Nanotechnology in drug delivery system: current status and future perspective

Nanotechnology is a technology for nanoparticles made from synthetic or natural polymers. In recent years, nanotechnology has become a popular term for the major efforts of science and technology today. Nanotechnology is unique because it encompasses a wide variety of disciplines, from basic materials sciences to personal care applications.But prior to their application, considerablechallenges related to clinical toxicities should be taken into account.Nanotechnology hasfinally and firmly emerged as the realm of drug delivery. The performance of intelligent drugdelivery systems is continuously improved with the purpose of maximizing therapeutic activityand minimizing undesirable side effects. Recent advances in material design and theemergence of new therapeutics are contributing to the development of more sophisticatedsystems. This review provides an overview on the relation between nanotechnology and drug delivery, various nano based drug delivery systems being commercialized and undergoing, recent advances in various nano based drug delivery systems, principal challenges both from a manufacturing and regulatory perspective and safety issues in nano-based drug delivery systems.