Drug Release and Biocompatibility of a Paclitaxel-Coated Balloon Prepared Using the Electrostatic Spray Method

Paclitaxel-coated balloons (PCBs) have become effective treatment options for vascular disease, but long-term drug release and biocompatibility are influenced by the drug patterns. In this work, paclitaxel coatings were prepared via electrostatic spraying, and the effect of D-tartaric acid additives...

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Veröffentlicht in:Coatings (Basel) 2023-10, Vol.13 (10), p.1674
Hauptverfasser: Yang, Xi, Liu, Hengquan, He, Junxi, Hu, Qiong, Pan, Changjiang, Wang, Dongfang, Li, Junfeng, Liu, Chunhai, Huang, Ming, Xiang, Qian, Liu, Ren
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container_issue 10
container_start_page 1674
container_title Coatings (Basel)
container_volume 13
creator Yang, Xi
Liu, Hengquan
He, Junxi
Hu, Qiong
Pan, Changjiang
Wang, Dongfang
Li, Junfeng
Liu, Chunhai
Huang, Ming
Xiang, Qian
Liu, Ren
description Paclitaxel-coated balloons (PCBs) have become effective treatment options for vascular disease, but long-term drug release and biocompatibility are influenced by the drug patterns. In this work, paclitaxel coatings were prepared via electrostatic spraying, and the effect of D-tartaric acid additives was investigated. Microstructures and surface morphology were studied using Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM), respectively. Drug release was measured in vitro, and biocompatibility was evaluated using the haemolysis rate, platelet adhesion and activation, protein adsorption, cell adhesion, and cell proliferation. Our results showed that a uniform crystalline paclitaxel drug coating was obtained, and that the pattern and release of paclitaxel was influenced by the content of D-tartrate. The contact angle of all coatings was less than that of nylon 12. The drug coatings prepared at a mass ratio of paclitaxel to D-tartaric acid of 2:1 had the highest drug release in a brief period of time. The haemolysis rate of the drug coating was less than 5%. Compared with the control samples, platelet adhesion and activation were significantly reduced, albumin adsorption was increased, and the adsorption of fibrinogen was reduced on the surface of the drug coating. Endothelial cells demonstrated good proliferation after three days of cell culture. Therefore, PCBs with specific patterns have good biocompatibility and drug release, with potential clinical applications in vascular disease.
doi_str_mv 10.3390/coatings13101674
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In this work, paclitaxel coatings were prepared via electrostatic spraying, and the effect of D-tartaric acid additives was investigated. Microstructures and surface morphology were studied using Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM), respectively. Drug release was measured in vitro, and biocompatibility was evaluated using the haemolysis rate, platelet adhesion and activation, protein adsorption, cell adhesion, and cell proliferation. Our results showed that a uniform crystalline paclitaxel drug coating was obtained, and that the pattern and release of paclitaxel was influenced by the content of D-tartrate. The contact angle of all coatings was less than that of nylon 12. The drug coatings prepared at a mass ratio of paclitaxel to D-tartaric acid of 2:1 had the highest drug release in a brief period of time. The haemolysis rate of the drug coating was less than 5%. Compared with the control samples, platelet adhesion and activation were significantly reduced, albumin adsorption was increased, and the adsorption of fibrinogen was reduced on the surface of the drug coating. Endothelial cells demonstrated good proliferation after three days of cell culture. Therefore, PCBs with specific patterns have good biocompatibility and drug release, with potential clinical applications in vascular disease.</description><identifier>ISSN: 2079-6412</identifier><identifier>EISSN: 2079-6412</identifier><identifier>DOI: 10.3390/coatings13101674</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Additives ; Adsorption ; Albumin ; Analysis ; Antibodies ; Anticoagulants ; Biocompatibility ; Blood circulation disorders ; Blood platelets ; Blood vessels ; Cell adhesion ; Coatings ; Contact angle ; Endothelial cells ; Fibrin ; Fibrinogen ; Fourier transforms ; Hemolysis ; Infrared spectroscopy ; Methods ; Morphology ; Nylon 12 ; Paclitaxel ; Power supply ; Product introduction ; Protein adsorption ; Proteins ; Scanning electron microscopy ; Smooth muscle ; Spraying ; Stents ; Surface chemistry ; Tartaric acid</subject><ispartof>Coatings (Basel), 2023-10, Vol.13 (10), p.1674</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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In this work, paclitaxel coatings were prepared via electrostatic spraying, and the effect of D-tartaric acid additives was investigated. Microstructures and surface morphology were studied using Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM), respectively. Drug release was measured in vitro, and biocompatibility was evaluated using the haemolysis rate, platelet adhesion and activation, protein adsorption, cell adhesion, and cell proliferation. Our results showed that a uniform crystalline paclitaxel drug coating was obtained, and that the pattern and release of paclitaxel was influenced by the content of D-tartrate. The contact angle of all coatings was less than that of nylon 12. The drug coatings prepared at a mass ratio of paclitaxel to D-tartaric acid of 2:1 had the highest drug release in a brief period of time. The haemolysis rate of the drug coating was less than 5%. Compared with the control samples, platelet adhesion and activation were significantly reduced, albumin adsorption was increased, and the adsorption of fibrinogen was reduced on the surface of the drug coating. Endothelial cells demonstrated good proliferation after three days of cell culture. Therefore, PCBs with specific patterns have good biocompatibility and drug release, with potential clinical applications in vascular disease.</abstract><cop>Basel</cop><pub>MDPI AG</pub><doi>10.3390/coatings13101674</doi><orcidid>https://orcid.org/0000-0003-3138-8389</orcidid><orcidid>https://orcid.org/0000-0002-6733-5089</orcidid><orcidid>https://orcid.org/0009-0005-6005-3758</orcidid><oa>free_for_read</oa></addata></record>
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source MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection
subjects Additives
Adsorption
Albumin
Analysis
Antibodies
Anticoagulants
Biocompatibility
Blood circulation disorders
Blood platelets
Blood vessels
Cell adhesion
Coatings
Contact angle
Endothelial cells
Fibrin
Fibrinogen
Fourier transforms
Hemolysis
Infrared spectroscopy
Methods
Morphology
Nylon 12
Paclitaxel
Power supply
Product introduction
Protein adsorption
Proteins
Scanning electron microscopy
Smooth muscle
Spraying
Stents
Surface chemistry
Tartaric acid
title Drug Release and Biocompatibility of a Paclitaxel-Coated Balloon Prepared Using the Electrostatic Spray Method
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