The ‘Pants-Sign’: A Predictor for Falling in People with Parkinson’s Disease?
Background: A history of falls is the most established predictor of future falls in people with Parkinson’s disease (PD). However, predicting a first fall remains challenging. Objective: To assess whether experiencing difficulties putting on pants while standing is a viable predictor of future falli...
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| Veröffentlicht in: | Journal of Parkinson's disease 2023-01, Vol.13 (8), p.1321-1327 |
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| container_title | Journal of Parkinson's disease |
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| creator | Jansen, Jamie A.F. Tosserams, Anouk Weerdesteyn, Vivian G.M. Bloem, Bastiaan R. Nonnekes, Jorik |
| description | Background:
A history of falls is the most established predictor of future falls in people with Parkinson’s disease (PD). However, predicting a first fall remains challenging.
Objective:
To assess whether experiencing difficulties putting on pants while standing is a viable predictor of future falling, and specifically a first fall, in persons with PD. We define this ‘Pants-sign’ as people who resort to putting on their pants only while seated.
Methods:
264 persons with PD were included. Information on the Pants-sign, history of falls, disease severity (MDS-UPDRS part III), freezing of gait (N-FOGQ > 0), cognitive function (MoCA), self-reported disability (Schwab & England scale), health-related quality of life (SF-12), Timed-Up-and-Go, and one-legged stance were determined at baseline and after one-year follow-up. The association between the Pants-sign and future falling was examined by univariate logistic regression analysis. A multivariate step-wise logistic regression with forward selection was employed to identify the strongest associations in the entire cohort and a sub-cohort of people without falls in the year prior to baseline.
Results:
The Pants-sign was univariably associated with a future fall (OR = 2.406, 95% CI [1.313–4.409], p = 0.004]), but was not an independent predictor in the multivariate logistic regression; predictors were higher MDS-UPDRS part III scores (OR = 1.088, 95% CI [1.056–1.121], p |
| doi_str_mv | 10.3233/JPD-230353 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2903552095</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.3233_JPD-230353</sage_id><sourcerecordid>2903552095</sourcerecordid><originalsourceid>FETCH-LOGICAL-c342t-e385ecd3b29313dd9e73e5bb59c093bf13cf5b7e7bc6bb53df3f967774ace8283</originalsourceid><addsrcrecordid>eNptkM9Kw0AQhxdRrNRefAAJeBCEaHanm028SGmtfygYsIK3sNlM2tQ2qbsp4q2PoTefxUfpk7gltV5cGHYYvvkNfIQcUe8cGMDFfdRzGXjAYYcc0EAIV9DgeXfbC9ogLWMmnn2c-nZnnzQgoF4APjsgw-EYndXyI5JFZdzHfFSslp-XTseJNKa5qkrtZLb6cjrNi5GTF99fEZbzKTpveTV2Iqlf8sKU6y3j9HKD0uDVIdnL5NRga_M3yVP_eti9dQcPN3fdzsBV0GaVixBwVCkkLAQKaRqiAORJwkPlhZBkFFTGE4EiUb6dQppBFvpCiLZUGLAAmuSkzp3r8nWBpoon5UIX9mTMQquEMy_kljqrKaVLYzRm8VznM6nfY-rFa4exdRjXDi18vIlcJDNMt-ivMQuc1oCRI_y790_UD9tYemc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2903552095</pqid></control><display><type>article</type><title>The ‘Pants-Sign’: A Predictor for Falling in People with Parkinson’s Disease?</title><source>MEDLINE</source><source>Directory of Open Access Journals</source><creator>Jansen, Jamie A.F. ; Tosserams, Anouk ; Weerdesteyn, Vivian G.M. ; Bloem, Bastiaan R. ; Nonnekes, Jorik</creator><creatorcontrib>Jansen, Jamie A.F. ; Tosserams, Anouk ; Weerdesteyn, Vivian G.M. ; Bloem, Bastiaan R. ; Nonnekes, Jorik</creatorcontrib><description>Background:
A history of falls is the most established predictor of future falls in people with Parkinson’s disease (PD). However, predicting a first fall remains challenging.
Objective:
To assess whether experiencing difficulties putting on pants while standing is a viable predictor of future falling, and specifically a first fall, in persons with PD. We define this ‘Pants-sign’ as people who resort to putting on their pants only while seated.
Methods:
264 persons with PD were included. Information on the Pants-sign, history of falls, disease severity (MDS-UPDRS part III), freezing of gait (N-FOGQ > 0), cognitive function (MoCA), self-reported disability (Schwab & England scale), health-related quality of life (SF-12), Timed-Up-and-Go, and one-legged stance were determined at baseline and after one-year follow-up. The association between the Pants-sign and future falling was examined by univariate logistic regression analysis. A multivariate step-wise logistic regression with forward selection was employed to identify the strongest associations in the entire cohort and a sub-cohort of people without falls in the year prior to baseline.
Results:
The Pants-sign was univariably associated with a future fall (OR = 2.406, 95% CI [1.313–4.409], p = 0.004]), but was not an independent predictor in the multivariate logistic regression; predictors were higher MDS-UPDRS part III scores (OR = 1.088, 95% CI [1.056–1.121], p < 0.001] and history of falls (OR = 5.696, 95% CI [2.650–12.243], p≤0.001]. For the sub-cohort of people without falls in the previous year (n = 189), the Pants-sign was not associated with future falls.
Conclusions:
The Pants-sign is simple to assess and is associated with future falling in PD but is not an independent predictor.</description><identifier>ISSN: 1877-7171</identifier><identifier>EISSN: 1877-718X</identifier><identifier>DOI: 10.3233/JPD-230353</identifier><identifier>PMID: 38108362</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Cognitive ability ; Gait Disorders, Neurologic - complications ; Humans ; Movement disorders ; Neurodegenerative diseases ; Parkinson Disease - complications ; Parkinson's disease ; Physical Therapy Modalities ; Postural Balance ; Quality of Life ; Regression analysis</subject><ispartof>Journal of Parkinson's disease, 2023-01, Vol.13 (8), p.1321-1327</ispartof><rights>2023 – The authors. Published by IOS Press</rights><rights>Copyright IOS Press BV 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c342t-e385ecd3b29313dd9e73e5bb59c093bf13cf5b7e7bc6bb53df3f967774ace8283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38108362$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jansen, Jamie A.F.</creatorcontrib><creatorcontrib>Tosserams, Anouk</creatorcontrib><creatorcontrib>Weerdesteyn, Vivian G.M.</creatorcontrib><creatorcontrib>Bloem, Bastiaan R.</creatorcontrib><creatorcontrib>Nonnekes, Jorik</creatorcontrib><title>The ‘Pants-Sign’: A Predictor for Falling in People with Parkinson’s Disease?</title><title>Journal of Parkinson's disease</title><addtitle>J Parkinsons Dis</addtitle><description>Background:
A history of falls is the most established predictor of future falls in people with Parkinson’s disease (PD). However, predicting a first fall remains challenging.
Objective:
To assess whether experiencing difficulties putting on pants while standing is a viable predictor of future falling, and specifically a first fall, in persons with PD. We define this ‘Pants-sign’ as people who resort to putting on their pants only while seated.
Methods:
264 persons with PD were included. Information on the Pants-sign, history of falls, disease severity (MDS-UPDRS part III), freezing of gait (N-FOGQ > 0), cognitive function (MoCA), self-reported disability (Schwab & England scale), health-related quality of life (SF-12), Timed-Up-and-Go, and one-legged stance were determined at baseline and after one-year follow-up. The association between the Pants-sign and future falling was examined by univariate logistic regression analysis. A multivariate step-wise logistic regression with forward selection was employed to identify the strongest associations in the entire cohort and a sub-cohort of people without falls in the year prior to baseline.
Results:
The Pants-sign was univariably associated with a future fall (OR = 2.406, 95% CI [1.313–4.409], p = 0.004]), but was not an independent predictor in the multivariate logistic regression; predictors were higher MDS-UPDRS part III scores (OR = 1.088, 95% CI [1.056–1.121], p < 0.001] and history of falls (OR = 5.696, 95% CI [2.650–12.243], p≤0.001]. For the sub-cohort of people without falls in the previous year (n = 189), the Pants-sign was not associated with future falls.
Conclusions:
The Pants-sign is simple to assess and is associated with future falling in PD but is not an independent predictor.</description><subject>Cognitive ability</subject><subject>Gait Disorders, Neurologic - complications</subject><subject>Humans</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson's disease</subject><subject>Physical Therapy Modalities</subject><subject>Postural Balance</subject><subject>Quality of Life</subject><subject>Regression analysis</subject><issn>1877-7171</issn><issn>1877-718X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><recordid>eNptkM9Kw0AQhxdRrNRefAAJeBCEaHanm028SGmtfygYsIK3sNlM2tQ2qbsp4q2PoTefxUfpk7gltV5cGHYYvvkNfIQcUe8cGMDFfdRzGXjAYYcc0EAIV9DgeXfbC9ogLWMmnn2c-nZnnzQgoF4APjsgw-EYndXyI5JFZdzHfFSslp-XTseJNKa5qkrtZLb6cjrNi5GTF99fEZbzKTpveTV2Iqlf8sKU6y3j9HKD0uDVIdnL5NRga_M3yVP_eti9dQcPN3fdzsBV0GaVixBwVCkkLAQKaRqiAORJwkPlhZBkFFTGE4EiUb6dQppBFvpCiLZUGLAAmuSkzp3r8nWBpoon5UIX9mTMQquEMy_kljqrKaVLYzRm8VznM6nfY-rFa4exdRjXDi18vIlcJDNMt-ivMQuc1oCRI_y790_UD9tYemc</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Jansen, Jamie A.F.</creator><creator>Tosserams, Anouk</creator><creator>Weerdesteyn, Vivian G.M.</creator><creator>Bloem, Bastiaan R.</creator><creator>Nonnekes, Jorik</creator><general>SAGE Publications</general><general>IOS Press BV</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20230101</creationdate><title>The ‘Pants-Sign’: A Predictor for Falling in People with Parkinson’s Disease?</title><author>Jansen, Jamie A.F. ; Tosserams, Anouk ; Weerdesteyn, Vivian G.M. ; Bloem, Bastiaan R. ; Nonnekes, Jorik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-e385ecd3b29313dd9e73e5bb59c093bf13cf5b7e7bc6bb53df3f967774ace8283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cognitive ability</topic><topic>Gait Disorders, Neurologic - complications</topic><topic>Humans</topic><topic>Movement disorders</topic><topic>Neurodegenerative diseases</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson's disease</topic><topic>Physical Therapy Modalities</topic><topic>Postural Balance</topic><topic>Quality of Life</topic><topic>Regression analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jansen, Jamie A.F.</creatorcontrib><creatorcontrib>Tosserams, Anouk</creatorcontrib><creatorcontrib>Weerdesteyn, Vivian G.M.</creatorcontrib><creatorcontrib>Bloem, Bastiaan R.</creatorcontrib><creatorcontrib>Nonnekes, Jorik</creatorcontrib><collection>SAGE Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of Parkinson's disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jansen, Jamie A.F.</au><au>Tosserams, Anouk</au><au>Weerdesteyn, Vivian G.M.</au><au>Bloem, Bastiaan R.</au><au>Nonnekes, Jorik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The ‘Pants-Sign’: A Predictor for Falling in People with Parkinson’s Disease?</atitle><jtitle>Journal of Parkinson's disease</jtitle><addtitle>J Parkinsons Dis</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>13</volume><issue>8</issue><spage>1321</spage><epage>1327</epage><pages>1321-1327</pages><issn>1877-7171</issn><eissn>1877-718X</eissn><abstract>Background:
A history of falls is the most established predictor of future falls in people with Parkinson’s disease (PD). However, predicting a first fall remains challenging.
Objective:
To assess whether experiencing difficulties putting on pants while standing is a viable predictor of future falling, and specifically a first fall, in persons with PD. We define this ‘Pants-sign’ as people who resort to putting on their pants only while seated.
Methods:
264 persons with PD were included. Information on the Pants-sign, history of falls, disease severity (MDS-UPDRS part III), freezing of gait (N-FOGQ > 0), cognitive function (MoCA), self-reported disability (Schwab & England scale), health-related quality of life (SF-12), Timed-Up-and-Go, and one-legged stance were determined at baseline and after one-year follow-up. The association between the Pants-sign and future falling was examined by univariate logistic regression analysis. A multivariate step-wise logistic regression with forward selection was employed to identify the strongest associations in the entire cohort and a sub-cohort of people without falls in the year prior to baseline.
Results:
The Pants-sign was univariably associated with a future fall (OR = 2.406, 95% CI [1.313–4.409], p = 0.004]), but was not an independent predictor in the multivariate logistic regression; predictors were higher MDS-UPDRS part III scores (OR = 1.088, 95% CI [1.056–1.121], p < 0.001] and history of falls (OR = 5.696, 95% CI [2.650–12.243], p≤0.001]. For the sub-cohort of people without falls in the previous year (n = 189), the Pants-sign was not associated with future falls.
Conclusions:
The Pants-sign is simple to assess and is associated with future falling in PD but is not an independent predictor.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>38108362</pmid><doi>10.3233/JPD-230353</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1877-7171 |
| ispartof | Journal of Parkinson's disease, 2023-01, Vol.13 (8), p.1321-1327 |
| issn | 1877-7171 1877-718X |
| language | eng |
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| source | MEDLINE; Directory of Open Access Journals |
| subjects | Cognitive ability Gait Disorders, Neurologic - complications Humans Movement disorders Neurodegenerative diseases Parkinson Disease - complications Parkinson's disease Physical Therapy Modalities Postural Balance Quality of Life Regression analysis |
| title | The ‘Pants-Sign’: A Predictor for Falling in People with Parkinson’s Disease? |
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