Synthesis, Molecular Docking, and Biological Activity of Antimetabolites Based on Uracils and 5-Substituted 2,6-Dimethylpyrimidin-4(3H)-ones

5-Substituted 2,4-dimethyl-1,6-dihydropyrimidin-6-ones reacted with aromatic aldehydes to give 5-substituted 2-[( E )-2-arylethenyl]pyrimidin-6-ones, and the reaction of 5-(4-fluorobenzyl)-2,6-dimethylpyrimi­din-4(3 H )-one with 4-fluorobenzaldehyde produced 5-(4-fluorobenzyl)-2,6-bis[( E )-2-(4-flu...

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Veröffentlicht in:	Russian journal of organic chemistry 2023-09, Vol.59 (9), p.1511-1522
Hauptverfasser:	Harutyunyan, A. A., Sumbatyan, A. S., Hambardzumyan, A. A., Panosyan, H. A., Grigoryan, A. S., Stepanyan, H. M., Muradyan, R. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Alkylation Anticancer properties Biological activity Chemical synthesis Chemistry Chemistry and Materials Science Molecular docking Organic Chemistry Substitutes Uracil
Online-Zugang:	Volltext
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