Advances in research of ursolic acid and its derivatives as potential drug candidates against various types of lung cancers
As one of the most common mortal diseases, the development of anti-lung cancer drugs is never stopped. Ursolic acid (UA) is a pentacyclic triterpenoid with significant anti-lung cancer activity and low toxicity. The bottleneck of UA in clinical application is poor water solubility and bioavailabilit...
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| Veröffentlicht in: | Medicinal chemistry research 2023-11, Vol.32 (11), p.2279-2298 |
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| container_title | Medicinal chemistry research |
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| creator | Song, Li Dai, Ling Tan, Yan Jiang, Kailin Wei, Xueni Hu, Yufei Hu, Yalin Lin, Jieying Yao, Xu Mi, Pengbing Zheng, Xing |
| description | As one of the most common mortal diseases, the development of anti-lung cancer drugs is never stopped. Ursolic acid (UA) is a pentacyclic triterpenoid with significant anti-lung cancer activity and low toxicity. The bottleneck of UA in clinical application is poor water solubility and bioavailability. Until now, many novel UA derivatives have been developed to overtake these problems. In this paper, the relationship between the structure and activity of different functional groups was discussed. All anti-lung cancer ursolic acid derivatives were reviewed, and their biological activity and structure–activity relationship were described. The research progress of UA derivatives against various types of lung cancer was reviewed. |
| doi_str_mv | 10.1007/s00044-023-03147-2 |
| format | Article |
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| subjects | Bioavailability Biochemistry Biological activity Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Drug development Functional groups Inorganic Chemistry Lung cancer Medicinal Chemistry Pharmacology/Toxicology Review Article Toxicity Ursolic acid |
| title | Advances in research of ursolic acid and its derivatives as potential drug candidates against various types of lung cancers |
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