Pirfenidone-flavonoid cocrystals with reduced solubility and dissolution rate

Pirfenidone (PFD) is an orally administered medication used for the treatment of idiopathic pulmonary fibrosis. PFD has excessive solubility and high daily dosage. A sustained-release solid form of PFD is desired to improve the rapid absorption and elimination of this highly soluble drug, as well as...

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Veröffentlicht in:	CrystEngComm 2023-09, Vol.25 (36), p.5133-514
Hauptverfasser:	Meng, Lingshan, Li, Duanxiu, Zhu, Yujing, Wang, Jianming, Deng, Zongwu, Zhang, Hailu
Format:	Artikel
Sprache:	eng
Schlagworte:	Dissolution Fourier transforms Hydrogen bonding Infrared analysis Ketones Side effects Single crystals Solubility Thermogravimetric analysis X ray powder diffraction
Online-Zugang:	Volltext
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