Molecular Mechanisms of Valproic Acid Action on Signalling Systems and Brain Functions

Valproic acid (valproate, VA) has been widely used as an antiepileptic agent for several decades, as well as in the treatment of bipolar affective disorder. For many years, the ability of VA to stop different types of epileptic seizures has been associated with increased GABAergic neurotransmission,...

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Veröffentlicht in:	Journal of evolutionary biochemistry and physiology 2023-09, Vol.59 (5), p.1740-1755
Hauptverfasser:	Tursunov, A. N., Vasilyev, D. S., Nalivaeva, N. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Physiology Anticonvulsants Antiepileptic agents Biochemistry Biomedical and Life Sciences DNA methylation Epilepsy Evolutionary Biology Gene expression Glutamatergic transmission Histones Hyperactivity Intracellular signalling Ion channels Life Sciences Molecular modelling Neurotransmission Reviews Seizures Signal transduction Valproic acid γ-Aminobutyric acid
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