A new triazolyl‐indolo‐quinoxaline induces apoptosis in gastric cancer cells by abrogating the STAT3/5 pathway through upregulation of PTPεC

Signal transducer and activator of transcription 3 (STAT3) and STAT5 are the transcription factors that have been studied extensively in relevance to the development of cancers in humans. Suppression of either STAT3 or STAT5‐mediated signaling events has been demonstrated to be effective in inducing...

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Veröffentlicht in:	Drug development research 2023-12, Vol.84 (8), p.1724-1738
Hauptverfasser:	Suresh, Rajaghatta N., Jung, Young Y., Mohan, Chakrabhavi D., Gowda, Shalini V., Harsha, Kachigere B., Mantelingu, Kempegowda, Sethi, Gautam, Ahn, Kwang S., Rangappa, Kanchugarakoppal S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Assaying Cancer Caspase Cytotoxicity DNA nucleotidylexotransferase DNA-Binding Proteins - metabolism Electrophoretic mobility Flow cytometry Fluorescein isothiocyanate Gastric cancer Gene expression Humans Hybrids Immunofluorescence Janus kinase Janus kinase 2 Janus Kinases - metabolism Janus Kinases - pharmacology Kinases nonreceptor tyrosine kinase Pervanadate Phosphorylation Protein-tyrosine-phosphatase Proteins proteins tyrosine phosphatase Quinoxaline Quinoxalines Quinoxalines - pharmacology Signal Transduction STAT Transcription Factors - metabolism STAT Transcription Factors - pharmacology Stat3 protein STAT3 Transcription Factor - metabolism Stat5 protein STAT5 Transcription Factor - metabolism STAT5 Transcription Factor - pharmacology Stomach Neoplasms Synthesis Toxicity Trans-Activators Transcription factors Tyrosine Up-Regulation
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