Fibroin reinforced, strontium-doped calcium phosphate silicate cements for bone tissue engineering applications
Calcium phosphate silicate cements (CPSCs) have been developed to overcome problems like high acidity due to presence of brushite and high temperatures evolving as polymethyl methacrylate (PMMA) cements cure at surgery site. However, CPSCs with good handling and injectability have not been successfu...
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| Veröffentlicht in: | Journal of materials research 2023-12, Vol.38 (23), p.5017-5031 |
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| creator | Işık, Gülhan Pazarçeviren, Ahmet Engin Evis, Zafer Tezcaner, Ayşen |
| description | Calcium phosphate silicate cements (CPSCs) have been developed to overcome problems like high acidity due to presence of brushite and high temperatures evolving as polymethyl methacrylate (PMMA) cements cure at surgery site. However, CPSCs with good handling and injectability have not been successfully produced. Here, we aimed to develop a biocompatible and osteoconductive bone cement composed of strontium (Sr)-doped tri-calcium silicates (C
3
S), monocalcium monophosphate and silk fibroin (SF). C
3
S powders were mixed with monocalcium monophosphate, and SF to obtain injectable CPSC. Physical, mechanical and biological characterization studies revealed that SF presence minimized alkalinity, increased rate of weight loss, porosity and elasticity but decreased maximum yield strength. The i
n vitro
cell culture studies showed that all CPSCs were biocompatible. CPSC-Sr2-2% SF group performed the best in terms of osteogenic differentiation. These results suggest that CPSCs hold promise as bone cement however, in vivo studies should be conducted.
Graphical abstract |
| doi_str_mv | 10.1557/s43578-023-01211-6 |
| format | Article |
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3
S), monocalcium monophosphate and silk fibroin (SF). C
3
S powders were mixed with monocalcium monophosphate, and SF to obtain injectable CPSC. Physical, mechanical and biological characterization studies revealed that SF presence minimized alkalinity, increased rate of weight loss, porosity and elasticity but decreased maximum yield strength. The i
n vitro
cell culture studies showed that all CPSCs were biocompatible. CPSC-Sr2-2% SF group performed the best in terms of osteogenic differentiation. These results suggest that CPSCs hold promise as bone cement however, in vivo studies should be conducted.
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3
S), monocalcium monophosphate and silk fibroin (SF). C
3
S powders were mixed with monocalcium monophosphate, and SF to obtain injectable CPSC. Physical, mechanical and biological characterization studies revealed that SF presence minimized alkalinity, increased rate of weight loss, porosity and elasticity but decreased maximum yield strength. The i
n vitro
cell culture studies showed that all CPSCs were biocompatible. CPSC-Sr2-2% SF group performed the best in terms of osteogenic differentiation. These results suggest that CPSCs hold promise as bone cement however, in vivo studies should be conducted.
Graphical abstract</description><subject>Alkalinity</subject><subject>Applied and Technical Physics</subject><subject>Biocompatibility</subject><subject>Biomaterials</subject><subject>Bone cements</subject><subject>Calcium phosphates</subject><subject>Calcium silicates</subject><subject>Chemistry and Materials Science</subject><subject>Differentiation (biology)</subject><subject>High temperature</subject><subject>In vivo methods and tests</subject><subject>Injectability</subject><subject>Inorganic Chemistry</subject><subject>Materials Engineering</subject><subject>Materials research</subject><subject>Materials Science</subject><subject>Mechanical properties</subject><subject>Nanotechnology</subject><subject>Polymethyl methacrylate</subject><subject>Silicates</subject><subject>Silk fibroin</subject><subject>Tissue engineering</subject><subject>Tricalcium silicate</subject><subject>Weight loss</subject><issn>0884-2914</issn><issn>2044-5326</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kEFLAzEQhYMoWKt_wFPAq9FJNtlkj1KsCgUveg7b7KRNaZM12R78925bwZunmWHee8N8hNxyeOBK6cciK6UNA1Ex4IJzVp-RiQApmapEfU4mYIxkouHyklyVsgHgCrSckDQPy5xCpBlD9Ck77O5pGXKKQ9jvWJd67Khrt26caL9OpV-3A9IStsEdGoc7jEOho5UuU0Q6hFL2SDGuQkTMIa5o2_dHdUixXJML324L3vzWKfmcP3_MXtni_eVt9rRgTmgYGKpOddpV6DgH1TSdgKUfixfaKCFkDahaDyBx3CoDvvGNbhU439SmrXU1JXen3D6nrz2WwW7SPsfxpBWmMbIWWphRJU4ql1MpGb3tc9i1-dtysAew9gTWjmDtEaytR1N1MpX-8B7mv-h_XD9Wc31e</recordid><startdate>20231214</startdate><enddate>20231214</enddate><creator>Işık, Gülhan</creator><creator>Pazarçeviren, Ahmet Engin</creator><creator>Evis, Zafer</creator><creator>Tezcaner, Ayşen</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0002-2327-8916</orcidid><orcidid>https://orcid.org/0000-0003-4292-5856</orcidid><orcidid>https://orcid.org/0000-0002-7518-8162</orcidid><orcidid>https://orcid.org/0000-0001-5233-860X</orcidid></search><sort><creationdate>20231214</creationdate><title>Fibroin reinforced, strontium-doped calcium phosphate silicate cements for bone tissue engineering applications</title><author>Işık, Gülhan ; Pazarçeviren, Ahmet Engin ; Evis, Zafer ; Tezcaner, Ayşen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c270t-e5d5d7c3ec110599d20bf99df278522460e5af004e059580f9f97a50cf968a673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alkalinity</topic><topic>Applied and Technical Physics</topic><topic>Biocompatibility</topic><topic>Biomaterials</topic><topic>Bone cements</topic><topic>Calcium phosphates</topic><topic>Calcium silicates</topic><topic>Chemistry and Materials Science</topic><topic>Differentiation (biology)</topic><topic>High temperature</topic><topic>In vivo methods and tests</topic><topic>Injectability</topic><topic>Inorganic Chemistry</topic><topic>Materials Engineering</topic><topic>Materials research</topic><topic>Materials Science</topic><topic>Mechanical properties</topic><topic>Nanotechnology</topic><topic>Polymethyl methacrylate</topic><topic>Silicates</topic><topic>Silk fibroin</topic><topic>Tissue engineering</topic><topic>Tricalcium silicate</topic><topic>Weight loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Işık, Gülhan</creatorcontrib><creatorcontrib>Pazarçeviren, Ahmet Engin</creatorcontrib><creatorcontrib>Evis, Zafer</creatorcontrib><creatorcontrib>Tezcaner, Ayşen</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of materials research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Işık, Gülhan</au><au>Pazarçeviren, Ahmet Engin</au><au>Evis, Zafer</au><au>Tezcaner, Ayşen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fibroin reinforced, strontium-doped calcium phosphate silicate cements for bone tissue engineering applications</atitle><jtitle>Journal of materials research</jtitle><stitle>Journal of Materials Research</stitle><date>2023-12-14</date><risdate>2023</risdate><volume>38</volume><issue>23</issue><spage>5017</spage><epage>5031</epage><pages>5017-5031</pages><issn>0884-2914</issn><eissn>2044-5326</eissn><abstract>Calcium phosphate silicate cements (CPSCs) have been developed to overcome problems like high acidity due to presence of brushite and high temperatures evolving as polymethyl methacrylate (PMMA) cements cure at surgery site. However, CPSCs with good handling and injectability have not been successfully produced. Here, we aimed to develop a biocompatible and osteoconductive bone cement composed of strontium (Sr)-doped tri-calcium silicates (C
3
S), monocalcium monophosphate and silk fibroin (SF). C
3
S powders were mixed with monocalcium monophosphate, and SF to obtain injectable CPSC. Physical, mechanical and biological characterization studies revealed that SF presence minimized alkalinity, increased rate of weight loss, porosity and elasticity but decreased maximum yield strength. The i
n vitro
cell culture studies showed that all CPSCs were biocompatible. CPSC-Sr2-2% SF group performed the best in terms of osteogenic differentiation. These results suggest that CPSCs hold promise as bone cement however, in vivo studies should be conducted.
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| subjects | Alkalinity Applied and Technical Physics Biocompatibility Biomaterials Bone cements Calcium phosphates Calcium silicates Chemistry and Materials Science Differentiation (biology) High temperature In vivo methods and tests Injectability Inorganic Chemistry Materials Engineering Materials research Materials Science Mechanical properties Nanotechnology Polymethyl methacrylate Silicates Silk fibroin Tissue engineering Tricalcium silicate Weight loss |
| title | Fibroin reinforced, strontium-doped calcium phosphate silicate cements for bone tissue engineering applications |
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