Analysis of the interplay effect in lung stereotactic ablative radiation therapy based on both breathing motion and plan characteristics
Introduction:Stereotactic ablative radiotherapy (SABR) is susceptible to challenges for tumours affected by intrafraction organ motion. This study aims to investigate the effect of breathing characteristics and plan complexity on the interplay effect.Methods:A patient-specific interplay effect evalu...
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| Veröffentlicht in: | Journal of radiotherapy in practice 2023-09, Vol.22, Article e75 |
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| creator | Ali, Asmaa M. Greenwood, Jason B. Varasteh, Mohammad Esteve, Sergio Jeevanandam, Prakash Göpfert, Fabian Irvine, Denise M. Hounsell, Alan R. McGarry, Conor K. |
| description | Introduction:Stereotactic ablative radiotherapy (SABR) is susceptible to challenges for tumours affected by intrafraction organ motion. This study aims to investigate the effect of breathing characteristics and plan complexity on the interplay effect.Methods:A patient-specific interplay effect evaluation was performed using in-house software with an alpha version of the treatment planning verification software Verisoft (PTW-Freiburg, Germany) on VMAT plans. The OCTAVIUS 4D phantom was used to acquire the static dose distribution, and the simulation approach was utilised to generate the moving dose distribution. The influence of plan complexity, PTV size, number of breaths, and motion amplitudes on the interplay effect were examined. The dose distribution of two extreme phases—end-inhale and end-exhale—was considered using the gamma criteria of 2%/2 mm for the interplay effect evaluation.Results:A strong correlation was found between the motion amplitude (p < 0.001) and the NBs (p < 0.001) with the gamma-passing rate. No correlation was found between the gamma-passing rate and the PTV size or plan complexity.Conclusion:The simulation tool allowed the analysis of a large number of breathing traces, demonstrating how free-breathing patients, suspected of high interplay, could be selected for other motion management solutions. The simulated cases showed strong interplay effects for long breathing periods with extended motion amplitudes in a small group of patients. |
| doi_str_mv | 10.1017/S146039692300033X |
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This study aims to investigate the effect of breathing characteristics and plan complexity on the interplay effect.Methods:A patient-specific interplay effect evaluation was performed using in-house software with an alpha version of the treatment planning verification software Verisoft (PTW-Freiburg, Germany) on VMAT plans. The OCTAVIUS 4D phantom was used to acquire the static dose distribution, and the simulation approach was utilised to generate the moving dose distribution. The influence of plan complexity, PTV size, number of breaths, and motion amplitudes on the interplay effect were examined. The dose distribution of two extreme phases—end-inhale and end-exhale—was considered using the gamma criteria of 2%/2 mm for the interplay effect evaluation.Results:A strong correlation was found between the motion amplitude (p < 0.001) and the NBs (p < 0.001) with the gamma-passing rate. No correlation was found between the gamma-passing rate and the PTV size or plan complexity.Conclusion:The simulation tool allowed the analysis of a large number of breathing traces, demonstrating how free-breathing patients, suspected of high interplay, could be selected for other motion management solutions. The simulated cases showed strong interplay effects for long breathing periods with extended motion amplitudes in a small group of patients.</description><identifier>ISSN: 1460-3969</identifier><identifier>EISSN: 1467-1131</identifier><identifier>DOI: 10.1017/S146039692300033X</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Ablation ; Amplitudes ; Complexity ; Dosimetry ; Original Article ; Planning ; Radiation therapy ; Respiration ; Simulation ; Software ; Tumors</subject><ispartof>Journal of radiotherapy in practice, 2023-09, Vol.22, Article e75</ispartof><rights>The Author(s), 2023. Published by Cambridge University Press</rights><rights>The Author(s), 2023. Published by Cambridge University Press. This work is licensed under the Creative Commons Attribution License This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-d663cf9c6196498fdccd58b61c06369c10fddbf1b1d824d77ede575b62de99323</citedby><cites>FETCH-LOGICAL-c360t-d663cf9c6196498fdccd58b61c06369c10fddbf1b1d824d77ede575b62de99323</cites><orcidid>0000-0001-9470-7223</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S146039692300033X/type/journal_article$$EHTML$$P50$$Gcambridge$$Hfree_for_read</linktohtml><link.rule.ids>164,314,776,780,27903,27904,55607</link.rule.ids></links><search><creatorcontrib>Ali, Asmaa M.</creatorcontrib><creatorcontrib>Greenwood, Jason B.</creatorcontrib><creatorcontrib>Varasteh, Mohammad</creatorcontrib><creatorcontrib>Esteve, Sergio</creatorcontrib><creatorcontrib>Jeevanandam, Prakash</creatorcontrib><creatorcontrib>Göpfert, Fabian</creatorcontrib><creatorcontrib>Irvine, Denise M.</creatorcontrib><creatorcontrib>Hounsell, Alan R.</creatorcontrib><creatorcontrib>McGarry, Conor K.</creatorcontrib><title>Analysis of the interplay effect in lung stereotactic ablative radiation therapy based on both breathing motion and plan characteristics</title><title>Journal of radiotherapy in practice</title><addtitle>J Radiother Pract</addtitle><description>Introduction:Stereotactic ablative radiotherapy (SABR) is susceptible to challenges for tumours affected by intrafraction organ motion. This study aims to investigate the effect of breathing characteristics and plan complexity on the interplay effect.Methods:A patient-specific interplay effect evaluation was performed using in-house software with an alpha version of the treatment planning verification software Verisoft (PTW-Freiburg, Germany) on VMAT plans. The OCTAVIUS 4D phantom was used to acquire the static dose distribution, and the simulation approach was utilised to generate the moving dose distribution. The influence of plan complexity, PTV size, number of breaths, and motion amplitudes on the interplay effect were examined. The dose distribution of two extreme phases—end-inhale and end-exhale—was considered using the gamma criteria of 2%/2 mm for the interplay effect evaluation.Results:A strong correlation was found between the motion amplitude (p < 0.001) and the NBs (p < 0.001) with the gamma-passing rate. No correlation was found between the gamma-passing rate and the PTV size or plan complexity.Conclusion:The simulation tool allowed the analysis of a large number of breathing traces, demonstrating how free-breathing patients, suspected of high interplay, could be selected for other motion management solutions. The simulated cases showed strong interplay effects for long breathing periods with extended motion amplitudes in a small group of patients.</description><subject>Ablation</subject><subject>Amplitudes</subject><subject>Complexity</subject><subject>Dosimetry</subject><subject>Original Article</subject><subject>Planning</subject><subject>Radiation therapy</subject><subject>Respiration</subject><subject>Simulation</subject><subject>Software</subject><subject>Tumors</subject><issn>1460-3969</issn><issn>1467-1131</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>IKXGN</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kMtKAzEYhYMoWKsP4C7gejSZpJnJshRvUHChgrsh107KdDImqTBv4GObXsCFuMrPyfm-xQHgGqNbjHB194opQ4QzXhKEECEfJ2CSo6rAmODT_Y2K3f85uIhxjRClFFUT8D3vRTdGF6G3MLUGuj6ZMHRihMZao1IOYLftVzDm3PgkVHIKCtmJ5L4MDEK7fPl-BwcxjFCKaDTMgfSphTIYkVqX-Y3f10SvYdb3ULUiZJkJLmZjvARnVnTRXB3fKXh_uH9bPBXLl8fnxXxZKMJQKjRjRFmuGOaM8tpqpfSslgwrxAjjCiOrtbRYYl2XVFeV0WZWzSQrteGclGQKbg7eIfjPrYmpWfttyCPEpqwZYxSTkuYWPrRU8DEGY5shuI0IY4NRsxu8-TN4ZsiRERsZnF6ZX_X_1A9IlYW7</recordid><startdate>20230921</startdate><enddate>20230921</enddate><creator>Ali, Asmaa M.</creator><creator>Greenwood, Jason B.</creator><creator>Varasteh, Mohammad</creator><creator>Esteve, Sergio</creator><creator>Jeevanandam, Prakash</creator><creator>Göpfert, Fabian</creator><creator>Irvine, Denise M.</creator><creator>Hounsell, Alan R.</creator><creator>McGarry, Conor K.</creator><general>Cambridge University Press</general><scope>IKXGN</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0001-9470-7223</orcidid></search><sort><creationdate>20230921</creationdate><title>Analysis of the interplay effect in lung stereotactic ablative radiation therapy based on both breathing motion and plan characteristics</title><author>Ali, Asmaa M. ; Greenwood, Jason B. ; Varasteh, Mohammad ; Esteve, Sergio ; Jeevanandam, Prakash ; Göpfert, Fabian ; Irvine, Denise M. ; Hounsell, Alan R. ; McGarry, Conor K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-d663cf9c6196498fdccd58b61c06369c10fddbf1b1d824d77ede575b62de99323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Ablation</topic><topic>Amplitudes</topic><topic>Complexity</topic><topic>Dosimetry</topic><topic>Original Article</topic><topic>Planning</topic><topic>Radiation therapy</topic><topic>Respiration</topic><topic>Simulation</topic><topic>Software</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ali, Asmaa M.</creatorcontrib><creatorcontrib>Greenwood, Jason B.</creatorcontrib><creatorcontrib>Varasteh, Mohammad</creatorcontrib><creatorcontrib>Esteve, Sergio</creatorcontrib><creatorcontrib>Jeevanandam, Prakash</creatorcontrib><creatorcontrib>Göpfert, Fabian</creatorcontrib><creatorcontrib>Irvine, Denise M.</creatorcontrib><creatorcontrib>Hounsell, Alan R.</creatorcontrib><creatorcontrib>McGarry, Conor K.</creatorcontrib><collection>Cambridge Journals Open Access</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Journal of radiotherapy in practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ali, Asmaa M.</au><au>Greenwood, Jason B.</au><au>Varasteh, Mohammad</au><au>Esteve, Sergio</au><au>Jeevanandam, Prakash</au><au>Göpfert, Fabian</au><au>Irvine, Denise M.</au><au>Hounsell, Alan R.</au><au>McGarry, Conor K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of the interplay effect in lung stereotactic ablative radiation therapy based on both breathing motion and plan characteristics</atitle><jtitle>Journal of radiotherapy in practice</jtitle><addtitle>J Radiother Pract</addtitle><date>2023-09-21</date><risdate>2023</risdate><volume>22</volume><artnum>e75</artnum><issn>1460-3969</issn><eissn>1467-1131</eissn><abstract>Introduction:Stereotactic ablative radiotherapy (SABR) is susceptible to challenges for tumours affected by intrafraction organ motion. This study aims to investigate the effect of breathing characteristics and plan complexity on the interplay effect.Methods:A patient-specific interplay effect evaluation was performed using in-house software with an alpha version of the treatment planning verification software Verisoft (PTW-Freiburg, Germany) on VMAT plans. The OCTAVIUS 4D phantom was used to acquire the static dose distribution, and the simulation approach was utilised to generate the moving dose distribution. The influence of plan complexity, PTV size, number of breaths, and motion amplitudes on the interplay effect were examined. The dose distribution of two extreme phases—end-inhale and end-exhale—was considered using the gamma criteria of 2%/2 mm for the interplay effect evaluation.Results:A strong correlation was found between the motion amplitude (p < 0.001) and the NBs (p < 0.001) with the gamma-passing rate. No correlation was found between the gamma-passing rate and the PTV size or plan complexity.Conclusion:The simulation tool allowed the analysis of a large number of breathing traces, demonstrating how free-breathing patients, suspected of high interplay, could be selected for other motion management solutions. The simulated cases showed strong interplay effects for long breathing periods with extended motion amplitudes in a small group of patients.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><doi>10.1017/S146039692300033X</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-9470-7223</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Ablation Amplitudes Complexity Dosimetry Original Article Planning Radiation therapy Respiration Simulation Software Tumors |
| title | Analysis of the interplay effect in lung stereotactic ablative radiation therapy based on both breathing motion and plan characteristics |
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