New Ruthenium(II)-arene complexes appended curcumin based hydrazones: synthesis, spectral characterization, anti-oxidant and anticancer studies
Curcumin derived Schiff bases and their half-sandwich Ru(II) arene complexes were synthesized and characterized via various spectral techniques. Spectral analysis confirmed the proposed molecular stoichiometry of the complexes, in which the ligands bound to ruthenium ion in a bidentate manner throug...
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| Veröffentlicht in: | Chemical papers 2023-12, Vol.77 (12), p.7725-7736 |
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| creator | Dhatchinamoorthy, M. Gobinath, E. Parveen, S. Dharani, S. Kalaiarasi, G. |
| description | Curcumin derived Schiff bases and their half-sandwich Ru(II) arene complexes were synthesized and characterized via various spectral techniques. Spectral analysis confirmed the proposed molecular stoichiometry of the complexes, in which the ligands bound to ruthenium ion in a bidentate manner through their azomethine nitrogen (neutral coordination) and anionic nitrogen (formed after enolisation). The antioxidant property of the compounds was analyzed in terms of radical scavenging ability with DPPH, ABTS, superoxide, hydroxyl and nitric oxide and the complexes possessed significant antioxidant activity. Anticancer activity was investigated against A549 (human lung cancer) and HeLa (human cervical cancer) cell lines, in which the compounds exhibited an activity better than the standard drugs employed. Overall, the activities of the ruthenium(II) complexes were found to be more than their parent ligands due to chelation and the obtained results highlighted the strong possibility to develop highly active ruthenium arene complexes as anticancer agents.
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| doi_str_mv | 10.1007/s11696-023-03026-5 |
| format | Article |
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Graphical abstract</description><subject>Anticancer properties</subject><subject>Antioxidants</subject><subject>Biochemistry</subject><subject>Biotechnology</subject><subject>Chelation</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Hydrazones</subject><subject>Imines</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Ligands</subject><subject>Materials Science</subject><subject>Medicinal Chemistry</subject><subject>Nitric oxide</subject><subject>Original Paper</subject><subject>Oxidizing agents</subject><subject>Ruthenium</subject><subject>Ruthenium compounds</subject><subject>Scavenging</subject><subject>Spectral methods</subject><subject>Spectrum analysis</subject><subject>Stoichiometry</subject><issn>0366-6352</issn><issn>1336-9075</issn><issn>2585-7290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kEGLFDEQhYMoOK7-AU8BLwobTbqSTMebLOoOLAqi55BJV5wsM-k21c3u7J_wLxt3Frx5qnrFe6_gY-ylkm-VlOt3pJR1VsgOhATZWWEesZUCsMLJtXnMVhKsFRZM95Q9I7qWUmtp5Ir9_oI3_Nsy77Dk5fB6s3kjQsWCPI6HaY-3SDxME5YBBx6XGpdDLnwbqMndcajhbixI7zkdS6ugTOecJoxzDXsed6GGOGPNd2HOYznnocxZjLd5aEsTw_0hhhKxcpqXISM9Z09S2BO-eJhn7Menj98vLsXV18-biw9XIoJys3AuyQHApS10mEAprROsEzqw3RBsH4NJzoIGZaDX0YAE1-sQ0tbosG2pM_bq1DvV8deCNPvrcamlvfRd3xundLeG5upOrlhHoorJTzUfQj16Jf1f8P4E3jfw_h68Ny0EpxA1c_mJ9V_1f1J_APPQiQ0</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Dhatchinamoorthy, M.</creator><creator>Gobinath, E.</creator><creator>Parveen, S.</creator><creator>Dharani, S.</creator><creator>Kalaiarasi, G.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0003-2712-2094</orcidid></search><sort><creationdate>20231201</creationdate><title>New Ruthenium(II)-arene complexes appended curcumin based hydrazones: synthesis, spectral characterization, anti-oxidant and anticancer studies</title><author>Dhatchinamoorthy, M. ; Gobinath, E. ; Parveen, S. ; Dharani, S. ; Kalaiarasi, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-99f0d339fb32ef31144f37fe9362da68ca5f9634315384c5303984aafb54abfb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Anticancer properties</topic><topic>Antioxidants</topic><topic>Biochemistry</topic><topic>Biotechnology</topic><topic>Chelation</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Hydrazones</topic><topic>Imines</topic><topic>Industrial Chemistry/Chemical Engineering</topic><topic>Ligands</topic><topic>Materials Science</topic><topic>Medicinal Chemistry</topic><topic>Nitric oxide</topic><topic>Original Paper</topic><topic>Oxidizing agents</topic><topic>Ruthenium</topic><topic>Ruthenium compounds</topic><topic>Scavenging</topic><topic>Spectral methods</topic><topic>Spectrum analysis</topic><topic>Stoichiometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dhatchinamoorthy, M.</creatorcontrib><creatorcontrib>Gobinath, E.</creatorcontrib><creatorcontrib>Parveen, S.</creatorcontrib><creatorcontrib>Dharani, S.</creatorcontrib><creatorcontrib>Kalaiarasi, G.</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Chemical papers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dhatchinamoorthy, M.</au><au>Gobinath, E.</au><au>Parveen, S.</au><au>Dharani, S.</au><au>Kalaiarasi, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New Ruthenium(II)-arene complexes appended curcumin based hydrazones: synthesis, spectral characterization, anti-oxidant and anticancer studies</atitle><jtitle>Chemical papers</jtitle><stitle>Chem. Pap</stitle><date>2023-12-01</date><risdate>2023</risdate><volume>77</volume><issue>12</issue><spage>7725</spage><epage>7736</epage><pages>7725-7736</pages><issn>0366-6352</issn><eissn>1336-9075</eissn><eissn>2585-7290</eissn><abstract>Curcumin derived Schiff bases and their half-sandwich Ru(II) arene complexes were synthesized and characterized via various spectral techniques. Spectral analysis confirmed the proposed molecular stoichiometry of the complexes, in which the ligands bound to ruthenium ion in a bidentate manner through their azomethine nitrogen (neutral coordination) and anionic nitrogen (formed after enolisation). The antioxidant property of the compounds was analyzed in terms of radical scavenging ability with DPPH, ABTS, superoxide, hydroxyl and nitric oxide and the complexes possessed significant antioxidant activity. Anticancer activity was investigated against A549 (human lung cancer) and HeLa (human cervical cancer) cell lines, in which the compounds exhibited an activity better than the standard drugs employed. Overall, the activities of the ruthenium(II) complexes were found to be more than their parent ligands due to chelation and the obtained results highlighted the strong possibility to develop highly active ruthenium arene complexes as anticancer agents.
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| subjects | Anticancer properties Antioxidants Biochemistry Biotechnology Chelation Chemistry Chemistry and Materials Science Chemistry/Food Science Hydrazones Imines Industrial Chemistry/Chemical Engineering Ligands Materials Science Medicinal Chemistry Nitric oxide Original Paper Oxidizing agents Ruthenium Ruthenium compounds Scavenging Spectral methods Spectrum analysis Stoichiometry |
| title | New Ruthenium(II)-arene complexes appended curcumin based hydrazones: synthesis, spectral characterization, anti-oxidant and anticancer studies |
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