Dietary calcium improves the reproductive functions against high-fat diet (HFD)–induced testicular toxicity in male obese rats
Introduction Obesity-associated metabolic disorders are often associated with reproductive disorders affecting the spermatogenesis program and infertility. Recently, dietary calcium has shown a protective effect against obesity and its associated metabolic disorders. Calcium is a common nutrient in...
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| Veröffentlicht in: | Nutrire 2023-11, Vol.48 (2), p.55, Article 55 |
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| creator | Choudhuri, Soma Sarkar, Susmita Chowdhury, Panisree R. Choudhuri, Dipayan Das, Sandeep |
| description | Introduction
Obesity-associated metabolic disorders are often associated with reproductive disorders affecting the spermatogenesis program and infertility. Recently, dietary calcium has shown a protective effect against obesity and its associated metabolic disorders. Calcium is a common nutrient in our daily diet with a diverse physiological role, but its role against reproductive function during obesity remains unknown.
Purpose
The present study aimed to investigate the dietary effect of calcium against male reproductive function in high-fat diet (HFD) rats.
Methods
Male rats were randomly divided into four groups: the control group, the HFD obese group, the low calcium (0.25% Ca) HFD group, and the high calcium (1.0%Ca) HFD group. The rats were fed with the low or high-calcium diet for 12 weeks after inducing obesity. At the end of the study, several reproductive markers including sperm count, testicular steroidogenic enzymatic activity, testosterone, antioxidant, inflammatory and apoptotic markers were studied.
Results
High calcium (1.0% Ca) group was found to improve the reproductive parameters like sperm count, sperm motility, testosterone level, and steroidogenic enzymes indicating improvement in spermatogenesis which is affected by diet-induced obesity. These improvements in reproductive parameters are improved by restoring the physiological balance between antioxidant and oxidative stress levels and reducing the inflammatory and apoptosis markers in the high calcium group.
Conclusion
High calcium diet during obese conditions seemed to improve the male reproductive parameters and spermatogenesis program thereby preventing the risk of obesity-associated male infertility. |
| doi_str_mv | 10.1186/s41110-023-00243-6 |
| format | Article |
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Obesity-associated metabolic disorders are often associated with reproductive disorders affecting the spermatogenesis program and infertility. Recently, dietary calcium has shown a protective effect against obesity and its associated metabolic disorders. Calcium is a common nutrient in our daily diet with a diverse physiological role, but its role against reproductive function during obesity remains unknown.
Purpose
The present study aimed to investigate the dietary effect of calcium against male reproductive function in high-fat diet (HFD) rats.
Methods
Male rats were randomly divided into four groups: the control group, the HFD obese group, the low calcium (0.25% Ca) HFD group, and the high calcium (1.0%Ca) HFD group. The rats were fed with the low or high-calcium diet for 12 weeks after inducing obesity. At the end of the study, several reproductive markers including sperm count, testicular steroidogenic enzymatic activity, testosterone, antioxidant, inflammatory and apoptotic markers were studied.
Results
High calcium (1.0% Ca) group was found to improve the reproductive parameters like sperm count, sperm motility, testosterone level, and steroidogenic enzymes indicating improvement in spermatogenesis which is affected by diet-induced obesity. These improvements in reproductive parameters are improved by restoring the physiological balance between antioxidant and oxidative stress levels and reducing the inflammatory and apoptosis markers in the high calcium group.
Conclusion
High calcium diet during obese conditions seemed to improve the male reproductive parameters and spermatogenesis program thereby preventing the risk of obesity-associated male infertility.</description><identifier>ISSN: 2316-7874</identifier><identifier>ISSN: 1519-8928</identifier><identifier>EISSN: 2316-7874</identifier><identifier>DOI: 10.1186/s41110-023-00243-6</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Antioxidants ; Clinical Nutrition ; Diet ; Enzymes ; Ethylenediaminetetraacetic acid ; Food Science ; Infertility ; Inflammation ; Medicine ; Medicine & Public Health ; Metabolic disorders ; Nutrition ; Obesity ; Physiological aspects ; Physiology ; Sperm ; Spermatogenesis ; Testosterone</subject><ispartof>Nutrire, 2023-11, Vol.48 (2), p.55, Article 55</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>COPYRIGHT 2023 Springer</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c337t-8189d37e50705af70895d60ea9697aa400156f669755314693447bf5173037293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1186/s41110-023-00243-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1186/s41110-023-00243-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Choudhuri, Soma</creatorcontrib><creatorcontrib>Sarkar, Susmita</creatorcontrib><creatorcontrib>Chowdhury, Panisree R.</creatorcontrib><creatorcontrib>Choudhuri, Dipayan</creatorcontrib><creatorcontrib>Das, Sandeep</creatorcontrib><title>Dietary calcium improves the reproductive functions against high-fat diet (HFD)–induced testicular toxicity in male obese rats</title><title>Nutrire</title><addtitle>Nutrire</addtitle><description>Introduction
Obesity-associated metabolic disorders are often associated with reproductive disorders affecting the spermatogenesis program and infertility. Recently, dietary calcium has shown a protective effect against obesity and its associated metabolic disorders. Calcium is a common nutrient in our daily diet with a diverse physiological role, but its role against reproductive function during obesity remains unknown.
Purpose
The present study aimed to investigate the dietary effect of calcium against male reproductive function in high-fat diet (HFD) rats.
Methods
Male rats were randomly divided into four groups: the control group, the HFD obese group, the low calcium (0.25% Ca) HFD group, and the high calcium (1.0%Ca) HFD group. The rats were fed with the low or high-calcium diet for 12 weeks after inducing obesity. At the end of the study, several reproductive markers including sperm count, testicular steroidogenic enzymatic activity, testosterone, antioxidant, inflammatory and apoptotic markers were studied.
Results
High calcium (1.0% Ca) group was found to improve the reproductive parameters like sperm count, sperm motility, testosterone level, and steroidogenic enzymes indicating improvement in spermatogenesis which is affected by diet-induced obesity. These improvements in reproductive parameters are improved by restoring the physiological balance between antioxidant and oxidative stress levels and reducing the inflammatory and apoptosis markers in the high calcium group.
Conclusion
High calcium diet during obese conditions seemed to improve the male reproductive parameters and spermatogenesis program thereby preventing the risk of obesity-associated male infertility.</description><subject>Antioxidants</subject><subject>Clinical Nutrition</subject><subject>Diet</subject><subject>Enzymes</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Food Science</subject><subject>Infertility</subject><subject>Inflammation</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic disorders</subject><subject>Nutrition</subject><subject>Obesity</subject><subject>Physiological aspects</subject><subject>Physiology</subject><subject>Sperm</subject><subject>Spermatogenesis</subject><subject>Testosterone</subject><issn>2316-7874</issn><issn>1519-8928</issn><issn>2316-7874</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9UctOwzAQjBBIIOgPcLLEBQ4BO34lx6pQioTEBc6W69itUeOA7SC49R_4Q76EhSDBCfngXWtmdtZTFMcEnxNSi4vECCG4xBUtMa4YLcVOcVBRIkpZS7b7p94vJik9YoxJVQtJ8EGxvfQ26_iGjN4YP3TId0-xf7EJ5bVF0ULTDib7F4vcEKDoQ0J6pX1IGa39al06nVELIuh0Mb88-9i--wAM26JsU_Zm2OiIcv_qjc9vyAfU6Y1F_dImkNc5HRV7Tm-Snfzch8XD_Op-tihv765vZtPb0lAqc1mTummptBxLzLWTuG54K7DVjWik1gxW4sIJaDinhImGMiaXjhNJMZVVQw-Lk1EXNnoewJp67IcYYKSq6oYR3lRSAOp8RK3ApfLB9TlqA6e1nTd9sM7D-1RKRmsuCANCNRJM7FOK1qmn6Dv4UEWw-kpHjekoSEd9p6O-ptCRlAAcVjb-evmH9Qk_cJIo</recordid><startdate>20231127</startdate><enddate>20231127</enddate><creator>Choudhuri, Soma</creator><creator>Sarkar, Susmita</creator><creator>Chowdhury, Panisree R.</creator><creator>Choudhuri, Dipayan</creator><creator>Das, Sandeep</creator><general>Springer International Publishing</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>3V.</scope><scope>7RV</scope><scope>7XB</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>KB0</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20231127</creationdate><title>Dietary calcium improves the reproductive functions against high-fat diet (HFD)–induced testicular toxicity in male obese rats</title><author>Choudhuri, Soma ; Sarkar, Susmita ; Chowdhury, Panisree R. ; Choudhuri, Dipayan ; Das, Sandeep</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-8189d37e50705af70895d60ea9697aa400156f669755314693447bf5173037293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antioxidants</topic><topic>Clinical Nutrition</topic><topic>Diet</topic><topic>Enzymes</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Food Science</topic><topic>Infertility</topic><topic>Inflammation</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic disorders</topic><topic>Nutrition</topic><topic>Obesity</topic><topic>Physiological aspects</topic><topic>Physiology</topic><topic>Sperm</topic><topic>Spermatogenesis</topic><topic>Testosterone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choudhuri, Soma</creatorcontrib><creatorcontrib>Sarkar, Susmita</creatorcontrib><creatorcontrib>Chowdhury, Panisree R.</creatorcontrib><creatorcontrib>Choudhuri, Dipayan</creatorcontrib><creatorcontrib>Das, Sandeep</creatorcontrib><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Nutrire</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choudhuri, Soma</au><au>Sarkar, Susmita</au><au>Chowdhury, Panisree R.</au><au>Choudhuri, Dipayan</au><au>Das, Sandeep</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary calcium improves the reproductive functions against high-fat diet (HFD)–induced testicular toxicity in male obese rats</atitle><jtitle>Nutrire</jtitle><stitle>Nutrire</stitle><date>2023-11-27</date><risdate>2023</risdate><volume>48</volume><issue>2</issue><spage>55</spage><pages>55-</pages><artnum>55</artnum><issn>2316-7874</issn><issn>1519-8928</issn><eissn>2316-7874</eissn><abstract>Introduction
Obesity-associated metabolic disorders are often associated with reproductive disorders affecting the spermatogenesis program and infertility. Recently, dietary calcium has shown a protective effect against obesity and its associated metabolic disorders. Calcium is a common nutrient in our daily diet with a diverse physiological role, but its role against reproductive function during obesity remains unknown.
Purpose
The present study aimed to investigate the dietary effect of calcium against male reproductive function in high-fat diet (HFD) rats.
Methods
Male rats were randomly divided into four groups: the control group, the HFD obese group, the low calcium (0.25% Ca) HFD group, and the high calcium (1.0%Ca) HFD group. The rats were fed with the low or high-calcium diet for 12 weeks after inducing obesity. At the end of the study, several reproductive markers including sperm count, testicular steroidogenic enzymatic activity, testosterone, antioxidant, inflammatory and apoptotic markers were studied.
Results
High calcium (1.0% Ca) group was found to improve the reproductive parameters like sperm count, sperm motility, testosterone level, and steroidogenic enzymes indicating improvement in spermatogenesis which is affected by diet-induced obesity. These improvements in reproductive parameters are improved by restoring the physiological balance between antioxidant and oxidative stress levels and reducing the inflammatory and apoptosis markers in the high calcium group.
Conclusion
High calcium diet during obese conditions seemed to improve the male reproductive parameters and spermatogenesis program thereby preventing the risk of obesity-associated male infertility.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1186/s41110-023-00243-6</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Antioxidants Clinical Nutrition Diet Enzymes Ethylenediaminetetraacetic acid Food Science Infertility Inflammation Medicine Medicine & Public Health Metabolic disorders Nutrition Obesity Physiological aspects Physiology Sperm Spermatogenesis Testosterone |
| title | Dietary calcium improves the reproductive functions against high-fat diet (HFD)–induced testicular toxicity in male obese rats |
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