An electrochemical aptasensor based on catalytic hairpin self-assembly and co-amplification of AuPd/Fe-MOF and Au/Cu2O for ultrasensitive detection of Cd2
Cadmium (Cd), a typical heavy metal not essential for the human body, can cause harm to the liver and kidneys upon exposure. Hence, rapid cadmium detection in the environment is of utmost importance. This research presents an effective approach for detecting divalent cadmium ions (Cd 2+ ) using a se...
Gespeichert in:
| Veröffentlicht in: | Chemical papers 2023-12, Vol.77 (12), p.7577-7587 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 7587 |
|---|---|
| container_issue | 12 |
| container_start_page | 7577 |
| container_title | Chemical papers |
| container_volume | 77 |
| creator | He, Jintao Zhang, Baozhong Tian, Panpan Li, Ying Liu, Xiaolong Ma, Xinyue Lin, Min Zhu, Huina Chen, Hanyu Li, Liping He, Baoshan |
| description | Cadmium (Cd), a typical heavy metal not essential for the human body, can cause harm to the liver and kidneys upon exposure. Hence, rapid cadmium detection in the environment is of utmost importance. This research presents an effective approach for detecting divalent cadmium ions (Cd
2+
) using a sensitive dual hairpin (HP) electrochemical aptasensor. The aptasensor incorporates AuPd/Fe-MOF as signal labels and Au/Cu
2
O as the substrate material, and the rapid detection of divalent cadmium ions (Cd
2+
) was based on catalytic hairpin self-assembly (CHA), as the recognition strategy. Au/Cu
2
O increased the specific surface area of the electrode and provided abundant sites for capturing the complementary deoxyribonucleic acid (CDNA) probe. The electrochemical signal is then amplified through synergistic catalytic hydrogen peroxide with AuPd/Fe-MOF, thereby enhancing the aptasensor's sensitivity. Moreover, the dual HP design effectively reduces the likelihood of non-specific capture and minimizes false positives. In this study, various analytical techniques were utilized to characterize the material and evaluate the aptasensor's performance. The morphological characteristics of the material were observed using scanning electron microscopy (SEM). Energy-dispersive spectroscopy (EDS) and X-ray diffraction (XRD) were employed to analyze the elemental composition and distribution of the material, respectively. The electrochemical behavior of the sensor was studied using cyclic voltammetry (CV), while electrochemical impedance spectroscopy (EIS) helped understand the aptasensor's assembly process. Furthermore, the aptasensor's performance was assessed using differential pulse voltammetry (DPV). Under the optimized experimental conditions, the constructed sensor demonstrated effective detection of Cd
2+
in the concentration range of 10
–4
–10 µM, with a remarkably low detection limit of 2.27 × 10
–5
µM. The feasibility of the sensor was validated by successfully detecting Cd
2+
in real water samples.
. |
| doi_str_mv | 10.1007/s11696-023-03082-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2885914228</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2885914228</sourcerecordid><originalsourceid>FETCH-LOGICAL-c200t-5edde90cf70ec55e4c9e523831f25a761cd1a88848690b6f0c78a028713db3113</originalsourceid><addsrcrecordid>eNp9kcFuEzEQhi0EEqHwAj1Z4mwyttde7zGKCCAVpYf2bDn2bOtqs7vYXtS8Sp8Wk1Tixmnm8H__jPQRcs3hCwdo15lz3WkGQjKQYAR7fkNWXErNOmjVW7ICqTXTUon35EPOTwBNAwpW5GUzUhzQlzT5RzxG7wbq5uIyjnlK9FCXQKeRelfccCrR00cX0xxHmnHomcsZj4fhRN0YqJ-YO85D7GtLiRWaerpZbsN6h-znfnfObJb1dhF72tfyZSjpfCiW-BtpwFL_eOW2QXwk73o3ZPz0Oq_I_e7r3fY7u9l_-7Hd3DAvAApTGAJ24PsW0CuFje9QCWkk74VyreY-cGeMaYzu4KB78K1xIEzLZThIzuUV-XzpndP0a8Fc7NO0pLGetMIY1fFGCFNT4pLyaco5YW_nFI8unSwH-9eBvTiw1YE9O7DPFZIXKNfw-IDpX_V_qD_7JItz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2885914228</pqid></control><display><type>article</type><title>An electrochemical aptasensor based on catalytic hairpin self-assembly and co-amplification of AuPd/Fe-MOF and Au/Cu2O for ultrasensitive detection of Cd2</title><source>SpringerLink Journals - AutoHoldings</source><creator>He, Jintao ; Zhang, Baozhong ; Tian, Panpan ; Li, Ying ; Liu, Xiaolong ; Ma, Xinyue ; Lin, Min ; Zhu, Huina ; Chen, Hanyu ; Li, Liping ; He, Baoshan</creator><creatorcontrib>He, Jintao ; Zhang, Baozhong ; Tian, Panpan ; Li, Ying ; Liu, Xiaolong ; Ma, Xinyue ; Lin, Min ; Zhu, Huina ; Chen, Hanyu ; Li, Liping ; He, Baoshan</creatorcontrib><description>Cadmium (Cd), a typical heavy metal not essential for the human body, can cause harm to the liver and kidneys upon exposure. Hence, rapid cadmium detection in the environment is of utmost importance. This research presents an effective approach for detecting divalent cadmium ions (Cd
2+
) using a sensitive dual hairpin (HP) electrochemical aptasensor. The aptasensor incorporates AuPd/Fe-MOF as signal labels and Au/Cu
2
O as the substrate material, and the rapid detection of divalent cadmium ions (Cd
2+
) was based on catalytic hairpin self-assembly (CHA), as the recognition strategy. Au/Cu
2
O increased the specific surface area of the electrode and provided abundant sites for capturing the complementary deoxyribonucleic acid (CDNA) probe. The electrochemical signal is then amplified through synergistic catalytic hydrogen peroxide with AuPd/Fe-MOF, thereby enhancing the aptasensor's sensitivity. Moreover, the dual HP design effectively reduces the likelihood of non-specific capture and minimizes false positives. In this study, various analytical techniques were utilized to characterize the material and evaluate the aptasensor's performance. The morphological characteristics of the material were observed using scanning electron microscopy (SEM). Energy-dispersive spectroscopy (EDS) and X-ray diffraction (XRD) were employed to analyze the elemental composition and distribution of the material, respectively. The electrochemical behavior of the sensor was studied using cyclic voltammetry (CV), while electrochemical impedance spectroscopy (EIS) helped understand the aptasensor's assembly process. Furthermore, the aptasensor's performance was assessed using differential pulse voltammetry (DPV). Under the optimized experimental conditions, the constructed sensor demonstrated effective detection of Cd
2+
in the concentration range of 10
–4
–10 µM, with a remarkably low detection limit of 2.27 × 10
–5
µM. The feasibility of the sensor was validated by successfully detecting Cd
2+
in real water samples.
.</description><identifier>ISSN: 0366-6352</identifier><identifier>EISSN: 1336-9075</identifier><identifier>EISSN: 2585-7290</identifier><identifier>DOI: 10.1007/s11696-023-03082-x</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Amplification ; Biochemistry ; Biotechnology ; Cadmium ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Copper oxides ; Deoxyribonucleic acid ; DNA ; Electrochemical analysis ; Electrochemical impedance spectroscopy ; Gold ; Heavy metals ; Hydrogen peroxide ; Industrial Chemistry/Chemical Engineering ; Intermetallic compounds ; Materials Science ; Medicinal Chemistry ; Metal-organic frameworks ; Original Paper ; Performance evaluation ; Self-assembly ; Sensitivity enhancement ; Sensors ; Spectrum analysis ; Substrates ; Voltammetry ; Water sampling</subject><ispartof>Chemical papers, 2023-12, Vol.77 (12), p.7577-7587</ispartof><rights>The Author(s), under exclusive licence to the Institute of Chemistry, Slovak Academy of Sciences 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c200t-5edde90cf70ec55e4c9e523831f25a761cd1a88848690b6f0c78a028713db3113</cites><orcidid>0000-0002-3842-2407</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11696-023-03082-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11696-023-03082-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids></links><search><creatorcontrib>He, Jintao</creatorcontrib><creatorcontrib>Zhang, Baozhong</creatorcontrib><creatorcontrib>Tian, Panpan</creatorcontrib><creatorcontrib>Li, Ying</creatorcontrib><creatorcontrib>Liu, Xiaolong</creatorcontrib><creatorcontrib>Ma, Xinyue</creatorcontrib><creatorcontrib>Lin, Min</creatorcontrib><creatorcontrib>Zhu, Huina</creatorcontrib><creatorcontrib>Chen, Hanyu</creatorcontrib><creatorcontrib>Li, Liping</creatorcontrib><creatorcontrib>He, Baoshan</creatorcontrib><title>An electrochemical aptasensor based on catalytic hairpin self-assembly and co-amplification of AuPd/Fe-MOF and Au/Cu2O for ultrasensitive detection of Cd2</title><title>Chemical papers</title><addtitle>Chem. Pap</addtitle><description>Cadmium (Cd), a typical heavy metal not essential for the human body, can cause harm to the liver and kidneys upon exposure. Hence, rapid cadmium detection in the environment is of utmost importance. This research presents an effective approach for detecting divalent cadmium ions (Cd
2+
) using a sensitive dual hairpin (HP) electrochemical aptasensor. The aptasensor incorporates AuPd/Fe-MOF as signal labels and Au/Cu
2
O as the substrate material, and the rapid detection of divalent cadmium ions (Cd
2+
) was based on catalytic hairpin self-assembly (CHA), as the recognition strategy. Au/Cu
2
O increased the specific surface area of the electrode and provided abundant sites for capturing the complementary deoxyribonucleic acid (CDNA) probe. The electrochemical signal is then amplified through synergistic catalytic hydrogen peroxide with AuPd/Fe-MOF, thereby enhancing the aptasensor's sensitivity. Moreover, the dual HP design effectively reduces the likelihood of non-specific capture and minimizes false positives. In this study, various analytical techniques were utilized to characterize the material and evaluate the aptasensor's performance. The morphological characteristics of the material were observed using scanning electron microscopy (SEM). Energy-dispersive spectroscopy (EDS) and X-ray diffraction (XRD) were employed to analyze the elemental composition and distribution of the material, respectively. The electrochemical behavior of the sensor was studied using cyclic voltammetry (CV), while electrochemical impedance spectroscopy (EIS) helped understand the aptasensor's assembly process. Furthermore, the aptasensor's performance was assessed using differential pulse voltammetry (DPV). Under the optimized experimental conditions, the constructed sensor demonstrated effective detection of Cd
2+
in the concentration range of 10
–4
–10 µM, with a remarkably low detection limit of 2.27 × 10
–5
µM. The feasibility of the sensor was validated by successfully detecting Cd
2+
in real water samples.
.</description><subject>Amplification</subject><subject>Biochemistry</subject><subject>Biotechnology</subject><subject>Cadmium</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Copper oxides</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Electrochemical analysis</subject><subject>Electrochemical impedance spectroscopy</subject><subject>Gold</subject><subject>Heavy metals</subject><subject>Hydrogen peroxide</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Intermetallic compounds</subject><subject>Materials Science</subject><subject>Medicinal Chemistry</subject><subject>Metal-organic frameworks</subject><subject>Original Paper</subject><subject>Performance evaluation</subject><subject>Self-assembly</subject><subject>Sensitivity enhancement</subject><subject>Sensors</subject><subject>Spectrum analysis</subject><subject>Substrates</subject><subject>Voltammetry</subject><subject>Water sampling</subject><issn>0366-6352</issn><issn>1336-9075</issn><issn>2585-7290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kcFuEzEQhi0EEqHwAj1Z4mwyttde7zGKCCAVpYf2bDn2bOtqs7vYXtS8Sp8Wk1Tixmnm8H__jPQRcs3hCwdo15lz3WkGQjKQYAR7fkNWXErNOmjVW7ICqTXTUon35EPOTwBNAwpW5GUzUhzQlzT5RzxG7wbq5uIyjnlK9FCXQKeRelfccCrR00cX0xxHmnHomcsZj4fhRN0YqJ-YO85D7GtLiRWaerpZbsN6h-znfnfObJb1dhF72tfyZSjpfCiW-BtpwFL_eOW2QXwk73o3ZPz0Oq_I_e7r3fY7u9l_-7Hd3DAvAApTGAJ24PsW0CuFje9QCWkk74VyreY-cGeMaYzu4KB78K1xIEzLZThIzuUV-XzpndP0a8Fc7NO0pLGetMIY1fFGCFNT4pLyaco5YW_nFI8unSwH-9eBvTiw1YE9O7DPFZIXKNfw-IDpX_V_qD_7JItz</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>He, Jintao</creator><creator>Zhang, Baozhong</creator><creator>Tian, Panpan</creator><creator>Li, Ying</creator><creator>Liu, Xiaolong</creator><creator>Ma, Xinyue</creator><creator>Lin, Min</creator><creator>Zhu, Huina</creator><creator>Chen, Hanyu</creator><creator>Li, Liping</creator><creator>He, Baoshan</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0002-3842-2407</orcidid></search><sort><creationdate>20231201</creationdate><title>An electrochemical aptasensor based on catalytic hairpin self-assembly and co-amplification of AuPd/Fe-MOF and Au/Cu2O for ultrasensitive detection of Cd2</title><author>He, Jintao ; Zhang, Baozhong ; Tian, Panpan ; Li, Ying ; Liu, Xiaolong ; Ma, Xinyue ; Lin, Min ; Zhu, Huina ; Chen, Hanyu ; Li, Liping ; He, Baoshan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c200t-5edde90cf70ec55e4c9e523831f25a761cd1a88848690b6f0c78a028713db3113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Amplification</topic><topic>Biochemistry</topic><topic>Biotechnology</topic><topic>Cadmium</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Copper oxides</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Electrochemical analysis</topic><topic>Electrochemical impedance spectroscopy</topic><topic>Gold</topic><topic>Heavy metals</topic><topic>Hydrogen peroxide</topic><topic>Industrial Chemistry/Chemical Engineering</topic><topic>Intermetallic compounds</topic><topic>Materials Science</topic><topic>Medicinal Chemistry</topic><topic>Metal-organic frameworks</topic><topic>Original Paper</topic><topic>Performance evaluation</topic><topic>Self-assembly</topic><topic>Sensitivity enhancement</topic><topic>Sensors</topic><topic>Spectrum analysis</topic><topic>Substrates</topic><topic>Voltammetry</topic><topic>Water sampling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Jintao</creatorcontrib><creatorcontrib>Zhang, Baozhong</creatorcontrib><creatorcontrib>Tian, Panpan</creatorcontrib><creatorcontrib>Li, Ying</creatorcontrib><creatorcontrib>Liu, Xiaolong</creatorcontrib><creatorcontrib>Ma, Xinyue</creatorcontrib><creatorcontrib>Lin, Min</creatorcontrib><creatorcontrib>Zhu, Huina</creatorcontrib><creatorcontrib>Chen, Hanyu</creatorcontrib><creatorcontrib>Li, Liping</creatorcontrib><creatorcontrib>He, Baoshan</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Chemical papers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Jintao</au><au>Zhang, Baozhong</au><au>Tian, Panpan</au><au>Li, Ying</au><au>Liu, Xiaolong</au><au>Ma, Xinyue</au><au>Lin, Min</au><au>Zhu, Huina</au><au>Chen, Hanyu</au><au>Li, Liping</au><au>He, Baoshan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An electrochemical aptasensor based on catalytic hairpin self-assembly and co-amplification of AuPd/Fe-MOF and Au/Cu2O for ultrasensitive detection of Cd2</atitle><jtitle>Chemical papers</jtitle><stitle>Chem. Pap</stitle><date>2023-12-01</date><risdate>2023</risdate><volume>77</volume><issue>12</issue><spage>7577</spage><epage>7587</epage><pages>7577-7587</pages><issn>0366-6352</issn><eissn>1336-9075</eissn><eissn>2585-7290</eissn><abstract>Cadmium (Cd), a typical heavy metal not essential for the human body, can cause harm to the liver and kidneys upon exposure. Hence, rapid cadmium detection in the environment is of utmost importance. This research presents an effective approach for detecting divalent cadmium ions (Cd
2+
) using a sensitive dual hairpin (HP) electrochemical aptasensor. The aptasensor incorporates AuPd/Fe-MOF as signal labels and Au/Cu
2
O as the substrate material, and the rapid detection of divalent cadmium ions (Cd
2+
) was based on catalytic hairpin self-assembly (CHA), as the recognition strategy. Au/Cu
2
O increased the specific surface area of the electrode and provided abundant sites for capturing the complementary deoxyribonucleic acid (CDNA) probe. The electrochemical signal is then amplified through synergistic catalytic hydrogen peroxide with AuPd/Fe-MOF, thereby enhancing the aptasensor's sensitivity. Moreover, the dual HP design effectively reduces the likelihood of non-specific capture and minimizes false positives. In this study, various analytical techniques were utilized to characterize the material and evaluate the aptasensor's performance. The morphological characteristics of the material were observed using scanning electron microscopy (SEM). Energy-dispersive spectroscopy (EDS) and X-ray diffraction (XRD) were employed to analyze the elemental composition and distribution of the material, respectively. The electrochemical behavior of the sensor was studied using cyclic voltammetry (CV), while electrochemical impedance spectroscopy (EIS) helped understand the aptasensor's assembly process. Furthermore, the aptasensor's performance was assessed using differential pulse voltammetry (DPV). Under the optimized experimental conditions, the constructed sensor demonstrated effective detection of Cd
2+
in the concentration range of 10
–4
–10 µM, with a remarkably low detection limit of 2.27 × 10
–5
µM. The feasibility of the sensor was validated by successfully detecting Cd
2+
in real water samples.
.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s11696-023-03082-x</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-3842-2407</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0366-6352 |
| ispartof | Chemical papers, 2023-12, Vol.77 (12), p.7577-7587 |
| issn | 0366-6352 1336-9075 2585-7290 |
| language | eng |
| recordid | cdi_proquest_journals_2885914228 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Amplification Biochemistry Biotechnology Cadmium Chemistry Chemistry and Materials Science Chemistry/Food Science Copper oxides Deoxyribonucleic acid DNA Electrochemical analysis Electrochemical impedance spectroscopy Gold Heavy metals Hydrogen peroxide Industrial Chemistry/Chemical Engineering Intermetallic compounds Materials Science Medicinal Chemistry Metal-organic frameworks Original Paper Performance evaluation Self-assembly Sensitivity enhancement Sensors Spectrum analysis Substrates Voltammetry Water sampling |
| title | An electrochemical aptasensor based on catalytic hairpin self-assembly and co-amplification of AuPd/Fe-MOF and Au/Cu2O for ultrasensitive detection of Cd2 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T01%3A03%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20electrochemical%20aptasensor%20based%20on%20catalytic%20hairpin%20self-assembly%20and%20co-amplification%20of%20AuPd/Fe-MOF%20and%20Au/Cu2O%20for%20ultrasensitive%20detection%20of%20Cd2&rft.jtitle=Chemical%20papers&rft.au=He,%20Jintao&rft.date=2023-12-01&rft.volume=77&rft.issue=12&rft.spage=7577&rft.epage=7587&rft.pages=7577-7587&rft.issn=0366-6352&rft.eissn=1336-9075&rft_id=info:doi/10.1007/s11696-023-03082-x&rft_dat=%3Cproquest_cross%3E2885914228%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2885914228&rft_id=info:pmid/&rfr_iscdi=true |