Mandibular small cell osteosarcoma: a case report and review of literature
Background Small cell osteosarcoma is an extremely rare histopathological variant of conventional osteosarcoma. Due to nonspecific symptoms, most osteosarcomas of the jaws are misdiagnosed as periapical abscesses and mistreated by teeth extraction and drainage. Case presentation We report, to our kn...
Gespeichert in:
| Veröffentlicht in: | Journal of Egyptian National Cancer Institute 2023-12, Vol.35 (1), p.30-6, Article 30 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 6 |
|---|---|
| container_issue | 1 |
| container_start_page | 30 |
| container_title | Journal of Egyptian National Cancer Institute |
| container_volume | 35 |
| creator | Amer, Hatem Wael Algadi, Hana’a Hezam Hamza, Shyma’a Ahmed |
| description | Background
Small cell osteosarcoma is an extremely rare histopathological variant of conventional osteosarcoma. Due to nonspecific symptoms, most osteosarcomas of the jaws are misdiagnosed as periapical abscesses and mistreated by teeth extraction and drainage.
Case presentation
We report, to our knowledge, the seventh case of small cell osteosarcoma in gnathic sites affecting the mandible of an old female with history of a large painful swelling related to the right mandibular molar area for 2 months. Cone-beam computed tomography scan showed an osteolytic lesion related to the lower molar area with involvement of the inferior alveolar nerve. An incisional biopsy was taken, and after histopathological examination and immunohistochemical staining, a diagnosis of small cell osteosarcoma was reached. Hemi-mandibulectomy was performed by a maxillofacial surgeon. No clinical evidence for recurrence was noted until manuscript writing.
Conclusion
Accurate diagnosis is very important, and general practitioners should be aware of this entity considering that small cell osteosarcoma has a poor prognosis when compared to conventional osteosarcoma. |
| doi_str_mv | 10.1186/s43046-023-00191-2 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_proquest_journals_2865687917</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A765726068</galeid><doaj_id>oai_doaj_org_article_b7cae9901d634ccd8fb209e2e090e1bf</doaj_id><sourcerecordid>A765726068</sourcerecordid><originalsourceid>FETCH-LOGICAL-c480t-b9b2b6b47b421845f3f7614a783636542899c49798c8d33dffb523940d9773603</originalsourceid><addsrcrecordid>eNp9kV1LHTEQhpdSodb6B7xa6PXq5GPz0TuRfiiKN3odkuzkkMPu5jTZ09J_b-qKVigSmAzD-7zM8DbNCYFTQpQ4K5wBFx1Q1gEQTTr6rjmkvdIdcNDv_-k_NB9L2QIIAbI_bK5u7DxEtx9tbstkx7H1WEsqC6Zis0-T_dLa1tuCbcZdyktbgdr-ivi7TaEd44LZLvuMn5qDYMeCx0__UXP_7evdxY_u-vb75cX5dee5gqVz2lEnHJeOU6J4H1iQgnArFRNM9JwqrT3XUiuvBsaGEFxPmeYwaCmZAHbUXK6-Q7Jbs8txsvmPSTaax0HKG2PzEv2IxklvUWsgg2Dc-0EFR0EjRdCAxIXq9Xn12uX0c49lMdu0z3Nd31AleqGkJvJFtbHVNM4hLdn6KRZvzqXoJRUgVFWd_kdV34BT9GnGEOv8FUBXwOdUSsbwfAwB8zdWs8ZqaqzmMVZDK8RWqFTxvMH8svEb1AMk9aH5</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2865687917</pqid></control><display><type>article</type><title>Mandibular small cell osteosarcoma: a case report and review of literature</title><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Amer, Hatem Wael ; Algadi, Hana’a Hezam ; Hamza, Shyma’a Ahmed</creator><creatorcontrib>Amer, Hatem Wael ; Algadi, Hana’a Hezam ; Hamza, Shyma’a Ahmed</creatorcontrib><description>Background
Small cell osteosarcoma is an extremely rare histopathological variant of conventional osteosarcoma. Due to nonspecific symptoms, most osteosarcomas of the jaws are misdiagnosed as periapical abscesses and mistreated by teeth extraction and drainage.
Case presentation
We report, to our knowledge, the seventh case of small cell osteosarcoma in gnathic sites affecting the mandible of an old female with history of a large painful swelling related to the right mandibular molar area for 2 months. Cone-beam computed tomography scan showed an osteolytic lesion related to the lower molar area with involvement of the inferior alveolar nerve. An incisional biopsy was taken, and after histopathological examination and immunohistochemical staining, a diagnosis of small cell osteosarcoma was reached. Hemi-mandibulectomy was performed by a maxillofacial surgeon. No clinical evidence for recurrence was noted until manuscript writing.
Conclusion
Accurate diagnosis is very important, and general practitioners should be aware of this entity considering that small cell osteosarcoma has a poor prognosis when compared to conventional osteosarcoma.</description><identifier>ISSN: 2589-0409</identifier><identifier>ISSN: 1110-0362</identifier><identifier>EISSN: 2589-0409</identifier><identifier>DOI: 10.1186/s43046-023-00191-2</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biopsy ; Bone cancer ; Bone tumors ; Bones ; Case report ; Case Reports ; Cells ; Chemotherapy ; Cytoplasm ; Ewings sarcoma ; Immunohistochemistry ; Jaw ; Jaws neoplasms ; Lymphoma ; Mandibular osteosarcoma ; Medicine ; Medicine & Public Health ; Metastasis ; Oncology ; Osteosarcoma ; Proteins ; Radiation therapy ; Sarcoma ; Small cell osteosarcoma ; Tumors</subject><ispartof>Journal of Egyptian National Cancer Institute, 2023-12, Vol.35 (1), p.30-6, Article 30</ispartof><rights>The Author(s) 2023</rights><rights>COPYRIGHT 2023 Springer</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c480t-b9b2b6b47b421845f3f7614a783636542899c49798c8d33dffb523940d9773603</cites><orcidid>0000-0001-6148-1643</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids></links><search><creatorcontrib>Amer, Hatem Wael</creatorcontrib><creatorcontrib>Algadi, Hana’a Hezam</creatorcontrib><creatorcontrib>Hamza, Shyma’a Ahmed</creatorcontrib><title>Mandibular small cell osteosarcoma: a case report and review of literature</title><title>Journal of Egyptian National Cancer Institute</title><addtitle>J Egypt Natl Canc Inst</addtitle><description>Background
Small cell osteosarcoma is an extremely rare histopathological variant of conventional osteosarcoma. Due to nonspecific symptoms, most osteosarcomas of the jaws are misdiagnosed as periapical abscesses and mistreated by teeth extraction and drainage.
Case presentation
We report, to our knowledge, the seventh case of small cell osteosarcoma in gnathic sites affecting the mandible of an old female with history of a large painful swelling related to the right mandibular molar area for 2 months. Cone-beam computed tomography scan showed an osteolytic lesion related to the lower molar area with involvement of the inferior alveolar nerve. An incisional biopsy was taken, and after histopathological examination and immunohistochemical staining, a diagnosis of small cell osteosarcoma was reached. Hemi-mandibulectomy was performed by a maxillofacial surgeon. No clinical evidence for recurrence was noted until manuscript writing.
Conclusion
Accurate diagnosis is very important, and general practitioners should be aware of this entity considering that small cell osteosarcoma has a poor prognosis when compared to conventional osteosarcoma.</description><subject>Biopsy</subject><subject>Bone cancer</subject><subject>Bone tumors</subject><subject>Bones</subject><subject>Case report</subject><subject>Case Reports</subject><subject>Cells</subject><subject>Chemotherapy</subject><subject>Cytoplasm</subject><subject>Ewings sarcoma</subject><subject>Immunohistochemistry</subject><subject>Jaw</subject><subject>Jaws neoplasms</subject><subject>Lymphoma</subject><subject>Mandibular osteosarcoma</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastasis</subject><subject>Oncology</subject><subject>Osteosarcoma</subject><subject>Proteins</subject><subject>Radiation therapy</subject><subject>Sarcoma</subject><subject>Small cell osteosarcoma</subject><subject>Tumors</subject><issn>2589-0409</issn><issn>1110-0362</issn><issn>2589-0409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNp9kV1LHTEQhpdSodb6B7xa6PXq5GPz0TuRfiiKN3odkuzkkMPu5jTZ09J_b-qKVigSmAzD-7zM8DbNCYFTQpQ4K5wBFx1Q1gEQTTr6rjmkvdIdcNDv_-k_NB9L2QIIAbI_bK5u7DxEtx9tbstkx7H1WEsqC6Zis0-T_dLa1tuCbcZdyktbgdr-ivi7TaEd44LZLvuMn5qDYMeCx0__UXP_7evdxY_u-vb75cX5dee5gqVz2lEnHJeOU6J4H1iQgnArFRNM9JwqrT3XUiuvBsaGEFxPmeYwaCmZAHbUXK6-Q7Jbs8txsvmPSTaax0HKG2PzEv2IxklvUWsgg2Dc-0EFR0EjRdCAxIXq9Xn12uX0c49lMdu0z3Nd31AleqGkJvJFtbHVNM4hLdn6KRZvzqXoJRUgVFWd_kdV34BT9GnGEOv8FUBXwOdUSsbwfAwB8zdWs8ZqaqzmMVZDK8RWqFTxvMH8svEb1AMk9aH5</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Amer, Hatem Wael</creator><creator>Algadi, Hana’a Hezam</creator><creator>Hamza, Shyma’a Ahmed</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6148-1643</orcidid></search><sort><creationdate>20231201</creationdate><title>Mandibular small cell osteosarcoma: a case report and review of literature</title><author>Amer, Hatem Wael ; Algadi, Hana’a Hezam ; Hamza, Shyma’a Ahmed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-b9b2b6b47b421845f3f7614a783636542899c49798c8d33dffb523940d9773603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biopsy</topic><topic>Bone cancer</topic><topic>Bone tumors</topic><topic>Bones</topic><topic>Case report</topic><topic>Case Reports</topic><topic>Cells</topic><topic>Chemotherapy</topic><topic>Cytoplasm</topic><topic>Ewings sarcoma</topic><topic>Immunohistochemistry</topic><topic>Jaw</topic><topic>Jaws neoplasms</topic><topic>Lymphoma</topic><topic>Mandibular osteosarcoma</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastasis</topic><topic>Oncology</topic><topic>Osteosarcoma</topic><topic>Proteins</topic><topic>Radiation therapy</topic><topic>Sarcoma</topic><topic>Small cell osteosarcoma</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amer, Hatem Wael</creatorcontrib><creatorcontrib>Algadi, Hana’a Hezam</creatorcontrib><creatorcontrib>Hamza, Shyma’a Ahmed</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of Egyptian National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amer, Hatem Wael</au><au>Algadi, Hana’a Hezam</au><au>Hamza, Shyma’a Ahmed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mandibular small cell osteosarcoma: a case report and review of literature</atitle><jtitle>Journal of Egyptian National Cancer Institute</jtitle><stitle>J Egypt Natl Canc Inst</stitle><date>2023-12-01</date><risdate>2023</risdate><volume>35</volume><issue>1</issue><spage>30</spage><epage>6</epage><pages>30-6</pages><artnum>30</artnum><issn>2589-0409</issn><issn>1110-0362</issn><eissn>2589-0409</eissn><abstract>Background
Small cell osteosarcoma is an extremely rare histopathological variant of conventional osteosarcoma. Due to nonspecific symptoms, most osteosarcomas of the jaws are misdiagnosed as periapical abscesses and mistreated by teeth extraction and drainage.
Case presentation
We report, to our knowledge, the seventh case of small cell osteosarcoma in gnathic sites affecting the mandible of an old female with history of a large painful swelling related to the right mandibular molar area for 2 months. Cone-beam computed tomography scan showed an osteolytic lesion related to the lower molar area with involvement of the inferior alveolar nerve. An incisional biopsy was taken, and after histopathological examination and immunohistochemical staining, a diagnosis of small cell osteosarcoma was reached. Hemi-mandibulectomy was performed by a maxillofacial surgeon. No clinical evidence for recurrence was noted until manuscript writing.
Conclusion
Accurate diagnosis is very important, and general practitioners should be aware of this entity considering that small cell osteosarcoma has a poor prognosis when compared to conventional osteosarcoma.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43046-023-00191-2</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-6148-1643</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2589-0409 |
| ispartof | Journal of Egyptian National Cancer Institute, 2023-12, Vol.35 (1), p.30-6, Article 30 |
| issn | 2589-0409 1110-0362 2589-0409 |
| language | eng |
| recordid | cdi_proquest_journals_2865687917 |
| source | DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Biopsy Bone cancer Bone tumors Bones Case report Case Reports Cells Chemotherapy Cytoplasm Ewings sarcoma Immunohistochemistry Jaw Jaws neoplasms Lymphoma Mandibular osteosarcoma Medicine Medicine & Public Health Metastasis Oncology Osteosarcoma Proteins Radiation therapy Sarcoma Small cell osteosarcoma Tumors |
| title | Mandibular small cell osteosarcoma: a case report and review of literature |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T11%3A03%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mandibular%20small%20cell%20osteosarcoma:%20a%20case%20report%20and%20review%20of%20literature&rft.jtitle=Journal%20of%20Egyptian%20National%20Cancer%20Institute&rft.au=Amer,%20Hatem%20Wael&rft.date=2023-12-01&rft.volume=35&rft.issue=1&rft.spage=30&rft.epage=6&rft.pages=30-6&rft.artnum=30&rft.issn=2589-0409&rft.eissn=2589-0409&rft_id=info:doi/10.1186/s43046-023-00191-2&rft_dat=%3Cgale_doaj_%3EA765726068%3C/gale_doaj_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2865687917&rft_id=info:pmid/&rft_galeid=A765726068&rft_doaj_id=oai_doaj_org_article_b7cae9901d634ccd8fb209e2e090e1bf&rfr_iscdi=true |