Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation

Regulatory T cells (Tregs) are instrumental in maintaining immune tolerance and preventing destructive autoimmunity, but how heterogeneous Treg populations are established remains largely unknown. Here, we show that Zfp33S deletion in Tregs failed to differentiate into effector Tregs (eTregs) and lo...

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Veröffentlicht in:	The Journal of clinical investigation 2023-10, Vol.133 (20), p.1-17
Hauptverfasser:	Wang, Xin, Sun, Lina, Yang, Biao, Li, Wenhua, Zhang, Cangang, Yang, Xiaofeng, Sun, Yae, Shen, Xiaonan, Gao, Yang, Ju, Bomiao, Gao, Yafeng, Liu, Dan, Song, Jiapeng, Jia, Xiaoxuan, Su, Yanhong, Jiao, Anjun, Liu, Haiyan, Zhang, Lianjun, He, Lan, Lei, Lei, Chen, Wanjun, Zhang, Baojun
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Autoimmune diseases Autoimmunity Biomedical research Cell activation Cytokines Enzymes Fatty acids Homeostasis Immunological tolerance Immunoregulation Inflammation Kinases Lymphocytes Lymphocytes T Metabolism Neonates Oxidation Oxidative phosphorylation Phosphorylation Spleen T cell receptors Thymus gland
Online-Zugang:	Volltext
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