Progression of pancreatic branch duct-type intraductal papillary mucinous neoplasms (BD-IPMNs) after surgery for extrapancreatic malignancies
Background/aims The natural history of pancreatic branch duct-type intraductal papillary mucinous neoplasms (BD-IPMNs) is still unknown. This retrospective study aims to determine the morphological changes of BD-IPMNs with attention to the history of surgical resection for extrapancreatic malignanci...
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| Veröffentlicht in: | Egyptian Liver Journal 2023-12, Vol.13 (1), p.58-6, Article 58 |
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| creator | Imoto, Akira Ogura, Takeshi Masuda, Daisuke Narabayashi, Ken Okada, Toshihiko Abe, Yosuke Takeuchi, Toshihisa Inoue, Takuya Ishida, Kumi Nouda, Sadaharu Higuchi, Kazuhide Abdelaal, Usama M. |
| description | Background/aims
The natural history of pancreatic branch duct-type intraductal papillary mucinous neoplasms (BD-IPMNs) is still unknown. This retrospective study aims to determine the morphological changes of BD-IPMNs with attention to the history of surgical resection for extrapancreatic malignancies.
Methods and materials
This study included 427 subjects with BD-IPMN at the Osaka Medical College from January 2001 to December 2019; 134 patients were included. The predictive factors for the progression of BD-IPMN based on morphological changes were evaluated by univariate as well as multivariate analyses. Furthermore, the clinical features of BD-IPMNs with progressive lesions during follow-up were investigated.
Results
The average interval of follow-up was 35.8 months (with a range between 12.1 and 157 months). Disease progression occurred in 6 subjects (4.5%). In two of them (1.5%), IPMN-related invasive carcinoma was found. Multivariate analysis demonstrated that surgical resection for extrapancreatic malignancies was a significant predictor of BD-IPMN progression.
Conclusion
The history of resection of extrapancreatic malignancies should be considered during the follow-up of BD-IPMN. |
| doi_str_mv | 10.1186/s43066-023-00286-4 |
| format | Article |
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The natural history of pancreatic branch duct-type intraductal papillary mucinous neoplasms (BD-IPMNs) is still unknown. This retrospective study aims to determine the morphological changes of BD-IPMNs with attention to the history of surgical resection for extrapancreatic malignancies.
Methods and materials
This study included 427 subjects with BD-IPMN at the Osaka Medical College from January 2001 to December 2019; 134 patients were included. The predictive factors for the progression of BD-IPMN based on morphological changes were evaluated by univariate as well as multivariate analyses. Furthermore, the clinical features of BD-IPMNs with progressive lesions during follow-up were investigated.
Results
The average interval of follow-up was 35.8 months (with a range between 12.1 and 157 months). Disease progression occurred in 6 subjects (4.5%). In two of them (1.5%), IPMN-related invasive carcinoma was found. Multivariate analysis demonstrated that surgical resection for extrapancreatic malignancies was a significant predictor of BD-IPMN progression.
Conclusion
The history of resection of extrapancreatic malignancies should be considered during the follow-up of BD-IPMN.</description><identifier>ISSN: 2090-6226</identifier><identifier>ISSN: 2090-6218</identifier><identifier>EISSN: 2090-6226</identifier><identifier>DOI: 10.1186/s43066-023-00286-4</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Antigens ; Branch duct type ; Breast cancer ; Carbohydrates ; Colorectal cancer ; Cysts ; Development and progression ; Diabetes ; Endoscopy ; Epidemiology ; Extrapancreatic malignancy ; Gastric cancer ; Hepatology ; Intraductal papillary mucinous neoplasm ; Liver cancer ; Lung cancer ; Magnetic resonance imaging ; Medical colleges ; Medicine ; Medicine & Public Health ; Microbiology ; Morphology ; Original Research Article ; Pathology ; Progression after surgery ; Statistical analysis ; Surgery ; Surgical stress ; Tumors ; Virology</subject><ispartof>Egyptian Liver Journal, 2023-12, Vol.13 (1), p.58-6, Article 58</ispartof><rights>The Author(s) 2023</rights><rights>COPYRIGHT 2023 Springer</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c447t-827a1d38ea3bbf90b780c646ae0e7d12f523f1c43065c972fed94167ef3fd6023</cites><orcidid>0000-0001-9998-668X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids></links><search><creatorcontrib>Imoto, Akira</creatorcontrib><creatorcontrib>Ogura, Takeshi</creatorcontrib><creatorcontrib>Masuda, Daisuke</creatorcontrib><creatorcontrib>Narabayashi, Ken</creatorcontrib><creatorcontrib>Okada, Toshihiko</creatorcontrib><creatorcontrib>Abe, Yosuke</creatorcontrib><creatorcontrib>Takeuchi, Toshihisa</creatorcontrib><creatorcontrib>Inoue, Takuya</creatorcontrib><creatorcontrib>Ishida, Kumi</creatorcontrib><creatorcontrib>Nouda, Sadaharu</creatorcontrib><creatorcontrib>Higuchi, Kazuhide</creatorcontrib><creatorcontrib>Abdelaal, Usama M.</creatorcontrib><title>Progression of pancreatic branch duct-type intraductal papillary mucinous neoplasms (BD-IPMNs) after surgery for extrapancreatic malignancies</title><title>Egyptian Liver Journal</title><addtitle>Egypt Liver Journal</addtitle><description>Background/aims
The natural history of pancreatic branch duct-type intraductal papillary mucinous neoplasms (BD-IPMNs) is still unknown. This retrospective study aims to determine the morphological changes of BD-IPMNs with attention to the history of surgical resection for extrapancreatic malignancies.
Methods and materials
This study included 427 subjects with BD-IPMN at the Osaka Medical College from January 2001 to December 2019; 134 patients were included. The predictive factors for the progression of BD-IPMN based on morphological changes were evaluated by univariate as well as multivariate analyses. Furthermore, the clinical features of BD-IPMNs with progressive lesions during follow-up were investigated.
Results
The average interval of follow-up was 35.8 months (with a range between 12.1 and 157 months). Disease progression occurred in 6 subjects (4.5%). In two of them (1.5%), IPMN-related invasive carcinoma was found. Multivariate analysis demonstrated that surgical resection for extrapancreatic malignancies was a significant predictor of BD-IPMN progression.
Conclusion
The history of resection of extrapancreatic malignancies should be considered during the follow-up of BD-IPMN.</description><subject>Antigens</subject><subject>Branch duct type</subject><subject>Breast cancer</subject><subject>Carbohydrates</subject><subject>Colorectal cancer</subject><subject>Cysts</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Endoscopy</subject><subject>Epidemiology</subject><subject>Extrapancreatic malignancy</subject><subject>Gastric cancer</subject><subject>Hepatology</subject><subject>Intraductal papillary mucinous neoplasm</subject><subject>Liver cancer</subject><subject>Lung cancer</subject><subject>Magnetic resonance imaging</subject><subject>Medical colleges</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microbiology</subject><subject>Morphology</subject><subject>Original Research Article</subject><subject>Pathology</subject><subject>Progression after surgery</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Surgical stress</subject><subject>Tumors</subject><subject>Virology</subject><issn>2090-6226</issn><issn>2090-6218</issn><issn>2090-6226</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNp9Ustu1TAQjRBIVKU_wMoSG1ik-HVtZ1nK60oFuoC15euML75K7GAnUvsR_DNzG0SLhLAXnhmdc-bhaZrnjJ4zZtTrKgVVqqVctJRyo1r5qDnhtKOt4lw9fmA_bc5qPVA8hmkq9Enz87rkfYFaY04kBzK55Au4OXqyK2h_J_3i53a-nYDENBd3dN2AuCkOgyu3ZFx8THmpJEGeBlfHSl6-edturz99rq-ICzMUUpeyB8SGXAjcoMqDNKMb4j6hH6E-a54EN1Q4-_2eNt_ev_t6-bG9-vJhe3lx1Xop9dwarh3rhQEndrvQ0Z021CupHFDQPeNhw0Vg_jiWje80D9B3kikNQYRe4ZxOm-2q22d3sFOJI3Zis4v2LpDL3rqCxQ1gtQkgheJgjJRgeId6BrNyLxxlnUGtF6vWVPKPBepsD3kpCcu33Bi2kZtO0HvU3qFoTCHjFPwYq7cXGr-CU8MVos7_gcLbwxh9ThAixv8i8JXgS661QPjTDKP2uBx2XQ6LTdu75bASSWIlVQQn_Jj7iv_D-gXUbLyX</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Imoto, Akira</creator><creator>Ogura, Takeshi</creator><creator>Masuda, Daisuke</creator><creator>Narabayashi, Ken</creator><creator>Okada, Toshihiko</creator><creator>Abe, Yosuke</creator><creator>Takeuchi, Toshihisa</creator><creator>Inoue, Takuya</creator><creator>Ishida, Kumi</creator><creator>Nouda, Sadaharu</creator><creator>Higuchi, Kazuhide</creator><creator>Abdelaal, Usama M.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-9998-668X</orcidid></search><sort><creationdate>20231201</creationdate><title>Progression of pancreatic branch duct-type intraductal papillary mucinous neoplasms (BD-IPMNs) after surgery for extrapancreatic malignancies</title><author>Imoto, Akira ; Ogura, Takeshi ; Masuda, Daisuke ; Narabayashi, Ken ; Okada, Toshihiko ; Abe, Yosuke ; Takeuchi, Toshihisa ; Inoue, Takuya ; Ishida, Kumi ; Nouda, Sadaharu ; Higuchi, Kazuhide ; Abdelaal, Usama M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-827a1d38ea3bbf90b780c646ae0e7d12f523f1c43065c972fed94167ef3fd6023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antigens</topic><topic>Branch duct type</topic><topic>Breast cancer</topic><topic>Carbohydrates</topic><topic>Colorectal cancer</topic><topic>Cysts</topic><topic>Development and progression</topic><topic>Diabetes</topic><topic>Endoscopy</topic><topic>Epidemiology</topic><topic>Extrapancreatic malignancy</topic><topic>Gastric cancer</topic><topic>Hepatology</topic><topic>Intraductal papillary mucinous neoplasm</topic><topic>Liver cancer</topic><topic>Lung cancer</topic><topic>Magnetic resonance imaging</topic><topic>Medical colleges</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microbiology</topic><topic>Morphology</topic><topic>Original Research Article</topic><topic>Pathology</topic><topic>Progression after surgery</topic><topic>Statistical analysis</topic><topic>Surgery</topic><topic>Surgical stress</topic><topic>Tumors</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Imoto, Akira</creatorcontrib><creatorcontrib>Ogura, Takeshi</creatorcontrib><creatorcontrib>Masuda, Daisuke</creatorcontrib><creatorcontrib>Narabayashi, Ken</creatorcontrib><creatorcontrib>Okada, Toshihiko</creatorcontrib><creatorcontrib>Abe, Yosuke</creatorcontrib><creatorcontrib>Takeuchi, Toshihisa</creatorcontrib><creatorcontrib>Inoue, Takuya</creatorcontrib><creatorcontrib>Ishida, Kumi</creatorcontrib><creatorcontrib>Nouda, Sadaharu</creatorcontrib><creatorcontrib>Higuchi, Kazuhide</creatorcontrib><creatorcontrib>Abdelaal, Usama M.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Egyptian Liver Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Imoto, Akira</au><au>Ogura, Takeshi</au><au>Masuda, Daisuke</au><au>Narabayashi, Ken</au><au>Okada, Toshihiko</au><au>Abe, Yosuke</au><au>Takeuchi, Toshihisa</au><au>Inoue, Takuya</au><au>Ishida, Kumi</au><au>Nouda, Sadaharu</au><au>Higuchi, Kazuhide</au><au>Abdelaal, Usama M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progression of pancreatic branch duct-type intraductal papillary mucinous neoplasms (BD-IPMNs) after surgery for extrapancreatic malignancies</atitle><jtitle>Egyptian Liver Journal</jtitle><stitle>Egypt Liver Journal</stitle><date>2023-12-01</date><risdate>2023</risdate><volume>13</volume><issue>1</issue><spage>58</spage><epage>6</epage><pages>58-6</pages><artnum>58</artnum><issn>2090-6226</issn><issn>2090-6218</issn><eissn>2090-6226</eissn><abstract>Background/aims
The natural history of pancreatic branch duct-type intraductal papillary mucinous neoplasms (BD-IPMNs) is still unknown. This retrospective study aims to determine the morphological changes of BD-IPMNs with attention to the history of surgical resection for extrapancreatic malignancies.
Methods and materials
This study included 427 subjects with BD-IPMN at the Osaka Medical College from January 2001 to December 2019; 134 patients were included. The predictive factors for the progression of BD-IPMN based on morphological changes were evaluated by univariate as well as multivariate analyses. Furthermore, the clinical features of BD-IPMNs with progressive lesions during follow-up were investigated.
Results
The average interval of follow-up was 35.8 months (with a range between 12.1 and 157 months). Disease progression occurred in 6 subjects (4.5%). In two of them (1.5%), IPMN-related invasive carcinoma was found. Multivariate analysis demonstrated that surgical resection for extrapancreatic malignancies was a significant predictor of BD-IPMN progression.
Conclusion
The history of resection of extrapancreatic malignancies should be considered during the follow-up of BD-IPMN.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43066-023-00286-4</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-9998-668X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antigens Branch duct type Breast cancer Carbohydrates Colorectal cancer Cysts Development and progression Diabetes Endoscopy Epidemiology Extrapancreatic malignancy Gastric cancer Hepatology Intraductal papillary mucinous neoplasm Liver cancer Lung cancer Magnetic resonance imaging Medical colleges Medicine Medicine & Public Health Microbiology Morphology Original Research Article Pathology Progression after surgery Statistical analysis Surgery Surgical stress Tumors Virology |
| title | Progression of pancreatic branch duct-type intraductal papillary mucinous neoplasms (BD-IPMNs) after surgery for extrapancreatic malignancies |
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