Hepatoprotective effect of ferulic acid and/or low doses of γ-irradiation against cisplatin-induced liver injury in rats

The therapeutic efficacy of cisplatin (CIS) is limited owing to its hepatotoxic side effects. The current study aimed to investigate the protective impact of ferulic acid (FA) and low-doses of γ-irradiation (LDR) against CIS-prompted hepatotoxicity in rats. Adult male Swiss albino rats were divided...

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Veröffentlicht in:	Human & experimental toxicology 2022-10, Vol.41, p.9603271221136205
Hauptverfasser:	Esmat, Marwa A, Osman, Ahmed, Hassan, Rasha E, Hagag, Sanaa A, El-maghraby, Tarek K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - metabolism Antioxidants - pharmacology Antioxidants - therapeutic use Apoptosis Caspase 3 - genetics Caspase 3 - metabolism Caspase-1 Caspase-3 Chemical and Drug Induced Liver Injury - drug therapy Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - prevention & control Chemical and Drug Induced Liver Injury, Chronic - drug therapy Cisplatin Cisplatin - toxicity Cyclooxygenase 2 - metabolism Enzymatic activity Enzyme activity Ferulic acid Free radicals Gamma irradiation Hepatotoxicity IL-1β Immunohistochemistry Inflammation Injury prevention Irradiation Lipid peroxidation Lipids Liver Male Oxidative Stress Peroxidation Rats Side effects Superoxide Dismutase - metabolism Tissues Transaminases Transaminases - metabolism Transaminases - pharmacology γ Radiation
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