Solid solution polymorphs afford two highly soluble co-drug forms of tolbutamide and chlorpropamide

The search for solid solutions of class-two insulin secretagogues, tolbutamide and chlorpropamide, reveals a rare case of monotropic polymorphism for the mixed crystals. At any stoichiometry, two crystal forms are isolated that are kinetically stable at room temperature from a few months to over a y...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2023-11, Vol.59 (96), p.14321-14324
Hauptverfasser:	Spoletti, Enrico, Verma, Vivek, Cappuccino, Chiara, Lusi, Matteo
Format:	Artikel
Sprache:	eng
Schlagworte:	Mixed crystals Polymorphism Room temperature Solid solutions Stoichiometry
Online-Zugang:	Volltext
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