Evaluation of Human Epididymis Protein 4 Tumor Marker Level in the First Half of Pregnancy

This study aims to understand the related factors and their effects on the HE4 Tumor markers and assess their values during pregnancy. In this cross-sectional study, 90 pregnant women referred to receive routine care in the first half of gestation were included. Demographic information was collected. The levels of the HE4 tumor marker in the mothers’ blood samples were checked, and the results were recorded.The average level of HE4 was 41.27±14.13 picomoles per liter, which was in the normal range of non-pregnant women in all subjects (less than 140). HE4 levels were not correlated with age, gestational age, gravida, and body mass index (P.value < 0.05). The mean HE4 in the abortion group was higher than the non-abortion group, which showed a statistically significant difference (P = 0.001).According to the results of this study, pregnancy has no significant impact on this marker. Hence, it can be used as a tumor marker to evaluate adnexal masses during pregnancy