Microwave-Assisted Synthesis of New Schiff Bases from Imidazo[1,2-a]pyridine-3-carbaldehyde and Aromatic Amines in PEG-400 as a Green Approach

We have developed a short and highly efficient microwave-enhanced protocol for the synthesis of new Schiff bases, ( E )- N -[(2-arylimidazo[1,2- a ]pyridine-3-yl)methylidene]pyridin-2-amines, by the condensa­tion of 2-arylimidazo[1,2- a ]pyridine-3-carbaldehydes with 2-aminopyridine in polyethylene...

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Veröffentlicht in:Russian journal of organic chemistry 2023-09, Vol.59 (9), p.1620-1624
Hauptverfasser: Atif, H. Y. Saeed, Dengle, S., Parveen, N., Durrani, A. N.
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container_end_page 1624
container_issue 9
container_start_page 1620
container_title Russian journal of organic chemistry
container_volume 59
creator Atif, H. Y. Saeed
Dengle, S.
Parveen, N.
Durrani, A. N.
description We have developed a short and highly efficient microwave-enhanced protocol for the synthesis of new Schiff bases, ( E )- N -[(2-arylimidazo[1,2- a ]pyridine-3-yl)methylidene]pyridin-2-amines, by the condensa­tion of 2-arylimidazo[1,2- a ]pyridine-3-carbaldehydes with 2-aminopyridine in polyethylene glycol-400 as a green reaction medium in the presence of a catalytic amount of acetic acid. The essential features of this protocol are enhanced reaction rate, more eco-friendly reaction conditions, high yields, and green aspects such as avoiding toxic catalysts and hazardous organic solvents and reuse of the reaction medium.
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subjects Acetic acid
Amines
Chemistry
Chemistry and Materials Science
Imines
Organic Chemistry
Polyethylene glycol
Pyridines
Synthesis
title Microwave-Assisted Synthesis of New Schiff Bases from Imidazo[1,2-a]pyridine-3-carbaldehyde and Aromatic Amines in PEG-400 as a Green Approach
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