Evaluation of Vitamin D Levels in Course of Acute Rheumatic Fever with Active Carditis
Objective: Vitamin D is a hormone with immunomodulatory and anti-inflammatory effects besides calcium hemostasis. The present study aims to evaluate the relationship between acute rheumatic fever (ARF) attacks and vitamin D levels. Materials and Methods: Acute phase reactants, vitamin D levels and e...
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| Veröffentlicht in: | Erciyes Medical Journal 2020-09, Vol.42 (3), p.312-316 |
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| description | Objective: Vitamin D is a hormone with immunomodulatory and anti-inflammatory effects besides calcium hemostasis. The present study aims to evaluate the relationship between acute rheumatic fever (ARF) attacks and vitamin D levels. Materials and Methods: Acute phase reactants, vitamin D levels and echocardiographic parameters of 25 patients with active carditis were evaluated at the time of the acute attack and in 1, 2 and 6 months of follow-up and compared to a control group of 25 age-and sex-matched healthy children. Results: At the time of diagnosis, WBC, ESR and CRP levels were significantly higher (p |
| doi_str_mv | 10.14744/etd.2020.26429 |
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The present study aims to evaluate the relationship between acute rheumatic fever (ARF) attacks and vitamin D levels. Materials and Methods: Acute phase reactants, vitamin D levels and echocardiographic parameters of 25 patients with active carditis were evaluated at the time of the acute attack and in 1, 2 and 6 months of follow-up and compared to a control group of 25 age-and sex-matched healthy children. Results: At the time of diagnosis, WBC, ESR and CRP levels were significantly higher (p<0.05), and vitamin D levels were lower than the control group, not statistically significant (p=0.07). The mean vitamin D levels of the patients diagnosed in winter and spring-autumn seasons were 17.54+-9.89 μg/L, and the rate of vitamin D deficiency was 47.3%. The mean vitamin D levels of the control group, in the same seasons, were 23.97+-9.48 μg/L and the vitamin D deficiency rate was 19.1%. The vitamin D levels at the time of diagnosis of the ARF group were lower than the control group (p=0.038) and the attributed risk for vitamin D deficiency in ARF carditis in winter and spring seasons was found 3.46 (95% CI 1.1–5.14). Furthermore, cardiac parameters were significantly getting better, while vitamin D deficiency rates decreasing during the follow-up period. Conclusion: ARF attacks were found to be more frequent in non-summer seasons when vitamin D levels were lower. Echocardiographic and laboratory parameters improved with increasing vitamin D levels. These findings suggest that anti-inflammatory and immunomodulatory effects of vitamin D.</description><identifier>ISSN: 2149-2247</identifier><identifier>EISSN: 2980-2156</identifier><identifier>EISSN: 2149-2247</identifier><identifier>DOI: 10.14744/etd.2020.26429</identifier><language>eng</language><publisher>Istanbul: Kare Publishing</publisher><subject>carditis ; rheumatic fever ; vitamin d</subject><ispartof>Erciyes Medical Journal, 2020-09, Vol.42 (3), p.312-316</ispartof><rights>2020. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2894762277?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,778,782,862,21371,21372,27907,27908,33513,33727,43642,43788,64366,64370,72220</link.rule.ids></links><search><creatorcontrib>Türkuçar, Serkan</creatorcontrib><title>Evaluation of Vitamin D Levels in Course of Acute Rheumatic Fever with Active Carditis</title><title>Erciyes Medical Journal</title><description>Objective: Vitamin D is a hormone with immunomodulatory and anti-inflammatory effects besides calcium hemostasis. The present study aims to evaluate the relationship between acute rheumatic fever (ARF) attacks and vitamin D levels. Materials and Methods: Acute phase reactants, vitamin D levels and echocardiographic parameters of 25 patients with active carditis were evaluated at the time of the acute attack and in 1, 2 and 6 months of follow-up and compared to a control group of 25 age-and sex-matched healthy children. Results: At the time of diagnosis, WBC, ESR and CRP levels were significantly higher (p<0.05), and vitamin D levels were lower than the control group, not statistically significant (p=0.07). The mean vitamin D levels of the patients diagnosed in winter and spring-autumn seasons were 17.54+-9.89 μg/L, and the rate of vitamin D deficiency was 47.3%. The mean vitamin D levels of the control group, in the same seasons, were 23.97+-9.48 μg/L and the vitamin D deficiency rate was 19.1%. The vitamin D levels at the time of diagnosis of the ARF group were lower than the control group (p=0.038) and the attributed risk for vitamin D deficiency in ARF carditis in winter and spring seasons was found 3.46 (95% CI 1.1–5.14). Furthermore, cardiac parameters were significantly getting better, while vitamin D deficiency rates decreasing during the follow-up period. Conclusion: ARF attacks were found to be more frequent in non-summer seasons when vitamin D levels were lower. Echocardiographic and laboratory parameters improved with increasing vitamin D levels. These findings suggest that anti-inflammatory and immunomodulatory effects of vitamin D.</description><subject>carditis</subject><subject>rheumatic fever</subject><subject>vitamin d</subject><issn>2149-2247</issn><issn>2980-2156</issn><issn>2149-2247</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNo9UU1LAzEQXURB0Z69BjxvTSbfR6mfUBBEvYZ0d6KRtqtJtuK_N23F0wzz3rx5w2uac0anTGghLrH0U6BAp6AE2IPmBKyhLTCpDmvPhG0BhD5uJjnHBZVUcwaKnzSvNxu_HH2Jw5oMgbzG4ldxTa7JHDe4zKT2s2FMGbfoVTcWJE_vOK7qRkduKyeR71jeK1TiBsnMpz6WmM-ao-CXGSd_9bR5ub15nt2388e7h9nVvO046NJywIXv-04KqQQD5MIsQDDUxgbDqPZSGSl8YIpZI0AEWOhgDAUrFVBP-WnzsNftB__hPlNc-fTjBh_dbjCkN-dTtbpEFzopObXCBt4Jitwg6K7XGhn0RgVftS72Wp9p-BoxF_dRP19X-w6MFVoBaF1Zl3tWl4acE4b_q4y6XRauZuG2WbhdFvwXzcl57Q</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Türkuçar, Serkan</creator><general>Kare Publishing</general><general>KARE Publishing</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>DOA</scope></search><sort><creationdate>20200901</creationdate><title>Evaluation of Vitamin D Levels in Course of Acute Rheumatic Fever with Active Carditis</title><author>Türkuçar, Serkan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-32ebaddc5456412e348b241e789f8107a56854af16198424f2b7f880295620a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>carditis</topic><topic>rheumatic fever</topic><topic>vitamin d</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Türkuçar, Serkan</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Erciyes Medical Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Türkuçar, Serkan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Vitamin D Levels in Course of Acute Rheumatic Fever with Active Carditis</atitle><jtitle>Erciyes Medical Journal</jtitle><date>2020-09-01</date><risdate>2020</risdate><volume>42</volume><issue>3</issue><spage>312</spage><epage>316</epage><pages>312-316</pages><issn>2149-2247</issn><eissn>2980-2156</eissn><eissn>2149-2247</eissn><abstract>Objective: Vitamin D is a hormone with immunomodulatory and anti-inflammatory effects besides calcium hemostasis. The present study aims to evaluate the relationship between acute rheumatic fever (ARF) attacks and vitamin D levels. Materials and Methods: Acute phase reactants, vitamin D levels and echocardiographic parameters of 25 patients with active carditis were evaluated at the time of the acute attack and in 1, 2 and 6 months of follow-up and compared to a control group of 25 age-and sex-matched healthy children. Results: At the time of diagnosis, WBC, ESR and CRP levels were significantly higher (p<0.05), and vitamin D levels were lower than the control group, not statistically significant (p=0.07). The mean vitamin D levels of the patients diagnosed in winter and spring-autumn seasons were 17.54+-9.89 μg/L, and the rate of vitamin D deficiency was 47.3%. The mean vitamin D levels of the control group, in the same seasons, were 23.97+-9.48 μg/L and the vitamin D deficiency rate was 19.1%. The vitamin D levels at the time of diagnosis of the ARF group were lower than the control group (p=0.038) and the attributed risk for vitamin D deficiency in ARF carditis in winter and spring seasons was found 3.46 (95% CI 1.1–5.14). Furthermore, cardiac parameters were significantly getting better, while vitamin D deficiency rates decreasing during the follow-up period. Conclusion: ARF attacks were found to be more frequent in non-summer seasons when vitamin D levels were lower. Echocardiographic and laboratory parameters improved with increasing vitamin D levels. These findings suggest that anti-inflammatory and immunomodulatory effects of vitamin D.</abstract><cop>Istanbul</cop><pub>Kare Publishing</pub><doi>10.14744/etd.2020.26429</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | carditis rheumatic fever vitamin d |
| title | Evaluation of Vitamin D Levels in Course of Acute Rheumatic Fever with Active Carditis |
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