Cytotoxic and anti-metastatic action mediates the antiproliferative activity of Rhazya stricta Decne inducing apoptotic cell death in human cancer cells: Implication in chemopreventive mechanism
Cancer is associated with a high rate of pre-mature mortality worldwide and serves as a significant impediment to extended life expectancy, leading to undesirable long-term effects on the quality of life of the patients. Bioactive chemical products derived from natural sources have an important plac...
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| Veröffentlicht in: | Emirates journal of food and agriculture 2023-01, Vol.35 (8), p.683-692 |
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| creator | Ullah, Mohammad Fahad Ahmad, Aamir Bhat, Showket H Abuduhier, Faisel M Ajmal, Mohammad Rehan Mustafa, Syed Khalid |
| description | Cancer is associated with a high rate of pre-mature mortality worldwide and serves as a significant impediment to extended life expectancy, leading to undesirable long-term effects on the quality of life of the patients. Bioactive chemical products derived from natural sources have an important place in the well-being of the human population since ancient times. Compounds derived from natural sources have dominated the drug discovery programs in the last five decades and comprise a substantial proportion of current-day pharmaceutical agents. Rhazya stricta, an evergreen shrub, it belongs to family Apocynaceae of order Gentianales, and the Rhazya stricta is known to have certain medicinal properties, as the Middle East and South Asian traditional medicine employed this plant as a cure for different diseases. Herein, the hydro-methanolic extract of Rhazya stricta Decne haa been studied for its effect on spectrum of cancer cells, including LNCaP, C4-2B, PC-3 prostate cancer cells, MDA-MB-231, MCF-7, SKBR3 breast cancer cells, A-549 lung cancer cells and BxPC-3, MiaPaCa-2 pancreatic cancer. Hydro-methanolic extract of Rhazya stricta Decne in a dose-dependent manner, showed progressive inhibition of cell growth by induction of cell death in the treated human cancer cells. The IC50 value range for different breast cancer cell lines was 1 42-1 78 |xg/ml; for prostate cancer cell lines, it was 90-1 48 |xg/ml; for pancreatic cancer cell lines 11 6-1 66 |xg/ml and for the lung cancer cells, it was reported to be 1 80 |xg/ml. The anti-metastatic potential of extract was indicated by the notable reduction in invasiveness and cell migration. Moreover, the structurally diverse phytochemical rich extract, also downregulates the signaling of NF-kB and the NF-kB downstream target cytokine VEGF, providing an insight into the anticancer action mechanism. |
| doi_str_mv | 10.9755/ejfa.2023.v35.i8.3132 |
| format | Article |
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Bioactive chemical products derived from natural sources have an important place in the well-being of the human population since ancient times. Compounds derived from natural sources have dominated the drug discovery programs in the last five decades and comprise a substantial proportion of current-day pharmaceutical agents. Rhazya stricta, an evergreen shrub, it belongs to family Apocynaceae of order Gentianales, and the Rhazya stricta is known to have certain medicinal properties, as the Middle East and South Asian traditional medicine employed this plant as a cure for different diseases. Herein, the hydro-methanolic extract of Rhazya stricta Decne haa been studied for its effect on spectrum of cancer cells, including LNCaP, C4-2B, PC-3 prostate cancer cells, MDA-MB-231, MCF-7, SKBR3 breast cancer cells, A-549 lung cancer cells and BxPC-3, MiaPaCa-2 pancreatic cancer. Hydro-methanolic extract of Rhazya stricta Decne in a dose-dependent manner, showed progressive inhibition of cell growth by induction of cell death in the treated human cancer cells. The IC50 value range for different breast cancer cell lines was 1 42-1 78 |xg/ml; for prostate cancer cell lines, it was 90-1 48 |xg/ml; for pancreatic cancer cell lines 11 6-1 66 |xg/ml and for the lung cancer cells, it was reported to be 1 80 |xg/ml. The anti-metastatic potential of extract was indicated by the notable reduction in invasiveness and cell migration. Moreover, the structurally diverse phytochemical rich extract, also downregulates the signaling of NF-kB and the NF-kB downstream target cytokine VEGF, providing an insight into the anticancer action mechanism.</description><identifier>ISSN: 2079-052X</identifier><identifier>EISSN: 2079-0538</identifier><identifier>DOI: 10.9755/ejfa.2023.v35.i8.3132</identifier><language>eng</language><publisher>Sofia: Pensoft Publishers</publisher><subject>Apoptosis ; Bioactive compounds ; Breast cancer ; Cancer therapies ; Cell culture ; Cell death ; Cell growth ; Cell migration ; Cellular biology ; Chemotherapy ; Cytotoxicity ; Human populations ; Invasiveness ; Life expectancy ; Life span ; Long-term effects ; Lung cancer ; Medical research ; Medicinal plants ; Metastases ; Metastasis ; Mortality ; NF-κB protein ; Pancreatic cancer ; Phytochemicals ; Preventive medicine ; Prostate cancer ; Quality of life ; Rhazya stricta ; Tumor cell lines ; Vascular endothelial growth factor</subject><ispartof>Emirates journal of food and agriculture, 2023-01, Vol.35 (8), p.683-692</ispartof><rights>2023. 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Bioactive chemical products derived from natural sources have an important place in the well-being of the human population since ancient times. Compounds derived from natural sources have dominated the drug discovery programs in the last five decades and comprise a substantial proportion of current-day pharmaceutical agents. Rhazya stricta, an evergreen shrub, it belongs to family Apocynaceae of order Gentianales, and the Rhazya stricta is known to have certain medicinal properties, as the Middle East and South Asian traditional medicine employed this plant as a cure for different diseases. Herein, the hydro-methanolic extract of Rhazya stricta Decne haa been studied for its effect on spectrum of cancer cells, including LNCaP, C4-2B, PC-3 prostate cancer cells, MDA-MB-231, MCF-7, SKBR3 breast cancer cells, A-549 lung cancer cells and BxPC-3, MiaPaCa-2 pancreatic cancer. Hydro-methanolic extract of Rhazya stricta Decne in a dose-dependent manner, showed progressive inhibition of cell growth by induction of cell death in the treated human cancer cells. The IC50 value range for different breast cancer cell lines was 1 42-1 78 |xg/ml; for prostate cancer cell lines, it was 90-1 48 |xg/ml; for pancreatic cancer cell lines 11 6-1 66 |xg/ml and for the lung cancer cells, it was reported to be 1 80 |xg/ml. The anti-metastatic potential of extract was indicated by the notable reduction in invasiveness and cell migration. 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and agriculture</jtitle><date>2023-01-01</date><risdate>2023</risdate><volume>35</volume><issue>8</issue><spage>683</spage><epage>692</epage><pages>683-692</pages><issn>2079-052X</issn><eissn>2079-0538</eissn><abstract>Cancer is associated with a high rate of pre-mature mortality worldwide and serves as a significant impediment to extended life expectancy, leading to undesirable long-term effects on the quality of life of the patients. Bioactive chemical products derived from natural sources have an important place in the well-being of the human population since ancient times. Compounds derived from natural sources have dominated the drug discovery programs in the last five decades and comprise a substantial proportion of current-day pharmaceutical agents. Rhazya stricta, an evergreen shrub, it belongs to family Apocynaceae of order Gentianales, and the Rhazya stricta is known to have certain medicinal properties, as the Middle East and South Asian traditional medicine employed this plant as a cure for different diseases. Herein, the hydro-methanolic extract of Rhazya stricta Decne haa been studied for its effect on spectrum of cancer cells, including LNCaP, C4-2B, PC-3 prostate cancer cells, MDA-MB-231, MCF-7, SKBR3 breast cancer cells, A-549 lung cancer cells and BxPC-3, MiaPaCa-2 pancreatic cancer. Hydro-methanolic extract of Rhazya stricta Decne in a dose-dependent manner, showed progressive inhibition of cell growth by induction of cell death in the treated human cancer cells. The IC50 value range for different breast cancer cell lines was 1 42-1 78 |xg/ml; for prostate cancer cell lines, it was 90-1 48 |xg/ml; for pancreatic cancer cell lines 11 6-1 66 |xg/ml and for the lung cancer cells, it was reported to be 1 80 |xg/ml. The anti-metastatic potential of extract was indicated by the notable reduction in invasiveness and cell migration. Moreover, the structurally diverse phytochemical rich extract, also downregulates the signaling of NF-kB and the NF-kB downstream target cytokine VEGF, providing an insight into the anticancer action mechanism.</abstract><cop>Sofia</cop><pub>Pensoft Publishers</pub><doi>10.9755/ejfa.2023.v35.i8.3132</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Apoptosis Bioactive compounds Breast cancer Cancer therapies Cell culture Cell death Cell growth Cell migration Cellular biology Chemotherapy Cytotoxicity Human populations Invasiveness Life expectancy Life span Long-term effects Lung cancer Medical research Medicinal plants Metastases Metastasis Mortality NF-κB protein Pancreatic cancer Phytochemicals Preventive medicine Prostate cancer Quality of life Rhazya stricta Tumor cell lines Vascular endothelial growth factor |
| title | Cytotoxic and anti-metastatic action mediates the antiproliferative activity of Rhazya stricta Decne inducing apoptotic cell death in human cancer cells: Implication in chemopreventive mechanism |
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