Drug Release and Biocompatibility of a Paclitaxel-Coated Balloon Prepared Using the Electrostatic Spray Method
Paclitaxel-coated balloons (PCBs) have become effective treatment options for vascular disease, but long-term drug release and biocompatibility are influenced by the drug patterns. In this work, paclitaxel coatings were prepared via electrostatic spraying, and the effect of D-tartaric acid additives...
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Veröffentlicht in: | Coatings (Basel) 2023-10, Vol.13 (10), p.1674 |
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description | Paclitaxel-coated balloons (PCBs) have become effective treatment options for vascular disease, but long-term drug release and biocompatibility are influenced by the drug patterns. In this work, paclitaxel coatings were prepared via electrostatic spraying, and the effect of D-tartaric acid additives was investigated. Microstructures and surface morphology were studied using Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM), respectively. Drug release was measured in vitro, and biocompatibility was evaluated using the haemolysis rate, platelet adhesion and activation, protein adsorption, cell adhesion, and cell proliferation. Our results showed that a uniform crystalline paclitaxel drug coating was obtained, and that the pattern and release of paclitaxel was influenced by the content of D-tartrate. The contact angle of all coatings was less than that of nylon 12. The drug coatings prepared at a mass ratio of paclitaxel to D-tartaric acid of 2:1 had the highest drug release in a brief period of time. The haemolysis rate of the drug coating was less than 5%. Compared with the control samples, platelet adhesion and activation were significantly reduced, albumin adsorption was increased, and the adsorption of fibrinogen was reduced on the surface of the drug coating. Endothelial cells demonstrated good proliferation after three days of cell culture. Therefore, PCBs with specific patterns have good biocompatibility and drug release, with potential clinical applications in vascular disease. |
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In this work, paclitaxel coatings were prepared via electrostatic spraying, and the effect of D-tartaric acid additives was investigated. Microstructures and surface morphology were studied using Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM), respectively. Drug release was measured in vitro, and biocompatibility was evaluated using the haemolysis rate, platelet adhesion and activation, protein adsorption, cell adhesion, and cell proliferation. Our results showed that a uniform crystalline paclitaxel drug coating was obtained, and that the pattern and release of paclitaxel was influenced by the content of D-tartrate. The contact angle of all coatings was less than that of nylon 12. The drug coatings prepared at a mass ratio of paclitaxel to D-tartaric acid of 2:1 had the highest drug release in a brief period of time. The haemolysis rate of the drug coating was less than 5%. Compared with the control samples, platelet adhesion and activation were significantly reduced, albumin adsorption was increased, and the adsorption of fibrinogen was reduced on the surface of the drug coating. Endothelial cells demonstrated good proliferation after three days of cell culture. Therefore, PCBs with specific patterns have good biocompatibility and drug release, with potential clinical applications in vascular disease.</description><identifier>ISSN: 2079-6412</identifier><identifier>EISSN: 2079-6412</identifier><identifier>DOI: 10.3390/coatings13101674</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Additives ; Adsorption ; Albumin ; Analysis ; Antibodies ; Anticoagulants ; Biocompatibility ; Blood circulation disorders ; Blood platelets ; Blood vessels ; Cell adhesion ; Coatings ; Contact angle ; Endothelial cells ; Fibrin ; Fibrinogen ; Fourier transforms ; Hemolysis ; Infrared spectroscopy ; Methods ; Morphology ; Nylon 12 ; Paclitaxel ; Power supply ; Product introduction ; Protein adsorption ; Proteins ; Scanning electron microscopy ; Smooth muscle ; Spraying ; Stents ; Surface chemistry ; Tartaric acid</subject><ispartof>Coatings (Basel), 2023-10, Vol.13 (10), p.1674</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c333t-7c890a203e3107e6369987f181486d6188b2964027ac530d4f8ac95e8ce31fb83</cites><orcidid>0000-0003-3138-8389 ; 0000-0002-6733-5089 ; 0009-0005-6005-3758</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Yang, Xi</creatorcontrib><creatorcontrib>Liu, Hengquan</creatorcontrib><creatorcontrib>He, Junxi</creatorcontrib><creatorcontrib>Hu, Qiong</creatorcontrib><creatorcontrib>Pan, Changjiang</creatorcontrib><creatorcontrib>Wang, Dongfang</creatorcontrib><creatorcontrib>Li, Junfeng</creatorcontrib><creatorcontrib>Liu, Chunhai</creatorcontrib><creatorcontrib>Huang, Ming</creatorcontrib><creatorcontrib>Xiang, Qian</creatorcontrib><creatorcontrib>Liu, Ren</creatorcontrib><title>Drug Release and Biocompatibility of a Paclitaxel-Coated Balloon Prepared Using the Electrostatic Spray Method</title><title>Coatings (Basel)</title><description>Paclitaxel-coated balloons (PCBs) have become effective treatment options for vascular disease, but long-term drug release and biocompatibility are influenced by the drug patterns. In this work, paclitaxel coatings were prepared via electrostatic spraying, and the effect of D-tartaric acid additives was investigated. Microstructures and surface morphology were studied using Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM), respectively. Drug release was measured in vitro, and biocompatibility was evaluated using the haemolysis rate, platelet adhesion and activation, protein adsorption, cell adhesion, and cell proliferation. Our results showed that a uniform crystalline paclitaxel drug coating was obtained, and that the pattern and release of paclitaxel was influenced by the content of D-tartrate. The contact angle of all coatings was less than that of nylon 12. The drug coatings prepared at a mass ratio of paclitaxel to D-tartaric acid of 2:1 had the highest drug release in a brief period of time. The haemolysis rate of the drug coating was less than 5%. Compared with the control samples, platelet adhesion and activation were significantly reduced, albumin adsorption was increased, and the adsorption of fibrinogen was reduced on the surface of the drug coating. Endothelial cells demonstrated good proliferation after three days of cell culture. Therefore, PCBs with specific patterns have good biocompatibility and drug release, with potential clinical applications in vascular disease.</description><subject>Additives</subject><subject>Adsorption</subject><subject>Albumin</subject><subject>Analysis</subject><subject>Antibodies</subject><subject>Anticoagulants</subject><subject>Biocompatibility</subject><subject>Blood circulation disorders</subject><subject>Blood platelets</subject><subject>Blood vessels</subject><subject>Cell adhesion</subject><subject>Coatings</subject><subject>Contact angle</subject><subject>Endothelial cells</subject><subject>Fibrin</subject><subject>Fibrinogen</subject><subject>Fourier transforms</subject><subject>Hemolysis</subject><subject>Infrared spectroscopy</subject><subject>Methods</subject><subject>Morphology</subject><subject>Nylon 12</subject><subject>Paclitaxel</subject><subject>Power supply</subject><subject>Product introduction</subject><subject>Protein adsorption</subject><subject>Proteins</subject><subject>Scanning electron microscopy</subject><subject>Smooth muscle</subject><subject>Spraying</subject><subject>Stents</subject><subject>Surface chemistry</subject><subject>Tartaric acid</subject><issn>2079-6412</issn><issn>2079-6412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptUU1LAzEQDaJgqb17DHjemo_tbnKstX6AYlF7XtLsbJuS3axJCvbfG6ngB04OM3m89yaZQeickjHnklxqp6Lp1oFySmhR5kdowEgpsyKn7PhHfYpGIWxJCkm5oHKAumu_W-NnsKACYNXV-Mo47do-Ga6MNXGPXYMVXiidLuodbDZLzSDxlLXOdXjhoVc-AcuQnoDjBvDcgo7ehZhMNH7pvdrjR4gbV5-hk0bZAKOvPETLm_nr7C57eLq9n00fMs05j1mphSSKEQ7pQyUUvJBSlA0VNBdFXVAhVkwWOWGl0hNO6rwRSssJCJ0EzUrwIbo4-Pbeve0gxGrrdr5LLSsmBMtJQRn7Zq2Vhcp0jYte6dYEXU3LkqYZ8Vwm1vgfVjo1tEa7DhqT8F8CchDoNIPgoal6b1rl9xUl1ee-qr_74h8a64g8</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Yang, Xi</creator><creator>Liu, Hengquan</creator><creator>He, Junxi</creator><creator>Hu, Qiong</creator><creator>Pan, Changjiang</creator><creator>Wang, Dongfang</creator><creator>Li, Junfeng</creator><creator>Liu, Chunhai</creator><creator>Huang, Ming</creator><creator>Xiang, Qian</creator><creator>Liu, Ren</creator><general>MDPI AG</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0003-3138-8389</orcidid><orcidid>https://orcid.org/0000-0002-6733-5089</orcidid><orcidid>https://orcid.org/0009-0005-6005-3758</orcidid></search><sort><creationdate>20231001</creationdate><title>Drug Release and Biocompatibility of a Paclitaxel-Coated Balloon Prepared Using the Electrostatic Spray Method</title><author>Yang, Xi ; Liu, Hengquan ; He, Junxi ; Hu, Qiong ; Pan, Changjiang ; Wang, Dongfang ; Li, Junfeng ; Liu, Chunhai ; Huang, Ming ; Xiang, Qian ; Liu, Ren</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c333t-7c890a203e3107e6369987f181486d6188b2964027ac530d4f8ac95e8ce31fb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Additives</topic><topic>Adsorption</topic><topic>Albumin</topic><topic>Analysis</topic><topic>Antibodies</topic><topic>Anticoagulants</topic><topic>Biocompatibility</topic><topic>Blood circulation disorders</topic><topic>Blood platelets</topic><topic>Blood vessels</topic><topic>Cell adhesion</topic><topic>Coatings</topic><topic>Contact angle</topic><topic>Endothelial cells</topic><topic>Fibrin</topic><topic>Fibrinogen</topic><topic>Fourier transforms</topic><topic>Hemolysis</topic><topic>Infrared spectroscopy</topic><topic>Methods</topic><topic>Morphology</topic><topic>Nylon 12</topic><topic>Paclitaxel</topic><topic>Power supply</topic><topic>Product introduction</topic><topic>Protein adsorption</topic><topic>Proteins</topic><topic>Scanning electron microscopy</topic><topic>Smooth muscle</topic><topic>Spraying</topic><topic>Stents</topic><topic>Surface chemistry</topic><topic>Tartaric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Xi</creatorcontrib><creatorcontrib>Liu, Hengquan</creatorcontrib><creatorcontrib>He, Junxi</creatorcontrib><creatorcontrib>Hu, Qiong</creatorcontrib><creatorcontrib>Pan, Changjiang</creatorcontrib><creatorcontrib>Wang, Dongfang</creatorcontrib><creatorcontrib>Li, Junfeng</creatorcontrib><creatorcontrib>Liu, Chunhai</creatorcontrib><creatorcontrib>Huang, Ming</creatorcontrib><creatorcontrib>Xiang, Qian</creatorcontrib><creatorcontrib>Liu, Ren</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Coatings (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Xi</au><au>Liu, Hengquan</au><au>He, Junxi</au><au>Hu, Qiong</au><au>Pan, Changjiang</au><au>Wang, Dongfang</au><au>Li, Junfeng</au><au>Liu, Chunhai</au><au>Huang, Ming</au><au>Xiang, Qian</au><au>Liu, Ren</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drug Release and Biocompatibility of a Paclitaxel-Coated Balloon Prepared Using the Electrostatic Spray Method</atitle><jtitle>Coatings (Basel)</jtitle><date>2023-10-01</date><risdate>2023</risdate><volume>13</volume><issue>10</issue><spage>1674</spage><pages>1674-</pages><issn>2079-6412</issn><eissn>2079-6412</eissn><abstract>Paclitaxel-coated balloons (PCBs) have become effective treatment options for vascular disease, but long-term drug release and biocompatibility are influenced by the drug patterns. In this work, paclitaxel coatings were prepared via electrostatic spraying, and the effect of D-tartaric acid additives was investigated. Microstructures and surface morphology were studied using Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM), respectively. Drug release was measured in vitro, and biocompatibility was evaluated using the haemolysis rate, platelet adhesion and activation, protein adsorption, cell adhesion, and cell proliferation. Our results showed that a uniform crystalline paclitaxel drug coating was obtained, and that the pattern and release of paclitaxel was influenced by the content of D-tartrate. The contact angle of all coatings was less than that of nylon 12. The drug coatings prepared at a mass ratio of paclitaxel to D-tartaric acid of 2:1 had the highest drug release in a brief period of time. The haemolysis rate of the drug coating was less than 5%. Compared with the control samples, platelet adhesion and activation were significantly reduced, albumin adsorption was increased, and the adsorption of fibrinogen was reduced on the surface of the drug coating. Endothelial cells demonstrated good proliferation after three days of cell culture. Therefore, PCBs with specific patterns have good biocompatibility and drug release, with potential clinical applications in vascular disease.</abstract><cop>Basel</cop><pub>MDPI AG</pub><doi>10.3390/coatings13101674</doi><orcidid>https://orcid.org/0000-0003-3138-8389</orcidid><orcidid>https://orcid.org/0000-0002-6733-5089</orcidid><orcidid>https://orcid.org/0009-0005-6005-3758</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Additives Adsorption Albumin Analysis Antibodies Anticoagulants Biocompatibility Blood circulation disorders Blood platelets Blood vessels Cell adhesion Coatings Contact angle Endothelial cells Fibrin Fibrinogen Fourier transforms Hemolysis Infrared spectroscopy Methods Morphology Nylon 12 Paclitaxel Power supply Product introduction Protein adsorption Proteins Scanning electron microscopy Smooth muscle Spraying Stents Surface chemistry Tartaric acid |
title | Drug Release and Biocompatibility of a Paclitaxel-Coated Balloon Prepared Using the Electrostatic Spray Method |
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