Effect of F Substituents in Thiophenol on the Structure and Properties of µ2-S-(Difluorothiolate)tetranitrosyl Iron Binuclear Complexes
Two new neutral binuclear tetranitrosyl iron complexes of general formula [Fe 2 R 2 (NO) 4 ] with R = 2,4-difluorothiophenyl (complex 1 ) and 3,4-difluorothiophenyl (complex 2 ), donors of nitrogen monoxide (NO), were prepared. The complexes were characterized by single-crystal X-ray diffraction, IR...
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| Veröffentlicht in: | Russian journal of inorganic chemistry 2023-09, Vol.68 (9), p.1143-1158 |
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| creator | Sanina, N. A. Konyukhova, A. S. Korchagin, D. V. Ovanesyan, N. S. Kulikov, A. V. Mumyatova, V. A. Terent’ev, A. A. Aldoshin, S. M. |
| description | Two new neutral binuclear tetranitrosyl iron complexes of general formula [Fe
2
R
2
(NO)
4
] with R = 2,4-difluorothiophenyl (complex
1
) and 3,4-difluorothiophenyl (complex
2
), donors of nitrogen monoxide (NO), were prepared. The complexes were characterized by single-crystal X-ray diffraction, IR, Mössbauer, EPR spectroscopy, and elemental analysis. The antibacterial activity and cytotoxicity of complex
1
, complex
2
, and previously synthesized [
(NO)
4
] with R'= 2,4-dichlorothiophenyl (complex
3
) were studied for the first time. The “amount of NO–biological activity” correlations were analyzed depending on the nature and position of the substituent in the thiophenyl ligand. Complex
2
was found to have antibacterial activity that was four times as high as that of the known antibiotic kanamycin. The anti-biofilm activity of complex
2
was studied; it inhibited 46% of biofilm formation and destroyed 32% of
M. Luteus
biofilms, surpassing the effects of the reference drugs kanamycin and ampicillin. |
| doi_str_mv | 10.1134/S0036023623601526 |
| format | Article |
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2
R
2
(NO)
4
] with R = 2,4-difluorothiophenyl (complex
1
) and 3,4-difluorothiophenyl (complex
2
), donors of nitrogen monoxide (NO), were prepared. The complexes were characterized by single-crystal X-ray diffraction, IR, Mössbauer, EPR spectroscopy, and elemental analysis. The antibacterial activity and cytotoxicity of complex
1
, complex
2
, and previously synthesized [
(NO)
4
] with R'= 2,4-dichlorothiophenyl (complex
3
) were studied for the first time. The “amount of NO–biological activity” correlations were analyzed depending on the nature and position of the substituent in the thiophenyl ligand. Complex
2
was found to have antibacterial activity that was four times as high as that of the known antibiotic kanamycin. The anti-biofilm activity of complex
2
was studied; it inhibited 46% of biofilm formation and destroyed 32% of
M. Luteus
biofilms, surpassing the effects of the reference drugs kanamycin and ampicillin.</description><identifier>ISSN: 0036-0236</identifier><identifier>EISSN: 1531-8613</identifier><identifier>DOI: 10.1134/S0036023623601526</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Ampicillin ; Biofilms ; Biological activity ; Chemical analysis ; Chemistry ; Chemistry and Materials Science ; Coordination Compounds ; Infrared spectroscopy ; Inorganic Chemistry ; Iron ; Nitric oxide ; Single crystals</subject><ispartof>Russian journal of inorganic chemistry, 2023-09, Vol.68 (9), p.1143-1158</ispartof><rights>Pleiades Publishing, Ltd. 2023. ISSN 0036-0236, Russian Journal of Inorganic Chemistry, 2023, Vol. 68, No. 9, pp. 1143–1158. © Pleiades Publishing, Ltd., 2023. ISSN 0036-0236, Russian Journal of Inorganic Chemistry, 2023. © Pleiades Publishing, Ltd., 2023. Russian Text © The Author(s), 2023, published in Zhurnal Neorganicheskoi Khimii, 2023, Vol. 68, No. 9, pp. 1165–1180.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c268t-351c0cb2a6e167040600f173613274eb9d8d0a386ee1405074c8d569a1c4eeb43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S0036023623601526$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S0036023623601526$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Sanina, N. A.</creatorcontrib><creatorcontrib>Konyukhova, A. S.</creatorcontrib><creatorcontrib>Korchagin, D. V.</creatorcontrib><creatorcontrib>Ovanesyan, N. S.</creatorcontrib><creatorcontrib>Kulikov, A. V.</creatorcontrib><creatorcontrib>Mumyatova, V. A.</creatorcontrib><creatorcontrib>Terent’ev, A. A.</creatorcontrib><creatorcontrib>Aldoshin, S. M.</creatorcontrib><title>Effect of F Substituents in Thiophenol on the Structure and Properties of µ2-S-(Difluorothiolate)tetranitrosyl Iron Binuclear Complexes</title><title>Russian journal of inorganic chemistry</title><addtitle>Russ. J. Inorg. Chem</addtitle><description>Two new neutral binuclear tetranitrosyl iron complexes of general formula [Fe
2
R
2
(NO)
4
] with R = 2,4-difluorothiophenyl (complex
1
) and 3,4-difluorothiophenyl (complex
2
), donors of nitrogen monoxide (NO), were prepared. The complexes were characterized by single-crystal X-ray diffraction, IR, Mössbauer, EPR spectroscopy, and elemental analysis. The antibacterial activity and cytotoxicity of complex
1
, complex
2
, and previously synthesized [
(NO)
4
] with R'= 2,4-dichlorothiophenyl (complex
3
) were studied for the first time. The “amount of NO–biological activity” correlations were analyzed depending on the nature and position of the substituent in the thiophenyl ligand. Complex
2
was found to have antibacterial activity that was four times as high as that of the known antibiotic kanamycin. The anti-biofilm activity of complex
2
was studied; it inhibited 46% of biofilm formation and destroyed 32% of
M. Luteus
biofilms, surpassing the effects of the reference drugs kanamycin and ampicillin.</description><subject>Ampicillin</subject><subject>Biofilms</subject><subject>Biological activity</subject><subject>Chemical analysis</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Coordination Compounds</subject><subject>Infrared spectroscopy</subject><subject>Inorganic Chemistry</subject><subject>Iron</subject><subject>Nitric oxide</subject><subject>Single crystals</subject><issn>0036-0236</issn><issn>1531-8613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kM9KAzEQxoMoWP88gLeAFz2sTv5sdnvUWrVQUKielzSdtVu2yZpkQd_AF_IFfDJTKngQYWAO8_2-mfkIOWFwwZiQlzMAoYALlQpYztUOGbBcsKxUTOySwWacbeb75CCEFYCUUJQD8jGuazSRupre0lk_D7GJPdoYaGPp07Jx3RKta6mzNC6RzqLvTew9Um0X9NG7Dn1sMGz4r0-ezbKzm6Zue-ddTHCrI55HjF7bJnoX3ls68cnqurG9aVF7OnLrrsU3DEdkr9ZtwOOffkieb8dPo_ts-nA3GV1NM8NVGTORMwNmzrVCpgqQoABqVoj0JS8kzoeLcgFalAqRScihkKZc5GqomZGIcykOyenWt_PutccQq5XrvU0rKz4EnkOZqzyp2FZl0tXBY111vllr_14xqDaBV38CTwzfMiFp7Qv6X-f_oW8ZuIOF</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Sanina, N. A.</creator><creator>Konyukhova, A. S.</creator><creator>Korchagin, D. V.</creator><creator>Ovanesyan, N. S.</creator><creator>Kulikov, A. V.</creator><creator>Mumyatova, V. A.</creator><creator>Terent’ev, A. A.</creator><creator>Aldoshin, S. M.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20230901</creationdate><title>Effect of F Substituents in Thiophenol on the Structure and Properties of µ2-S-(Difluorothiolate)tetranitrosyl Iron Binuclear Complexes</title><author>Sanina, N. A. ; Konyukhova, A. S. ; Korchagin, D. V. ; Ovanesyan, N. S. ; Kulikov, A. V. ; Mumyatova, V. A. ; Terent’ev, A. A. ; Aldoshin, S. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c268t-351c0cb2a6e167040600f173613274eb9d8d0a386ee1405074c8d569a1c4eeb43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Ampicillin</topic><topic>Biofilms</topic><topic>Biological activity</topic><topic>Chemical analysis</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Coordination Compounds</topic><topic>Infrared spectroscopy</topic><topic>Inorganic Chemistry</topic><topic>Iron</topic><topic>Nitric oxide</topic><topic>Single crystals</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sanina, N. A.</creatorcontrib><creatorcontrib>Konyukhova, A. S.</creatorcontrib><creatorcontrib>Korchagin, D. V.</creatorcontrib><creatorcontrib>Ovanesyan, N. S.</creatorcontrib><creatorcontrib>Kulikov, A. V.</creatorcontrib><creatorcontrib>Mumyatova, V. A.</creatorcontrib><creatorcontrib>Terent’ev, A. A.</creatorcontrib><creatorcontrib>Aldoshin, S. M.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian journal of inorganic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sanina, N. A.</au><au>Konyukhova, A. S.</au><au>Korchagin, D. V.</au><au>Ovanesyan, N. S.</au><au>Kulikov, A. V.</au><au>Mumyatova, V. A.</au><au>Terent’ev, A. A.</au><au>Aldoshin, S. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of F Substituents in Thiophenol on the Structure and Properties of µ2-S-(Difluorothiolate)tetranitrosyl Iron Binuclear Complexes</atitle><jtitle>Russian journal of inorganic chemistry</jtitle><stitle>Russ. J. Inorg. Chem</stitle><date>2023-09-01</date><risdate>2023</risdate><volume>68</volume><issue>9</issue><spage>1143</spage><epage>1158</epage><pages>1143-1158</pages><issn>0036-0236</issn><eissn>1531-8613</eissn><abstract>Two new neutral binuclear tetranitrosyl iron complexes of general formula [Fe
2
R
2
(NO)
4
] with R = 2,4-difluorothiophenyl (complex
1
) and 3,4-difluorothiophenyl (complex
2
), donors of nitrogen monoxide (NO), were prepared. The complexes were characterized by single-crystal X-ray diffraction, IR, Mössbauer, EPR spectroscopy, and elemental analysis. The antibacterial activity and cytotoxicity of complex
1
, complex
2
, and previously synthesized [
(NO)
4
] with R'= 2,4-dichlorothiophenyl (complex
3
) were studied for the first time. The “amount of NO–biological activity” correlations were analyzed depending on the nature and position of the substituent in the thiophenyl ligand. Complex
2
was found to have antibacterial activity that was four times as high as that of the known antibiotic kanamycin. The anti-biofilm activity of complex
2
was studied; it inhibited 46% of biofilm formation and destroyed 32% of
M. Luteus
biofilms, surpassing the effects of the reference drugs kanamycin and ampicillin.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S0036023623601526</doi><tpages>16</tpages></addata></record> |
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| language | eng |
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| source | Springer Online Journals Complete |
| subjects | Ampicillin Biofilms Biological activity Chemical analysis Chemistry Chemistry and Materials Science Coordination Compounds Infrared spectroscopy Inorganic Chemistry Iron Nitric oxide Single crystals |
| title | Effect of F Substituents in Thiophenol on the Structure and Properties of µ2-S-(Difluorothiolate)tetranitrosyl Iron Binuclear Complexes |
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