Inside Back Cover: Prolinyl Nucleotides Drive Enzyme‐Free Genetic Copying of RNA (Angew. Chem. Int. Ed. 41/2023)

A new synergy between fundamental classes of biomolecules is reported by Clemens Richert et al. in their Research Article (e202307591). Prolinyl nucleotides, such as the one shown in the upper right‐hand corner of the image, act as building blocks in the enzyme‐free genetic copying of RNA. The cycli...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie International Edition 2023-10, Vol.62 (41)
Hauptverfasser:	Welsch, Franziska, Kervio, Eric, Tremmel, Peter, Richert, Clemens
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Biomolecules Copying Nucleotides Phosphodiesters Ribonucleic acid RNA
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page
container_issue	41
container_start_page
container_title	Angewandte Chemie International Edition
container_volume	62
creator	Welsch, Franziska Kervio, Eric Tremmel, Peter Richert, Clemens
description	A new synergy between fundamental classes of biomolecules is reported by Clemens Richert et al. in their Research Article (e202307591). Prolinyl nucleotides, such as the one shown in the upper right‐hand corner of the image, act as building blocks in the enzyme‐free genetic copying of RNA. The cyclic amino acid is the leaving group when new phosphodiesters are formed on the RNA template, as shown in the growing duplex in the center. That a proteinogenic amino acid can replace the pyrophosphate of polymerase‐driven replication processes of extant biology helps to fill a gap in our understanding of the molecular origin of life.
doi_str_mv	10.1002/anie.202310361
format	Article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2871554949</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2871554949</sourcerecordid><originalsourceid>FETCH-LOGICAL-c192t-5a10969af093cc867c39f43dfe7bfc32143e921212244002896a1fe29782299c3</originalsourceid><addsrcrecordid>eNo9kMtOwzAQRS0EEqWwZW2JDSyS-pGX2ZXQlkpVQQjWUXDHJSW1i50WhRWfwDfyJTgqQrOYkebM416EzikJKSFsUOoKQkYYp4Qn9AD1aMxowNOUH_o64jxIs5geoxPnVp7PMpL0kJ1qVy0A35TyDedmB_YaP1hTV7qt8XwrazCN7zt8a6sd4JH-bNfw8_U9tgB4AhqaSvq5TVvpJTYKP86H-HKol_AR4vwV1iGe6ibEo0WIIzrovrs6RUeqrB2c_eU-eh6PnvK7YHY_mebDWSCpYE0Ql5SIRJSKCC5llqSSCxXxhYL0RUnOvCIQjPpgUdTpEUlJFTCRZowJIXkfXez3bqx534JripXZWu1PFixLaRxHIhKeCveUtMY5C6rY2Gpd2ragpOh8LTpfi39f-S81sWfW</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2871554949</pqid></control><display><type>article</type><title>Inside Back Cover: Prolinyl Nucleotides Drive Enzyme‐Free Genetic Copying of RNA (Angew. Chem. Int. Ed. 41/2023)</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Welsch, Franziska ; Kervio, Eric ; Tremmel, Peter ; Richert, Clemens</creator><creatorcontrib>Welsch, Franziska ; Kervio, Eric ; Tremmel, Peter ; Richert, Clemens</creatorcontrib><description>A new synergy between fundamental classes of biomolecules is reported by Clemens Richert et al. in their Research Article (e202307591). Prolinyl nucleotides, such as the one shown in the upper right‐hand corner of the image, act as building blocks in the enzyme‐free genetic copying of RNA. The cyclic amino acid is the leaving group when new phosphodiesters are formed on the RNA template, as shown in the growing duplex in the center. That a proteinogenic amino acid can replace the pyrophosphate of polymerase‐driven replication processes of extant biology helps to fill a gap in our understanding of the molecular origin of life.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.202310361</identifier><language>eng</language><publisher>Weinheim: Wiley Subscription Services, Inc</publisher><subject>Amino acids ; Biomolecules ; Copying ; Nucleotides ; Phosphodiesters ; Ribonucleic acid ; RNA</subject><ispartof>Angewandte Chemie International Edition, 2023-10, Vol.62 (41)</ispartof><rights>2023 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-6907-0205</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Welsch, Franziska</creatorcontrib><creatorcontrib>Kervio, Eric</creatorcontrib><creatorcontrib>Tremmel, Peter</creatorcontrib><creatorcontrib>Richert, Clemens</creatorcontrib><title>Inside Back Cover: Prolinyl Nucleotides Drive Enzyme‐Free Genetic Copying of RNA (Angew. Chem. Int. Ed. 41/2023)</title><title>Angewandte Chemie International Edition</title><description>A new synergy between fundamental classes of biomolecules is reported by Clemens Richert et al. in their Research Article (e202307591). Prolinyl nucleotides, such as the one shown in the upper right‐hand corner of the image, act as building blocks in the enzyme‐free genetic copying of RNA. The cyclic amino acid is the leaving group when new phosphodiesters are formed on the RNA template, as shown in the growing duplex in the center. That a proteinogenic amino acid can replace the pyrophosphate of polymerase‐driven replication processes of extant biology helps to fill a gap in our understanding of the molecular origin of life.</description><subject>Amino acids</subject><subject>Biomolecules</subject><subject>Copying</subject><subject>Nucleotides</subject><subject>Phosphodiesters</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNo9kMtOwzAQRS0EEqWwZW2JDSyS-pGX2ZXQlkpVQQjWUXDHJSW1i50WhRWfwDfyJTgqQrOYkebM416EzikJKSFsUOoKQkYYp4Qn9AD1aMxowNOUH_o64jxIs5geoxPnVp7PMpL0kJ1qVy0A35TyDedmB_YaP1hTV7qt8XwrazCN7zt8a6sd4JH-bNfw8_U9tgB4AhqaSvq5TVvpJTYKP86H-HKol_AR4vwV1iGe6ibEo0WIIzrovrs6RUeqrB2c_eU-eh6PnvK7YHY_mebDWSCpYE0Ql5SIRJSKCC5llqSSCxXxhYL0RUnOvCIQjPpgUdTpEUlJFTCRZowJIXkfXez3bqx534JripXZWu1PFixLaRxHIhKeCveUtMY5C6rY2Gpd2ragpOh8LTpfi39f-S81sWfW</recordid><startdate>20231009</startdate><enddate>20231009</enddate><creator>Welsch, Franziska</creator><creator>Kervio, Eric</creator><creator>Tremmel, Peter</creator><creator>Richert, Clemens</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0002-6907-0205</orcidid></search><sort><creationdate>20231009</creationdate><title>Inside Back Cover: Prolinyl Nucleotides Drive Enzyme‐Free Genetic Copying of RNA (Angew. Chem. Int. Ed. 41/2023)</title><author>Welsch, Franziska ; Kervio, Eric ; Tremmel, Peter ; Richert, Clemens</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c192t-5a10969af093cc867c39f43dfe7bfc32143e921212244002896a1fe29782299c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Amino acids</topic><topic>Biomolecules</topic><topic>Copying</topic><topic>Nucleotides</topic><topic>Phosphodiesters</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Welsch, Franziska</creatorcontrib><creatorcontrib>Kervio, Eric</creatorcontrib><creatorcontrib>Tremmel, Peter</creatorcontrib><creatorcontrib>Richert, Clemens</creatorcontrib><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Welsch, Franziska</au><au>Kervio, Eric</au><au>Tremmel, Peter</au><au>Richert, Clemens</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inside Back Cover: Prolinyl Nucleotides Drive Enzyme‐Free Genetic Copying of RNA (Angew. Chem. Int. Ed. 41/2023)</atitle><jtitle>Angewandte Chemie International Edition</jtitle><date>2023-10-09</date><risdate>2023</risdate><volume>62</volume><issue>41</issue><issn>1433-7851</issn><eissn>1521-3773</eissn><abstract>A new synergy between fundamental classes of biomolecules is reported by Clemens Richert et al. in their Research Article (e202307591). Prolinyl nucleotides, such as the one shown in the upper right‐hand corner of the image, act as building blocks in the enzyme‐free genetic copying of RNA. The cyclic amino acid is the leaving group when new phosphodiesters are formed on the RNA template, as shown in the growing duplex in the center. That a proteinogenic amino acid can replace the pyrophosphate of polymerase‐driven replication processes of extant biology helps to fill a gap in our understanding of the molecular origin of life.</abstract><cop>Weinheim</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/anie.202310361</doi><edition>International ed. in English</edition><orcidid>https://orcid.org/0000-0002-6907-0205</orcidid><oa>free_for_read</oa></addata></record>
fulltext	fulltext
identifier	ISSN: 1433-7851
ispartof	Angewandte Chemie International Edition, 2023-10, Vol.62 (41)
issn	1433-7851 1521-3773
language	eng
recordid	cdi_proquest_journals_2871554949
source	Wiley Online Library Journals Frontfile Complete
subjects	Amino acids Biomolecules Copying Nucleotides Phosphodiesters Ribonucleic acid RNA
title	Inside Back Cover: Prolinyl Nucleotides Drive Enzyme‐Free Genetic Copying of RNA (Angew. Chem. Int. Ed. 41/2023)
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T00%3A46%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inside%20Back%20Cover:%20Prolinyl%20Nucleotides%20Drive%20Enzyme%E2%80%90Free%20Genetic%20Copying%20of%20RNA%20(Angew.%20Chem.%20Int.%20Ed.%2041/2023)&rft.jtitle=Angewandte%20Chemie%20International%20Edition&rft.au=Welsch,%20Franziska&rft.date=2023-10-09&rft.volume=62&rft.issue=41&rft.issn=1433-7851&rft.eissn=1521-3773&rft_id=info:doi/10.1002/anie.202310361&rft_dat=%3Cproquest_cross%3E2871554949%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2871554949&rft_id=info:pmid/&rfr_iscdi=true