LH Induces De Novo Cholesterol Biosynthesis via SREBP Activation in Granulosa Cells During Ovulation in Female Mice

In the liver, the sterol response element binding protein (SREBP) and the SREBP cleavage-activated protein (SCAP) complex upregulate cholesterol biosynthesis by gene induction of de novo cholesterol synthetic enzymes (Hmgcr, Cyp51, and Dhcr7). Insulin induced gene 1 (INSIG1) negatively regulates cho...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2021-11, Vol.162 (11), p.1
Hauptverfasser:	Nakanishi, Tomoya, Tanaka, Risa, Tonai, Shingo, Lee, Joo Yeon, Yamaoka, Manami, Kawai, Tomoko, Okamoto, Asako, Shimada, Masayuki, Yamashita, Yasuhisa
Format:	Artikel
Sprache:	eng
Schlagworte:	7-Dehydrocholesterol reductase Animals Biosynthesis Cell activation Cells, Cultured Cholesterol Cholesterol - biosynthesis Corpus luteum Down-regulation Endocrinology Enzymes Ethylenediaminetetraacetic acid Fatty acids Female Follicles Gametocytes Gene expression Gene Expression Regulation - drug effects Genes Genetic aspects Gonadotropin Gonadotropins Granulosa cells Granulosa Cells - drug effects Granulosa Cells - metabolism Insulin Lipid Metabolism - drug effects Lipid Metabolism - genetics Luteinizing Hormone - pharmacology Metabolic Networks and Pathways - drug effects Metabolic Networks and Pathways - genetics Mice Mice, Inbred C57BL Ovulation Ovulation - drug effects Ovulation - metabolism Pituitary (anterior) Progesterone Protein binding Proteins siRNA Sterol Regulatory Element Binding Proteins - genetics Sterol Regulatory Element Binding Proteins - metabolism Sterol regulatory element-binding protein Synthesis
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