The Efficacy of Continuous Venovenous Hemodiafiltration with Cytokine Filter on Sepsis
Objective: Continuous renal replacement therapy is made with high biocompatibility membranes that have high current power by using diffusion and convection together or separately. The aim of the present study was to compare the EMIC-2 and AV600S filters used for continuous venovenous hemodiafiltrati...
Gespeichert in:
| Veröffentlicht in: | Erciyes Medical Journal 2020-03, Vol.42 (1), p.54-59 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 59 |
|---|---|
| container_issue | 1 |
| container_start_page | 54 |
| container_title | Erciyes Medical Journal |
| container_volume | 42 |
| creator | Avcı, Onur |
| description | Objective: Continuous renal replacement therapy is made with high biocompatibility membranes that have high current power by using diffusion and convection together or separately. The aim of the present study was to compare the EMIC-2 and AV600S filters used for continuous venovenous hemodiafiltration (CVVHDF) with respect to the effects on sepsis, the elimination of toxins that are elevated due to acute renal injury, and the effects on inflammatory mediators in severe sepsis. Materials and Methods: The study included 38 patients who were diagnosed with severe sepsis and were treated with hemodiafiltration in the intensive care unit. Acute Physiology and Chronic Health Evaluation—2 (APACHE-2) and Sequential Organ Failure Assessment (SOFA) scores of the patients were calculated before CVVHDF starts. Hematocrit (Hct), white blood cell, blood pressure, heart rate, and body temperature values were measured and recorded. Procalcitonin (PCT), tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, and IL-1 values on blood were also recorded before the process and at 8, 16, and 24 h of the process. Results: When the AV600S filtered and EMIC-2 filtered groups are compared, TNF-α values are low in the EMIC-2 filtered group (p |
| doi_str_mv | 10.14744/etd.2019.22599 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_proquest_journals_2894758863</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_df9767fdf5c84adcba488c83a92e367f</doaj_id><sourcerecordid>2894758863</sourcerecordid><originalsourceid>FETCH-LOGICAL-c327t-d3a19856f1bc0dbaedf9007bd6849f284b6479ce641f29303087a55f97b5ef1e3</originalsourceid><addsrcrecordid>eNo9UU1PAjEU3BhNJMjZ6yaeF_u5bY-GgJCQeBC5Nt1-SBG22BYN_94KxsPLm8xM5r1kquoegjEkjJBHm80YASjGCFEhrqoBEhw0CNL2umBIRIMQYbfVKCXfAQoYhqjFg2q92th66pzXSp_q4OpJ6LPvj-GY6rXtw1eZAud2H4xXzu9yVNmHvv72eVNPTjl8-N7WsyLYWBf-1R6ST3fVjVO7ZEd_e1i9zaarybxZvjwvJk_LRmPEcmOwgoLT1sFOA9Mpa5wAgHWm5UQ4xEnXEia0bQl0SGCAAWeKUidYR62DFg-rxSXXBLWVh-j3Kp5kUF6eiRDfpYrZ652VJZq1zBlHNSfK6E4RzjXHSiCLi1CyHi5Zhxg-jzZluQ3H2Jf3JeKCMMp5i4vr8eLSMaQUrfu_CoE8dyFLF_K3C3nuAv8A4aR9cA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2894758863</pqid></control><display><type>article</type><title>The Efficacy of Continuous Venovenous Hemodiafiltration with Cytokine Filter on Sepsis</title><source>DOAJ Directory of Open Access Journals</source><source>ProQuest Central</source><creator>Avcı, Onur</creator><creatorcontrib>Avcı, Onur</creatorcontrib><description>Objective: Continuous renal replacement therapy is made with high biocompatibility membranes that have high current power by using diffusion and convection together or separately. The aim of the present study was to compare the EMIC-2 and AV600S filters used for continuous venovenous hemodiafiltration (CVVHDF) with respect to the effects on sepsis, the elimination of toxins that are elevated due to acute renal injury, and the effects on inflammatory mediators in severe sepsis. Materials and Methods: The study included 38 patients who were diagnosed with severe sepsis and were treated with hemodiafiltration in the intensive care unit. Acute Physiology and Chronic Health Evaluation—2 (APACHE-2) and Sequential Organ Failure Assessment (SOFA) scores of the patients were calculated before CVVHDF starts. Hematocrit (Hct), white blood cell, blood pressure, heart rate, and body temperature values were measured and recorded. Procalcitonin (PCT), tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, and IL-1 values on blood were also recorded before the process and at 8, 16, and 24 h of the process. Results: When the AV600S filtered and EMIC-2 filtered groups are compared, TNF-α values are low in the EMIC-2 filtered group (p<0.05). There is no significant difference between the groups with respect to the measurements about APACHE-2, SOFA, IL-1β, IL-6, PCT, Hct, body temperature, mean blood pressures, and heart rate. Conclusion: We think that the filters do not cause a significant change on the elimination of inflammatory cytokines, except TNF-α, on limited numbers of patients who have sepsis with acute renal injury undergoing CVVHDF with EMIC-2 and AV600S.</description><identifier>ISSN: 2149-2247</identifier><identifier>EISSN: 2980-2156</identifier><identifier>EISSN: 2149-2247</identifier><identifier>DOI: 10.14744/etd.2019.22599</identifier><language>eng</language><publisher>Istanbul: Kare Publishing</publisher><subject>acute kidney injury ; continuous venovenous hemodiafiltration ; inflammatory cytokine ; sepsis</subject><ispartof>Erciyes Medical Journal, 2020-03, Vol.42 (1), p.54-59</ispartof><rights>2020. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2894758863?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,860,21367,27901,27902,33721,43781</link.rule.ids></links><search><creatorcontrib>Avcı, Onur</creatorcontrib><title>The Efficacy of Continuous Venovenous Hemodiafiltration with Cytokine Filter on Sepsis</title><title>Erciyes Medical Journal</title><description>Objective: Continuous renal replacement therapy is made with high biocompatibility membranes that have high current power by using diffusion and convection together or separately. The aim of the present study was to compare the EMIC-2 and AV600S filters used for continuous venovenous hemodiafiltration (CVVHDF) with respect to the effects on sepsis, the elimination of toxins that are elevated due to acute renal injury, and the effects on inflammatory mediators in severe sepsis. Materials and Methods: The study included 38 patients who were diagnosed with severe sepsis and were treated with hemodiafiltration in the intensive care unit. Acute Physiology and Chronic Health Evaluation—2 (APACHE-2) and Sequential Organ Failure Assessment (SOFA) scores of the patients were calculated before CVVHDF starts. Hematocrit (Hct), white blood cell, blood pressure, heart rate, and body temperature values were measured and recorded. Procalcitonin (PCT), tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, and IL-1 values on blood were also recorded before the process and at 8, 16, and 24 h of the process. Results: When the AV600S filtered and EMIC-2 filtered groups are compared, TNF-α values are low in the EMIC-2 filtered group (p<0.05). There is no significant difference between the groups with respect to the measurements about APACHE-2, SOFA, IL-1β, IL-6, PCT, Hct, body temperature, mean blood pressures, and heart rate. Conclusion: We think that the filters do not cause a significant change on the elimination of inflammatory cytokines, except TNF-α, on limited numbers of patients who have sepsis with acute renal injury undergoing CVVHDF with EMIC-2 and AV600S.</description><subject>acute kidney injury</subject><subject>continuous venovenous hemodiafiltration</subject><subject>inflammatory cytokine</subject><subject>sepsis</subject><issn>2149-2247</issn><issn>2980-2156</issn><issn>2149-2247</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNo9UU1PAjEU3BhNJMjZ6yaeF_u5bY-GgJCQeBC5Nt1-SBG22BYN_94KxsPLm8xM5r1kquoegjEkjJBHm80YASjGCFEhrqoBEhw0CNL2umBIRIMQYbfVKCXfAQoYhqjFg2q92th66pzXSp_q4OpJ6LPvj-GY6rXtw1eZAud2H4xXzu9yVNmHvv72eVNPTjl8-N7WsyLYWBf-1R6ST3fVjVO7ZEd_e1i9zaarybxZvjwvJk_LRmPEcmOwgoLT1sFOA9Mpa5wAgHWm5UQ4xEnXEia0bQl0SGCAAWeKUidYR62DFg-rxSXXBLWVh-j3Kp5kUF6eiRDfpYrZ652VJZq1zBlHNSfK6E4RzjXHSiCLi1CyHi5Zhxg-jzZluQ3H2Jf3JeKCMMp5i4vr8eLSMaQUrfu_CoE8dyFLF_K3C3nuAv8A4aR9cA</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Avcı, Onur</creator><general>Kare Publishing</general><general>KARE Publishing</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>DOA</scope></search><sort><creationdate>20200301</creationdate><title>The Efficacy of Continuous Venovenous Hemodiafiltration with Cytokine Filter on Sepsis</title><author>Avcı, Onur</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-d3a19856f1bc0dbaedf9007bd6849f284b6479ce641f29303087a55f97b5ef1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>acute kidney injury</topic><topic>continuous venovenous hemodiafiltration</topic><topic>inflammatory cytokine</topic><topic>sepsis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Avcı, Onur</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Erciyes Medical Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Avcı, Onur</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Efficacy of Continuous Venovenous Hemodiafiltration with Cytokine Filter on Sepsis</atitle><jtitle>Erciyes Medical Journal</jtitle><date>2020-03-01</date><risdate>2020</risdate><volume>42</volume><issue>1</issue><spage>54</spage><epage>59</epage><pages>54-59</pages><issn>2149-2247</issn><eissn>2980-2156</eissn><eissn>2149-2247</eissn><abstract>Objective: Continuous renal replacement therapy is made with high biocompatibility membranes that have high current power by using diffusion and convection together or separately. The aim of the present study was to compare the EMIC-2 and AV600S filters used for continuous venovenous hemodiafiltration (CVVHDF) with respect to the effects on sepsis, the elimination of toxins that are elevated due to acute renal injury, and the effects on inflammatory mediators in severe sepsis. Materials and Methods: The study included 38 patients who were diagnosed with severe sepsis and were treated with hemodiafiltration in the intensive care unit. Acute Physiology and Chronic Health Evaluation—2 (APACHE-2) and Sequential Organ Failure Assessment (SOFA) scores of the patients were calculated before CVVHDF starts. Hematocrit (Hct), white blood cell, blood pressure, heart rate, and body temperature values were measured and recorded. Procalcitonin (PCT), tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, and IL-1 values on blood were also recorded before the process and at 8, 16, and 24 h of the process. Results: When the AV600S filtered and EMIC-2 filtered groups are compared, TNF-α values are low in the EMIC-2 filtered group (p<0.05). There is no significant difference between the groups with respect to the measurements about APACHE-2, SOFA, IL-1β, IL-6, PCT, Hct, body temperature, mean blood pressures, and heart rate. Conclusion: We think that the filters do not cause a significant change on the elimination of inflammatory cytokines, except TNF-α, on limited numbers of patients who have sepsis with acute renal injury undergoing CVVHDF with EMIC-2 and AV600S.</abstract><cop>Istanbul</cop><pub>Kare Publishing</pub><doi>10.14744/etd.2019.22599</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2149-2247 |
| ispartof | Erciyes Medical Journal, 2020-03, Vol.42 (1), p.54-59 |
| issn | 2149-2247 2980-2156 2149-2247 |
| language | eng |
| recordid | cdi_proquest_journals_2894758863 |
| source | DOAJ Directory of Open Access Journals; ProQuest Central |
| subjects | acute kidney injury continuous venovenous hemodiafiltration inflammatory cytokine sepsis |
| title | The Efficacy of Continuous Venovenous Hemodiafiltration with Cytokine Filter on Sepsis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T23%3A58%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Efficacy%20of%20Continuous%20Venovenous%20Hemodiafiltration%20with%20Cytokine%20Filter%20on%20Sepsis&rft.jtitle=Erciyes%20Medical%20Journal&rft.au=Avc%C4%B1,%20Onur&rft.date=2020-03-01&rft.volume=42&rft.issue=1&rft.spage=54&rft.epage=59&rft.pages=54-59&rft.issn=2149-2247&rft.eissn=2980-2156&rft_id=info:doi/10.14744/etd.2019.22599&rft_dat=%3Cproquest_doaj_%3E2894758863%3C/proquest_doaj_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2894758863&rft_id=info:pmid/&rft_doaj_id=oai_doaj_org_article_df9767fdf5c84adcba488c83a92e367f&rfr_iscdi=true |