Label-free analysis of membrane protein binding kinetics and cell adhesions using evanescent scattering microscopy

Measuring ligand interactions with membrane proteins in single live cells is critical for understanding many cellular processes and screening drugs. However, developing such a capability has been a difficult challenge. Here, we employ evanescent scattering microscopy (ESM) to show that ligand bindin...

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Veröffentlicht in:	Analyst (London) 2023-10, Vol.148 (2), p.584-593
Hauptverfasser:	Xu, Jiying, Huang, Caixin, Li, Liangju, Zhao, Ying, Guo, Zhenpeng, Chen, Yi, Zhang, Pengfei
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Cell adhesion Cell adhesion & migration Kinetics Labels Ligands Membranes Microscopy Molecular interactions Proteins Scattering
Online-Zugang:	Volltext
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