Efficient, multi-hundred-gram scale access to E3 ubiquitin ligase ligands for degrader development

Small molecule heterobifunctional degraders (commonly also known as PROTACs) offer tremendous potential to deliver new therapeutics in areas of unmet medical need. To deliver on this promise, a new discipline directed at degrader design and optimization has emerged within medicinal chemistry to addr...

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Veröffentlicht in:	Organic & biomolecular chemistry 2023-10, Vol.21 (41), p.8344-8352
Hauptverfasser:	Cooper, Mark S, Norley, Mark C, Armitage, Simon, Cresser-Brown, Joel O, Edmonds, Anthony K, Goggins, Sean, Hopewell, Jonathan P, Karadogan, Burhan, Knights, Kevin A, Nash, Toby J, Oakes, Catherine S, O'Neill, William J, Pridmore, Simon J, Maple, Hannah J, Marsh, Graham P
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical compounds Commonality Degradation Design optimization Ligands Research programs Ubiquitin-protein ligase
Online-Zugang:	Volltext
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