Strategies and tactics for the synthesis of lipid I and II and shortened analogues: functional building blocks of bacterial cell wall biosynthesis
Covering: the literature up to 2022 This study discusses various synthetic strategies for the synthesis of lipid II, the pivotal bacterial cell wall precursor. In detail, it examines different solution phase approaches, reviews various solid phase sequences, and evaluates enzymatic ventures. The und...
Gespeichert in:
| Veröffentlicht in: | Natural product reports 2023-11, Vol.4 (11), p.1718-1734 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1734 |
|---|---|
| container_issue | 11 |
| container_start_page | 1718 |
| container_title | Natural product reports |
| container_volume | 4 |
| creator | Braun, Christina Wingen, Lukas Martin Menche, Dirk |
| description | Covering: the literature up to 2022
This study discusses various synthetic strategies for the synthesis of lipid II, the pivotal bacterial cell wall precursor. In detail, it examines different solution phase approaches, reviews various solid phase sequences, and evaluates enzymatic ventures. The underlying rationale, scope, limitations, and perspectives of these strategies are discussed. The focus is on the tactics and strategies towards the authentic peptidoglycan compound, as well as analogues thereof with shortened side chains, which are increasingly recognized as more beneficial surrogates with more favorable physicochemical properties.
This review presents an overview of the synthetic approaches towards natural lipid II and shortened analogues made in the last 25 years. Different strategies towards the common target are discussed, and the advantages of each route are indicated. |
| doi_str_mv | 10.1039/d3np00018d |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_journals_2889914898</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2842452983</sourcerecordid><originalsourceid>FETCH-LOGICAL-c296t-6a9938880739af83ecf768885db59e8751914e522c474919d8f6e904eb2fd5af3</originalsourceid><addsrcrecordid>eNpdkU9rGzEQxUVISFw3l9wbBL2Uwrb6s9JKvZWkbQwhKbQ9L1pp5Chdrxxpl5KvkU9c2U5c6EXDaH68N8ND6IySD5Rw_dHxYU0IocodoBmtJanqRrBDNCNMiooIqU7Qq5zvC0IbKY_RCW9qzTRTM_T0Y0xmhGWAjM3g8GjsGGzGPiY83gHOj0MpOWQcPe7DOji82IKLXcl3MY0wgCud6eNygvwJ-2koKrF84G4KvQvDEnd9tL-3Kl2xgBTK0ELf4z-mPF2Ie6fX6MibPsPpc52jX1-__Ly4qq5vvy0uPl9Xlmk5VtJozZVSpOHaeMXB-kaWXrhOaFCNoJrWIBizdbmWaqe8BE1q6Jh3wng-R-92uusUH8reY7sKebOSGSBOuWWqZrVgWvGCvv0PvY9TKvdtKKWLkSrYHL3fUTbFnBP4dp3CyqTHlpJ2k1R7yW--b5O6LPD5s-TUrcDt0ZdoCvBmB6Rs99N_UfO_e0GZOA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2889914898</pqid></control><display><type>article</type><title>Strategies and tactics for the synthesis of lipid I and II and shortened analogues: functional building blocks of bacterial cell wall biosynthesis</title><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Braun, Christina ; Wingen, Lukas Martin ; Menche, Dirk</creator><creatorcontrib>Braun, Christina ; Wingen, Lukas Martin ; Menche, Dirk</creatorcontrib><description>Covering: the literature up to 2022
This study discusses various synthetic strategies for the synthesis of lipid II, the pivotal bacterial cell wall precursor. In detail, it examines different solution phase approaches, reviews various solid phase sequences, and evaluates enzymatic ventures. The underlying rationale, scope, limitations, and perspectives of these strategies are discussed. The focus is on the tactics and strategies towards the authentic peptidoglycan compound, as well as analogues thereof with shortened side chains, which are increasingly recognized as more beneficial surrogates with more favorable physicochemical properties.
This review presents an overview of the synthetic approaches towards natural lipid II and shortened analogues made in the last 25 years. Different strategies towards the common target are discussed, and the advantages of each route are indicated.</description><identifier>ISSN: 0265-0568</identifier><identifier>EISSN: 1460-4752</identifier><identifier>DOI: 10.1039/d3np00018d</identifier><identifier>PMID: 37492928</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Biosynthesis ; Cell walls ; Lipids ; Peptidoglycans ; Physicochemical properties ; Solid phases ; Tactics</subject><ispartof>Natural product reports, 2023-11, Vol.4 (11), p.1718-1734</ispartof><rights>Copyright Royal Society of Chemistry 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c296t-6a9938880739af83ecf768885db59e8751914e522c474919d8f6e904eb2fd5af3</cites><orcidid>0000-0002-4724-8383</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37492928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Braun, Christina</creatorcontrib><creatorcontrib>Wingen, Lukas Martin</creatorcontrib><creatorcontrib>Menche, Dirk</creatorcontrib><title>Strategies and tactics for the synthesis of lipid I and II and shortened analogues: functional building blocks of bacterial cell wall biosynthesis</title><title>Natural product reports</title><addtitle>Nat Prod Rep</addtitle><description>Covering: the literature up to 2022
This study discusses various synthetic strategies for the synthesis of lipid II, the pivotal bacterial cell wall precursor. In detail, it examines different solution phase approaches, reviews various solid phase sequences, and evaluates enzymatic ventures. The underlying rationale, scope, limitations, and perspectives of these strategies are discussed. The focus is on the tactics and strategies towards the authentic peptidoglycan compound, as well as analogues thereof with shortened side chains, which are increasingly recognized as more beneficial surrogates with more favorable physicochemical properties.
This review presents an overview of the synthetic approaches towards natural lipid II and shortened analogues made in the last 25 years. Different strategies towards the common target are discussed, and the advantages of each route are indicated.</description><subject>Biosynthesis</subject><subject>Cell walls</subject><subject>Lipids</subject><subject>Peptidoglycans</subject><subject>Physicochemical properties</subject><subject>Solid phases</subject><subject>Tactics</subject><issn>0265-0568</issn><issn>1460-4752</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkU9rGzEQxUVISFw3l9wbBL2Uwrb6s9JKvZWkbQwhKbQ9L1pp5Chdrxxpl5KvkU9c2U5c6EXDaH68N8ND6IySD5Rw_dHxYU0IocodoBmtJanqRrBDNCNMiooIqU7Qq5zvC0IbKY_RCW9qzTRTM_T0Y0xmhGWAjM3g8GjsGGzGPiY83gHOj0MpOWQcPe7DOji82IKLXcl3MY0wgCud6eNygvwJ-2koKrF84G4KvQvDEnd9tL-3Kl2xgBTK0ELf4z-mPF2Ie6fX6MibPsPpc52jX1-__Ly4qq5vvy0uPl9Xlmk5VtJozZVSpOHaeMXB-kaWXrhOaFCNoJrWIBizdbmWaqe8BE1q6Jh3wng-R-92uusUH8reY7sKebOSGSBOuWWqZrVgWvGCvv0PvY9TKvdtKKWLkSrYHL3fUTbFnBP4dp3CyqTHlpJ2k1R7yW--b5O6LPD5s-TUrcDt0ZdoCvBmB6Rs99N_UfO_e0GZOA</recordid><startdate>20231115</startdate><enddate>20231115</enddate><creator>Braun, Christina</creator><creator>Wingen, Lukas Martin</creator><creator>Menche, Dirk</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4724-8383</orcidid></search><sort><creationdate>20231115</creationdate><title>Strategies and tactics for the synthesis of lipid I and II and shortened analogues: functional building blocks of bacterial cell wall biosynthesis</title><author>Braun, Christina ; Wingen, Lukas Martin ; Menche, Dirk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c296t-6a9938880739af83ecf768885db59e8751914e522c474919d8f6e904eb2fd5af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biosynthesis</topic><topic>Cell walls</topic><topic>Lipids</topic><topic>Peptidoglycans</topic><topic>Physicochemical properties</topic><topic>Solid phases</topic><topic>Tactics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Braun, Christina</creatorcontrib><creatorcontrib>Wingen, Lukas Martin</creatorcontrib><creatorcontrib>Menche, Dirk</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Natural product reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Braun, Christina</au><au>Wingen, Lukas Martin</au><au>Menche, Dirk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Strategies and tactics for the synthesis of lipid I and II and shortened analogues: functional building blocks of bacterial cell wall biosynthesis</atitle><jtitle>Natural product reports</jtitle><addtitle>Nat Prod Rep</addtitle><date>2023-11-15</date><risdate>2023</risdate><volume>4</volume><issue>11</issue><spage>1718</spage><epage>1734</epage><pages>1718-1734</pages><issn>0265-0568</issn><eissn>1460-4752</eissn><abstract>Covering: the literature up to 2022
This study discusses various synthetic strategies for the synthesis of lipid II, the pivotal bacterial cell wall precursor. In detail, it examines different solution phase approaches, reviews various solid phase sequences, and evaluates enzymatic ventures. The underlying rationale, scope, limitations, and perspectives of these strategies are discussed. The focus is on the tactics and strategies towards the authentic peptidoglycan compound, as well as analogues thereof with shortened side chains, which are increasingly recognized as more beneficial surrogates with more favorable physicochemical properties.
This review presents an overview of the synthetic approaches towards natural lipid II and shortened analogues made in the last 25 years. Different strategies towards the common target are discussed, and the advantages of each route are indicated.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>37492928</pmid><doi>10.1039/d3np00018d</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0002-4724-8383</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0265-0568 |
| ispartof | Natural product reports, 2023-11, Vol.4 (11), p.1718-1734 |
| issn | 0265-0568 1460-4752 |
| language | eng |
| recordid | cdi_proquest_journals_2889914898 |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Biosynthesis Cell walls Lipids Peptidoglycans Physicochemical properties Solid phases Tactics |
| title | Strategies and tactics for the synthesis of lipid I and II and shortened analogues: functional building blocks of bacterial cell wall biosynthesis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T21%3A46%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Strategies%20and%20tactics%20for%20the%20synthesis%20of%20lipid%20I%20and%20II%20and%20shortened%20analogues:%20functional%20building%20blocks%20of%20bacterial%20cell%20wall%20biosynthesis&rft.jtitle=Natural%20product%20reports&rft.au=Braun,%20Christina&rft.date=2023-11-15&rft.volume=4&rft.issue=11&rft.spage=1718&rft.epage=1734&rft.pages=1718-1734&rft.issn=0265-0568&rft.eissn=1460-4752&rft_id=info:doi/10.1039/d3np00018d&rft_dat=%3Cproquest_pubme%3E2842452983%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2889914898&rft_id=info:pmid/37492928&rfr_iscdi=true |