Bacterial SEAL domains undergo autoproteolysis and function in regulated intramembrane proteolysis

Gram-positive bacteria use SigI/RsgI-family sigma factor/anti-sigma factor pairs to sense and respond to cell wall defects and plant polysaccharides. In Bacillus subtilis, this signal transduction pathway involves regulated intramembrane proteolysis (RIP) of the membrane-anchored anti-sigma factor R...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-10, Vol.120 (40)
Hauptverfasser:	Brogan, Anna P, Habib, Cameron, Hobbs, Samuel J, Kranzusch, Philip J, Rudner, David Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Cell walls Cleavage Gram-positive bacteria Mechanotransduction Membranes Polysaccharides Protease Proteolysis Saccharides Sigma factor Signal transduction Structure-function relationships
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