Dynamic ultrasound focusing and centimeter-scale ex vivo tissue ablations with a CMUT probe developed for endocavitary HIFU therapies
Thermal ablation of localized prostate tumors via endocavitary Ultrasound-guided High Intensity Focused Ultrasound (USgHIFU) faces challenges that could be alleviated by better integration of dual modalities (imaging/therapy). Capacitive Micromachined Ultrasound Transducers (CMUTs) may provide an al...
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creator | Suarez-Castellanos, Ivan M. De Sallmard, Geoffroy Vanstaevel, Guillaume Ganeau, Alice Bawiec, Christopher Chapelon, Jean-Yves Guillen, Nicolas Senegond, Nicolas N'Djin, W. Apoutou |
description | Thermal ablation of localized prostate tumors via endocavitary Ultrasound-guided High Intensity Focused Ultrasound (USgHIFU) faces challenges that could be alleviated by better integration of dual modalities (imaging/therapy). Capacitive Micromachined Ultrasound Transducers (CMUTs) may provide an alternative to existing piezoelectric technologies by exhibiting advanced integration capability through miniaturization, broad frequency bandwidth and potential for high electro-acoustic efficiency. An endocavitary dual-mode USgHIFU probe was built to investigate the potential of using CMUT technologies for transrectal prostate cancer ablative therapy. The USgHIFU probe included a planar 64-element annular HIFU CMUT array ( fHIFU = 3 MHz) surrounding a 256-element linear imaging CMUT array. Acoustic characterization of the HIFU array included 3D pressure field mapping and radiation force balance measurements. Ex vivo proof-of-concept experiments consisted in generating HIFU thermal ablations with the CMUT probe on porcine liver tissues. The planar CMUT probe enabled HIFU dynamic focusing (distance range: 32 - 72 mm) while providing acoustic surface intensities of 1 W/cm 2 that allowed producing elementary ex vivo ablations in depth of liver tissue (L×W ≈ 10 mm × 5 mm). Combinations of dynamic focusing, along with probe rotation and translation produced larger thermal ablations (L×W ≈ 20 mm × 20 mm) by juxtaposing multiple elementary ablations, consistent with expected results obtained through numerical modeling. The technical feasibility of using a USgHIFU probe, fully-developed using CMUTs for tissue ablation purposes, was demonstrated. The HIFU-CMUT array showed tissue ablation capabilities with volumes compatible with localized cancer targeting thus providing assets for further development of focal therapies. |
doi_str_mv | 10.1109/TUFFC.2023.3301977 |
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Apoutou</creator><creatorcontrib>Suarez-Castellanos, Ivan M. ; De Sallmard, Geoffroy ; Vanstaevel, Guillaume ; Ganeau, Alice ; Bawiec, Christopher ; Chapelon, Jean-Yves ; Guillen, Nicolas ; Senegond, Nicolas ; N'Djin, W. Apoutou</creatorcontrib><description>Thermal ablation of localized prostate tumors via endocavitary Ultrasound-guided High Intensity Focused Ultrasound (USgHIFU) faces challenges that could be alleviated by better integration of dual modalities (imaging/therapy). Capacitive Micromachined Ultrasound Transducers (CMUTs) may provide an alternative to existing piezoelectric technologies by exhibiting advanced integration capability through miniaturization, broad frequency bandwidth and potential for high electro-acoustic efficiency. An endocavitary dual-mode USgHIFU probe was built to investigate the potential of using CMUT technologies for transrectal prostate cancer ablative therapy. The USgHIFU probe included a planar 64-element annular HIFU CMUT array ( fHIFU = 3 MHz) surrounding a 256-element linear imaging CMUT array. Acoustic characterization of the HIFU array included 3D pressure field mapping and radiation force balance measurements. Ex vivo proof-of-concept experiments consisted in generating HIFU thermal ablations with the CMUT probe on porcine liver tissues. The planar CMUT probe enabled HIFU dynamic focusing (distance range: 32 - 72 mm) while providing acoustic surface intensities of 1 W/cm 2 that allowed producing elementary ex vivo ablations in depth of liver tissue (L×W ≈ 10 mm × 5 mm). Combinations of dynamic focusing, along with probe rotation and translation produced larger thermal ablations (L×W ≈ 20 mm × 20 mm) by juxtaposing multiple elementary ablations, consistent with expected results obtained through numerical modeling. The technical feasibility of using a USgHIFU probe, fully-developed using CMUTs for tissue ablation purposes, was demonstrated. The HIFU-CMUT array showed tissue ablation capabilities with volumes compatible with localized cancer targeting thus providing assets for further development of focal therapies.</description><identifier>ISSN: 0885-3010</identifier><identifier>EISSN: 1525-8955</identifier><identifier>DOI: 10.1109/TUFFC.2023.3301977</identifier><identifier>PMID: 37540608</identifier><identifier>CODEN: ITUCER</identifier><language>eng</language><publisher>United States: IEEE</publisher><subject>Ablation ; Acoustic mapping ; Acoustics ; Arrays ; Dynamic focusing ; High intensity focused ultrasound (HIFU) ; High Power Ultrasound ; Hyperthermia and surgery ; Liver ; Medical imaging ; Medical treatment ; Micromachined Ultrasound Transducers ; Micromachining ; Numerical models ; Piezoelectricity ; Probes ; Prostate cancer ; System & device design ; Technology assessment ; Transducers ; Tumors ; Ultrasonic imaging</subject><ispartof>IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2023-11, Vol.PP (11), p.1-1</ispartof><rights>Copyright The Institute of Electrical and Electronics Engineers, Inc. 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Apoutou</creatorcontrib><title>Dynamic ultrasound focusing and centimeter-scale ex vivo tissue ablations with a CMUT probe developed for endocavitary HIFU therapies</title><title>IEEE transactions on ultrasonics, ferroelectrics, and frequency control</title><addtitle>T-UFFC</addtitle><addtitle>IEEE Trans Ultrason Ferroelectr Freq Control</addtitle><description>Thermal ablation of localized prostate tumors via endocavitary Ultrasound-guided High Intensity Focused Ultrasound (USgHIFU) faces challenges that could be alleviated by better integration of dual modalities (imaging/therapy). Capacitive Micromachined Ultrasound Transducers (CMUTs) may provide an alternative to existing piezoelectric technologies by exhibiting advanced integration capability through miniaturization, broad frequency bandwidth and potential for high electro-acoustic efficiency. An endocavitary dual-mode USgHIFU probe was built to investigate the potential of using CMUT technologies for transrectal prostate cancer ablative therapy. The USgHIFU probe included a planar 64-element annular HIFU CMUT array ( fHIFU = 3 MHz) surrounding a 256-element linear imaging CMUT array. Acoustic characterization of the HIFU array included 3D pressure field mapping and radiation force balance measurements. Ex vivo proof-of-concept experiments consisted in generating HIFU thermal ablations with the CMUT probe on porcine liver tissues. The planar CMUT probe enabled HIFU dynamic focusing (distance range: 32 - 72 mm) while providing acoustic surface intensities of 1 W/cm 2 that allowed producing elementary ex vivo ablations in depth of liver tissue (L×W ≈ 10 mm × 5 mm). Combinations of dynamic focusing, along with probe rotation and translation produced larger thermal ablations (L×W ≈ 20 mm × 20 mm) by juxtaposing multiple elementary ablations, consistent with expected results obtained through numerical modeling. The technical feasibility of using a USgHIFU probe, fully-developed using CMUTs for tissue ablation purposes, was demonstrated. The HIFU-CMUT array showed tissue ablation capabilities with volumes compatible with localized cancer targeting thus providing assets for further development of focal therapies.</description><subject>Ablation</subject><subject>Acoustic mapping</subject><subject>Acoustics</subject><subject>Arrays</subject><subject>Dynamic focusing</subject><subject>High intensity focused ultrasound (HIFU)</subject><subject>High Power Ultrasound</subject><subject>Hyperthermia and surgery</subject><subject>Liver</subject><subject>Medical imaging</subject><subject>Medical treatment</subject><subject>Micromachined Ultrasound Transducers</subject><subject>Micromachining</subject><subject>Numerical models</subject><subject>Piezoelectricity</subject><subject>Probes</subject><subject>Prostate cancer</subject><subject>System & device design</subject><subject>Technology assessment</subject><subject>Transducers</subject><subject>Tumors</subject><subject>Ultrasonic imaging</subject><issn>0885-3010</issn><issn>1525-8955</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>RIE</sourceid><recordid>eNpdkc9O3DAQhy3UChbaF6iqyhKXXrL4b2Ifq4UFJCouu-fIiSfFKIm3trMtD8B718tuEeI0Gs03P83oQ-gLJXNKib5YrZfLxZwRxuecE6qr6gjNqGSyUFrKD2hGlJJFnpATdBrjIyFUCM2O0QmvpCAlUTP0fPk0msG1eOpTMNFPo8Wdb6foxl_Y5KaFMbkBEoQitqYHDH_x1m09Ti7GCbBpepOcHyP-49IDNnjxc73Cm-AbwBa20PsN7CIDhtH61mxdMuEJ39wu1zg9QDAbB_ET-tiZPsLnQz1D6-XVanFT3N1f3y5-3BUtJzwVlSJMGFbxEhrTCcm4pZZxxaTSrDGgSjCdbaAT1paVNEIJKyUrNWkkMMX4Gfq-z833_Z4gpnpwsYW-NyP4KdZMiVJnUO_Q83foo5_CmK_LlBJKCyKqTLE91QYfY4Cu3gQ35AdrSuqdpPpFUr2TVB8k5aVvh-ipGcC-rvy3koGve8ABwJtERjQTlP8D5raXLQ</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Suarez-Castellanos, Ivan M.</creator><creator>De Sallmard, Geoffroy</creator><creator>Vanstaevel, Guillaume</creator><creator>Ganeau, Alice</creator><creator>Bawiec, Christopher</creator><creator>Chapelon, Jean-Yves</creator><creator>Guillen, Nicolas</creator><creator>Senegond, Nicolas</creator><creator>N'Djin, W. Apoutou</creator><general>IEEE</general><general>The Institute of Electrical and Electronics Engineers, Inc. (IEEE)</general><scope>97E</scope><scope>RIA</scope><scope>RIE</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0606-1464</orcidid><orcidid>https://orcid.org/0000-0003-0642-1132</orcidid><orcidid>https://orcid.org/0000-0001-6575-0775</orcidid></search><sort><creationdate>20231101</creationdate><title>Dynamic ultrasound focusing and centimeter-scale ex vivo tissue ablations with a CMUT probe developed for endocavitary HIFU therapies</title><author>Suarez-Castellanos, Ivan M. ; De Sallmard, Geoffroy ; Vanstaevel, Guillaume ; Ganeau, Alice ; Bawiec, Christopher ; Chapelon, Jean-Yves ; Guillen, Nicolas ; Senegond, Nicolas ; N'Djin, W. Apoutou</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-78024a2736ebaf4523d1d23825892bae86eafdbef4dd675a484d552690b5e2823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Ablation</topic><topic>Acoustic mapping</topic><topic>Acoustics</topic><topic>Arrays</topic><topic>Dynamic focusing</topic><topic>High intensity focused ultrasound (HIFU)</topic><topic>High Power Ultrasound</topic><topic>Hyperthermia and surgery</topic><topic>Liver</topic><topic>Medical imaging</topic><topic>Medical treatment</topic><topic>Micromachined Ultrasound Transducers</topic><topic>Micromachining</topic><topic>Numerical models</topic><topic>Piezoelectricity</topic><topic>Probes</topic><topic>Prostate cancer</topic><topic>System & device design</topic><topic>Technology assessment</topic><topic>Transducers</topic><topic>Tumors</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suarez-Castellanos, Ivan M.</creatorcontrib><creatorcontrib>De Sallmard, Geoffroy</creatorcontrib><creatorcontrib>Vanstaevel, Guillaume</creatorcontrib><creatorcontrib>Ganeau, Alice</creatorcontrib><creatorcontrib>Bawiec, Christopher</creatorcontrib><creatorcontrib>Chapelon, Jean-Yves</creatorcontrib><creatorcontrib>Guillen, Nicolas</creatorcontrib><creatorcontrib>Senegond, Nicolas</creatorcontrib><creatorcontrib>N'Djin, W. Apoutou</creatorcontrib><collection>IEEE All-Society Periodicals Package (ASPP) 2005-present</collection><collection>IEEE All-Society Periodicals Package (ASPP) 1998-Present</collection><collection>IEEE Electronic Library (IEL)</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>IEEE transactions on ultrasonics, ferroelectrics, and frequency control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Suarez-Castellanos, Ivan M.</au><au>De Sallmard, Geoffroy</au><au>Vanstaevel, Guillaume</au><au>Ganeau, Alice</au><au>Bawiec, Christopher</au><au>Chapelon, Jean-Yves</au><au>Guillen, Nicolas</au><au>Senegond, Nicolas</au><au>N'Djin, W. Apoutou</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic ultrasound focusing and centimeter-scale ex vivo tissue ablations with a CMUT probe developed for endocavitary HIFU therapies</atitle><jtitle>IEEE transactions on ultrasonics, ferroelectrics, and frequency control</jtitle><stitle>T-UFFC</stitle><addtitle>IEEE Trans Ultrason Ferroelectr Freq Control</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>PP</volume><issue>11</issue><spage>1</spage><epage>1</epage><pages>1-1</pages><issn>0885-3010</issn><eissn>1525-8955</eissn><coden>ITUCER</coden><abstract>Thermal ablation of localized prostate tumors via endocavitary Ultrasound-guided High Intensity Focused Ultrasound (USgHIFU) faces challenges that could be alleviated by better integration of dual modalities (imaging/therapy). Capacitive Micromachined Ultrasound Transducers (CMUTs) may provide an alternative to existing piezoelectric technologies by exhibiting advanced integration capability through miniaturization, broad frequency bandwidth and potential for high electro-acoustic efficiency. An endocavitary dual-mode USgHIFU probe was built to investigate the potential of using CMUT technologies for transrectal prostate cancer ablative therapy. The USgHIFU probe included a planar 64-element annular HIFU CMUT array ( fHIFU = 3 MHz) surrounding a 256-element linear imaging CMUT array. Acoustic characterization of the HIFU array included 3D pressure field mapping and radiation force balance measurements. Ex vivo proof-of-concept experiments consisted in generating HIFU thermal ablations with the CMUT probe on porcine liver tissues. The planar CMUT probe enabled HIFU dynamic focusing (distance range: 32 - 72 mm) while providing acoustic surface intensities of 1 W/cm 2 that allowed producing elementary ex vivo ablations in depth of liver tissue (L×W ≈ 10 mm × 5 mm). Combinations of dynamic focusing, along with probe rotation and translation produced larger thermal ablations (L×W ≈ 20 mm × 20 mm) by juxtaposing multiple elementary ablations, consistent with expected results obtained through numerical modeling. The technical feasibility of using a USgHIFU probe, fully-developed using CMUTs for tissue ablation purposes, was demonstrated. The HIFU-CMUT array showed tissue ablation capabilities with volumes compatible with localized cancer targeting thus providing assets for further development of focal therapies.</abstract><cop>United States</cop><pub>IEEE</pub><pmid>37540608</pmid><doi>10.1109/TUFFC.2023.3301977</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-0606-1464</orcidid><orcidid>https://orcid.org/0000-0003-0642-1132</orcidid><orcidid>https://orcid.org/0000-0001-6575-0775</orcidid></addata></record> |
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subjects | Ablation Acoustic mapping Acoustics Arrays Dynamic focusing High intensity focused ultrasound (HIFU) High Power Ultrasound Hyperthermia and surgery Liver Medical imaging Medical treatment Micromachined Ultrasound Transducers Micromachining Numerical models Piezoelectricity Probes Prostate cancer System & device design Technology assessment Transducers Tumors Ultrasonic imaging |
title | Dynamic ultrasound focusing and centimeter-scale ex vivo tissue ablations with a CMUT probe developed for endocavitary HIFU therapies |
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