Glycolipotripeptide (N-Lactitol-Gly)2-LysC16 and Its Fluorescently Labeled Analog for Visualizing Vector Systems for the Delivery of Biologically Active Substances to Target Cells
This paper studies the preparation of a carbohydrate derivative of lipotripeptide ( N -lactitol-Gly) 2 -LysC 16 of an irregular structure with two terminal residues of D-galactose, a branching link based on aliphatic L-lysine and its carbohydrate-free analog with 1-pyrenbutanol as a fluorescent labe...
Gespeichert in:
| Veröffentlicht in: | Moscow University chemistry bulletin 2023-10, Vol.78 (5), p.283-291 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 291 |
|---|---|
| container_issue | 5 |
| container_start_page | 283 |
| container_title | Moscow University chemistry bulletin |
| container_volume | 78 |
| creator | Afanasyeva, K. A. Gileva, A. M. Markvicheva, E. A. Budanova, U. A. Sebyakin, Y. L. |
| description | This paper studies the preparation of a carbohydrate derivative of lipotripeptide (
N
-lactitol-Gly)
2
-LysC
16
of an irregular structure with two terminal residues of D-galactose, a branching link based on aliphatic L-lysine and its carbohydrate-free analog with 1-pyrenbutanol as a fluorescent label in a hydrophobic fragment. The developed synthesis scheme includes universal approaches of peptide chemistry and the stages of the formation of an acyclic carbohydrate based on lactose in the hydrophilic domain of amphiphile. The compounds are designed to create compositions of the vector BAS delivery systems with the ability to visualize the process of interaction with the target cells. |
| doi_str_mv | 10.3103/S0027131423050036 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2871277863</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2871277863</sourcerecordid><originalsourceid>FETCH-LOGICAL-c268t-f8a97e6c886750470038c3167efdc516d962f9c63947e9b007974e28e247be803</originalsourceid><addsrcrecordid>eNp1kc9u1DAQxi0EEkvhAbhZ4gKHgP8ktnNcFloqRXDY0mvkdSaLKzcOHqdSeC1eEC-LxAFxGml-3_eNZoaQl5y9lZzJd3vGhOaS10KyhjGpHpENb2VTMaHYY7I54erEn5JniHeMNUpIvSE_r8LqYvBzzMnPMGc_AH39ueqsyz7HUBX-RlTdijuuqJ0Gep2RXoYlJkAHUw4r7ewBAgx0O9kQj3SMid56XGzwP_x0pLfgcmntV8xwj79x_gb0AwT_AGmlcaTvfSxO72wocdsy-QHofjlgtpMDpDnSG5uOkOkOQsDn5MloA8KLP_WCfL38eLP7VHVfrq53265yQplcjca2GpQzRumG1bpcxTjJlYZxcA1XQ6vE2Dol21pDe2BMt7oGYUDU-gCGyQvy6pw7p_h9Acz9XVxSWRJ7YTQXWhsli4qfVS5FxARjPyd_b9Pac9afftP_85viEWcPFu10hPQ3-f-mX0L8kZI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2871277863</pqid></control><display><type>article</type><title>Glycolipotripeptide (N-Lactitol-Gly)2-LysC16 and Its Fluorescently Labeled Analog for Visualizing Vector Systems for the Delivery of Biologically Active Substances to Target Cells</title><source>SpringerLink Journals - AutoHoldings</source><creator>Afanasyeva, K. A. ; Gileva, A. M. ; Markvicheva, E. A. ; Budanova, U. A. ; Sebyakin, Y. L.</creator><creatorcontrib>Afanasyeva, K. A. ; Gileva, A. M. ; Markvicheva, E. A. ; Budanova, U. A. ; Sebyakin, Y. L.</creatorcontrib><description>This paper studies the preparation of a carbohydrate derivative of lipotripeptide (
N
-lactitol-Gly)
2
-LysC
16
of an irregular structure with two terminal residues of D-galactose, a branching link based on aliphatic L-lysine and its carbohydrate-free analog with 1-pyrenbutanol as a fluorescent label in a hydrophobic fragment. The developed synthesis scheme includes universal approaches of peptide chemistry and the stages of the formation of an acyclic carbohydrate based on lactose in the hydrophilic domain of amphiphile. The compounds are designed to create compositions of the vector BAS delivery systems with the ability to visualize the process of interaction with the target cells.</description><identifier>ISSN: 0027-1314</identifier><identifier>EISSN: 1935-0260</identifier><identifier>DOI: 10.3103/S0027131423050036</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Carbohydrates ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Fluorescence ; Galactose ; Lactose ; Lysine ; Original Article</subject><ispartof>Moscow University chemistry bulletin, 2023-10, Vol.78 (5), p.283-291</ispartof><rights>Allerton Press, Inc. 2023. ISSN 0027-1314, Moscow University Chemistry Bulletin, 2023, Vol. 78, No. 5, pp. 283–291. © Allerton Press, Inc., 2023. Russian Text © The Author(s), 2023, published in Vestnik Moskovskogo Universiteta, Seriya 2: Khimiya, 2023, No. 5, pp. 478–489.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c268t-f8a97e6c886750470038c3167efdc516d962f9c63947e9b007974e28e247be803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.3103/S0027131423050036$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.3103/S0027131423050036$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids></links><search><creatorcontrib>Afanasyeva, K. A.</creatorcontrib><creatorcontrib>Gileva, A. M.</creatorcontrib><creatorcontrib>Markvicheva, E. A.</creatorcontrib><creatorcontrib>Budanova, U. A.</creatorcontrib><creatorcontrib>Sebyakin, Y. L.</creatorcontrib><title>Glycolipotripeptide (N-Lactitol-Gly)2-LysC16 and Its Fluorescently Labeled Analog for Visualizing Vector Systems for the Delivery of Biologically Active Substances to Target Cells</title><title>Moscow University chemistry bulletin</title><addtitle>Moscow Univ. Chem. Bull</addtitle><description>This paper studies the preparation of a carbohydrate derivative of lipotripeptide (
N
-lactitol-Gly)
2
-LysC
16
of an irregular structure with two terminal residues of D-galactose, a branching link based on aliphatic L-lysine and its carbohydrate-free analog with 1-pyrenbutanol as a fluorescent label in a hydrophobic fragment. The developed synthesis scheme includes universal approaches of peptide chemistry and the stages of the formation of an acyclic carbohydrate based on lactose in the hydrophilic domain of amphiphile. The compounds are designed to create compositions of the vector BAS delivery systems with the ability to visualize the process of interaction with the target cells.</description><subject>Carbohydrates</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Fluorescence</subject><subject>Galactose</subject><subject>Lactose</subject><subject>Lysine</subject><subject>Original Article</subject><issn>0027-1314</issn><issn>1935-0260</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kc9u1DAQxi0EEkvhAbhZ4gKHgP8ktnNcFloqRXDY0mvkdSaLKzcOHqdSeC1eEC-LxAFxGml-3_eNZoaQl5y9lZzJd3vGhOaS10KyhjGpHpENb2VTMaHYY7I54erEn5JniHeMNUpIvSE_r8LqYvBzzMnPMGc_AH39ueqsyz7HUBX-RlTdijuuqJ0Gep2RXoYlJkAHUw4r7ewBAgx0O9kQj3SMid56XGzwP_x0pLfgcmntV8xwj79x_gb0AwT_AGmlcaTvfSxO72wocdsy-QHofjlgtpMDpDnSG5uOkOkOQsDn5MloA8KLP_WCfL38eLP7VHVfrq53265yQplcjca2GpQzRumG1bpcxTjJlYZxcA1XQ6vE2Dol21pDe2BMt7oGYUDU-gCGyQvy6pw7p_h9Acz9XVxSWRJ7YTQXWhsli4qfVS5FxARjPyd_b9Pac9afftP_85viEWcPFu10hPQ3-f-mX0L8kZI</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Afanasyeva, K. A.</creator><creator>Gileva, A. M.</creator><creator>Markvicheva, E. A.</creator><creator>Budanova, U. A.</creator><creator>Sebyakin, Y. L.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20231001</creationdate><title>Glycolipotripeptide (N-Lactitol-Gly)2-LysC16 and Its Fluorescently Labeled Analog for Visualizing Vector Systems for the Delivery of Biologically Active Substances to Target Cells</title><author>Afanasyeva, K. A. ; Gileva, A. M. ; Markvicheva, E. A. ; Budanova, U. A. ; Sebyakin, Y. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c268t-f8a97e6c886750470038c3167efdc516d962f9c63947e9b007974e28e247be803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Carbohydrates</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Fluorescence</topic><topic>Galactose</topic><topic>Lactose</topic><topic>Lysine</topic><topic>Original Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Afanasyeva, K. A.</creatorcontrib><creatorcontrib>Gileva, A. M.</creatorcontrib><creatorcontrib>Markvicheva, E. A.</creatorcontrib><creatorcontrib>Budanova, U. A.</creatorcontrib><creatorcontrib>Sebyakin, Y. L.</creatorcontrib><collection>CrossRef</collection><jtitle>Moscow University chemistry bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Afanasyeva, K. A.</au><au>Gileva, A. M.</au><au>Markvicheva, E. A.</au><au>Budanova, U. A.</au><au>Sebyakin, Y. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glycolipotripeptide (N-Lactitol-Gly)2-LysC16 and Its Fluorescently Labeled Analog for Visualizing Vector Systems for the Delivery of Biologically Active Substances to Target Cells</atitle><jtitle>Moscow University chemistry bulletin</jtitle><stitle>Moscow Univ. Chem. Bull</stitle><date>2023-10-01</date><risdate>2023</risdate><volume>78</volume><issue>5</issue><spage>283</spage><epage>291</epage><pages>283-291</pages><issn>0027-1314</issn><eissn>1935-0260</eissn><abstract>This paper studies the preparation of a carbohydrate derivative of lipotripeptide (
N
-lactitol-Gly)
2
-LysC
16
of an irregular structure with two terminal residues of D-galactose, a branching link based on aliphatic L-lysine and its carbohydrate-free analog with 1-pyrenbutanol as a fluorescent label in a hydrophobic fragment. The developed synthesis scheme includes universal approaches of peptide chemistry and the stages of the formation of an acyclic carbohydrate based on lactose in the hydrophilic domain of amphiphile. The compounds are designed to create compositions of the vector BAS delivery systems with the ability to visualize the process of interaction with the target cells.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.3103/S0027131423050036</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-1314 |
| ispartof | Moscow University chemistry bulletin, 2023-10, Vol.78 (5), p.283-291 |
| issn | 0027-1314 1935-0260 |
| language | eng |
| recordid | cdi_proquest_journals_2871277863 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Carbohydrates Chemistry Chemistry and Materials Science Chemistry/Food Science Fluorescence Galactose Lactose Lysine Original Article |
| title | Glycolipotripeptide (N-Lactitol-Gly)2-LysC16 and Its Fluorescently Labeled Analog for Visualizing Vector Systems for the Delivery of Biologically Active Substances to Target Cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T12%3A43%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Glycolipotripeptide%20(N-Lactitol-Gly)2-LysC16%20and%20Its%20Fluorescently%20Labeled%20Analog%20for%20Visualizing%20Vector%20Systems%20for%20the%20Delivery%20of%20Biologically%20Active%20Substances%20to%20Target%20Cells&rft.jtitle=Moscow%20University%20chemistry%20bulletin&rft.au=Afanasyeva,%20K.%20A.&rft.date=2023-10-01&rft.volume=78&rft.issue=5&rft.spage=283&rft.epage=291&rft.pages=283-291&rft.issn=0027-1314&rft.eissn=1935-0260&rft_id=info:doi/10.3103/S0027131423050036&rft_dat=%3Cproquest_cross%3E2871277863%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2871277863&rft_id=info:pmid/&rfr_iscdi=true |