FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters

The heterogeneity of cancer stem cells (CSCs) within tumors presents a challenge in therapeutic targeting. To decipher the cellular plasticity that fuels phenotypic heterogeneity, we undertook single-cell transcriptomics analysis in triple-negative breast cancer (TNBC) to identify subpopulations in...

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Veröffentlicht in:	The Journal of clinical investigation 2023-11, Vol.133 (22), p.1-18
Hauptverfasser:	Li, Mengjiao, Nishimura, Tatsunori, Takeuchi, Yasuto, Hongu, Tsunaki, Wang, Yuming, Shiokawa, Daisuke, Wang, Kang, Hirose, Haruka, Sasahara, Asako, Yano, Masao, Ishikawa, Satoko, Inokuchi, Masafumi, Ota, Tetsuo, Tanabe, Masahiko, Tada, Kei-ichiro, Akiyama, Tetsu, Cheng, Xi, Liu, Chia-Chi, Yamashita, Toshinari, Sugano, Sumio, Uchida, Yutaro, Chiba, Tomoki, Asahara, Hiroshi, Nakagawa, Masahiro, Sato, Shinya, Miyagi, Yohei, Shimamura, Teppei, Nagai, Luis Augusto, Kanal, Akinori, Katoh, Manami, Nomura, Seitaro, Nakato, Ryuichiro, Suzuki, Yutaka, Tojo, Arinobu, Voon, Dominic C, Ogawa, Seishi, Okamoto, Koji, Foukakis, Theodoros, Gotoh, Noriko
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Biomedical research Breast cancer Cardiac glycosides Chemoresistance Chemotherapy Drug resistance Genomics Glycosides Kinases Medical prognosis Na+/K+-exchanging ATPase Patients Phenotypic plasticity Pregnancy Stem cells Therapeutic targets Transcriptomics Tumors
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