandmeyer reaction Sulfonic acid synthetic methods
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