Emission‐Tunable Nanofluorophores through Self‐assembly of Amphiphilic Block Copolymers: toward Application in Cell Imaging
Comprehensive Summary Nanofluorophores based on aggregation‐induced emission (AIE) dyes have recently received considerable attention because of their unique optical properties and biocompatibility. In this work, we report an emission‐tunable nanofluorophore constructed by the self‐assembly of an am...
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| Veröffentlicht in: | Chinese journal of chemistry 2023-04, Vol.41 (8), p.931-938 |
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| container_title | Chinese journal of chemistry |
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| creator | Zhang, Shensong Qi, Shuang He, Xiongfei Xu, Pan Song, Bo |
| description | Comprehensive Summary
Nanofluorophores based on aggregation‐induced emission (AIE) dyes have recently received considerable attention because of their unique optical properties and biocompatibility. In this work, we report an emission‐tunable nanofluorophore constructed by the self‐assembly of an amphiphilic block copolymer (denoted by PTN). The diblock copolymer was synthesized by RAFT polymerization. A polyethylene glycol‐based trithiocarbonate was employed as the macromolecular chain transfer agent, and a near‐infrared emitting tetraphenylethylene derivative with a vinyl terminal group was designed as the monomer. The block copolymers self‐assembled in an aqueous solution to form nanospheres, which showed near‐infrared emission at approximately 720 nm with a significant Stokes shift of approximately 260 nm. Furthermore, nanofluorophores have excellent biocompatibility, photostability, and pH‐independent emission‐tunable properties, and were successfully applied to label HeLa cells for fluorescence imaging.
The diblock copolymers formed spherical nanoparticles through flash precipitation, which showed fluorescence emission at approximately 720 nm and a significant Stokes shift of approximately 260 nm. The nanoparticles were successfully applied to label HeLa cells for fluorescence imaging. |
| doi_str_mv | 10.1002/cjoc.202200748 |
| format | Article |
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Nanofluorophores based on aggregation‐induced emission (AIE) dyes have recently received considerable attention because of their unique optical properties and biocompatibility. In this work, we report an emission‐tunable nanofluorophore constructed by the self‐assembly of an amphiphilic block copolymer (denoted by PTN). The diblock copolymer was synthesized by RAFT polymerization. A polyethylene glycol‐based trithiocarbonate was employed as the macromolecular chain transfer agent, and a near‐infrared emitting tetraphenylethylene derivative with a vinyl terminal group was designed as the monomer. The block copolymers self‐assembled in an aqueous solution to form nanospheres, which showed near‐infrared emission at approximately 720 nm with a significant Stokes shift of approximately 260 nm. Furthermore, nanofluorophores have excellent biocompatibility, photostability, and pH‐independent emission‐tunable properties, and were successfully applied to label HeLa cells for fluorescence imaging.
The diblock copolymers formed spherical nanoparticles through flash precipitation, which showed fluorescence emission at approximately 720 nm and a significant Stokes shift of approximately 260 nm. The nanoparticles were successfully applied to label HeLa cells for fluorescence imaging.</description><identifier>ISSN: 1001-604X</identifier><identifier>EISSN: 1614-7065</identifier><identifier>DOI: 10.1002/cjoc.202200748</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH & Co. KGaA</publisher><subject>Addition polymerization ; Aggregation‐induced emission ; Aqueous solutions ; Biocompatibility ; Block copolymers ; Chain transfer ; Copolymers ; Emissions ; Fluorescence ; Fluorescent probes ; Macromolecules ; Molecular chains ; Nanoparticles ; Nanospheres ; Near infrared radiation ; Optical properties ; Polyethylene glycol ; Self-assembly ; Twisted intramolecular charge transfer</subject><ispartof>Chinese journal of chemistry, 2023-04, Vol.41 (8), p.931-938</ispartof><rights>2023 SIOC, CAS, Shanghai, & WILEY‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3178-791aec9079db0c6ec2eced536f51f46d0ac31c96a92f510d7d9ad842a07b19043</citedby><cites>FETCH-LOGICAL-c3178-791aec9079db0c6ec2eced536f51f46d0ac31c96a92f510d7d9ad842a07b19043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcjoc.202200748$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcjoc.202200748$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids></links><search><creatorcontrib>Zhang, Shensong</creatorcontrib><creatorcontrib>Qi, Shuang</creatorcontrib><creatorcontrib>He, Xiongfei</creatorcontrib><creatorcontrib>Xu, Pan</creatorcontrib><creatorcontrib>Song, Bo</creatorcontrib><title>Emission‐Tunable Nanofluorophores through Self‐assembly of Amphiphilic Block Copolymers: toward Application in Cell Imaging</title><title>Chinese journal of chemistry</title><description>Comprehensive Summary
Nanofluorophores based on aggregation‐induced emission (AIE) dyes have recently received considerable attention because of their unique optical properties and biocompatibility. In this work, we report an emission‐tunable nanofluorophore constructed by the self‐assembly of an amphiphilic block copolymer (denoted by PTN). The diblock copolymer was synthesized by RAFT polymerization. A polyethylene glycol‐based trithiocarbonate was employed as the macromolecular chain transfer agent, and a near‐infrared emitting tetraphenylethylene derivative with a vinyl terminal group was designed as the monomer. The block copolymers self‐assembled in an aqueous solution to form nanospheres, which showed near‐infrared emission at approximately 720 nm with a significant Stokes shift of approximately 260 nm. Furthermore, nanofluorophores have excellent biocompatibility, photostability, and pH‐independent emission‐tunable properties, and were successfully applied to label HeLa cells for fluorescence imaging.
The diblock copolymers formed spherical nanoparticles through flash precipitation, which showed fluorescence emission at approximately 720 nm and a significant Stokes shift of approximately 260 nm. The nanoparticles were successfully applied to label HeLa cells for fluorescence imaging.</description><subject>Addition polymerization</subject><subject>Aggregation‐induced emission</subject><subject>Aqueous solutions</subject><subject>Biocompatibility</subject><subject>Block copolymers</subject><subject>Chain transfer</subject><subject>Copolymers</subject><subject>Emissions</subject><subject>Fluorescence</subject><subject>Fluorescent probes</subject><subject>Macromolecules</subject><subject>Molecular chains</subject><subject>Nanoparticles</subject><subject>Nanospheres</subject><subject>Near infrared radiation</subject><subject>Optical properties</subject><subject>Polyethylene glycol</subject><subject>Self-assembly</subject><subject>Twisted intramolecular charge transfer</subject><issn>1001-604X</issn><issn>1614-7065</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqFkM9Kw0AQxoMoWKtXzwueU2c3yW7irQb_VIo9WMFb2Gw2TeomG3cbSk76CD6jT-KWih6FgRlmft988HneOYYJBiCXYq3FhAAhACyMD7wRpjj0GdDo0M0A2KcQvhx7J9auHc8YoSPv_aapra11-_XxuexbniuJHnmrS9Vro7tKG2nRpjK6X1XoSarScdxa2eRqQLpE06araleqFuhaafGKUt1pNTTS2Cu00VtuCjTtOnfnG2eD6halUik0a_iqblen3lHJlZVnP33sPd_eLNN7f764m6XTuS8CzGKfJZhLkQBLihwElYJIIYsooGWEy5AWwB0nEsoT4jZQsCLhRRwSDizHCYTB2LvY_-2Mfuul3WRr3ZvWWWYkpkHMgggTR032lDDaWiPLrDN1w82QYch2IWe7kLPfkJ0g2Qu2tZLDP3SWPizSP-035QCFQQ</recordid><startdate>20230415</startdate><enddate>20230415</enddate><creator>Zhang, Shensong</creator><creator>Qi, Shuang</creator><creator>He, Xiongfei</creator><creator>Xu, Pan</creator><creator>Song, Bo</creator><general>WILEY‐VCH Verlag GmbH & Co. KGaA</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20230415</creationdate><title>Emission‐Tunable Nanofluorophores through Self‐assembly of Amphiphilic Block Copolymers: toward Application in Cell Imaging</title><author>Zhang, Shensong ; Qi, Shuang ; He, Xiongfei ; Xu, Pan ; Song, Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3178-791aec9079db0c6ec2eced536f51f46d0ac31c96a92f510d7d9ad842a07b19043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Addition polymerization</topic><topic>Aggregation‐induced emission</topic><topic>Aqueous solutions</topic><topic>Biocompatibility</topic><topic>Block copolymers</topic><topic>Chain transfer</topic><topic>Copolymers</topic><topic>Emissions</topic><topic>Fluorescence</topic><topic>Fluorescent probes</topic><topic>Macromolecules</topic><topic>Molecular chains</topic><topic>Nanoparticles</topic><topic>Nanospheres</topic><topic>Near infrared radiation</topic><topic>Optical properties</topic><topic>Polyethylene glycol</topic><topic>Self-assembly</topic><topic>Twisted intramolecular charge transfer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Shensong</creatorcontrib><creatorcontrib>Qi, Shuang</creatorcontrib><creatorcontrib>He, Xiongfei</creatorcontrib><creatorcontrib>Xu, Pan</creatorcontrib><creatorcontrib>Song, Bo</creatorcontrib><collection>CrossRef</collection><jtitle>Chinese journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Shensong</au><au>Qi, Shuang</au><au>He, Xiongfei</au><au>Xu, Pan</au><au>Song, Bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Emission‐Tunable Nanofluorophores through Self‐assembly of Amphiphilic Block Copolymers: toward Application in Cell Imaging</atitle><jtitle>Chinese journal of chemistry</jtitle><date>2023-04-15</date><risdate>2023</risdate><volume>41</volume><issue>8</issue><spage>931</spage><epage>938</epage><pages>931-938</pages><issn>1001-604X</issn><eissn>1614-7065</eissn><abstract>Comprehensive Summary
Nanofluorophores based on aggregation‐induced emission (AIE) dyes have recently received considerable attention because of their unique optical properties and biocompatibility. In this work, we report an emission‐tunable nanofluorophore constructed by the self‐assembly of an amphiphilic block copolymer (denoted by PTN). The diblock copolymer was synthesized by RAFT polymerization. A polyethylene glycol‐based trithiocarbonate was employed as the macromolecular chain transfer agent, and a near‐infrared emitting tetraphenylethylene derivative with a vinyl terminal group was designed as the monomer. The block copolymers self‐assembled in an aqueous solution to form nanospheres, which showed near‐infrared emission at approximately 720 nm with a significant Stokes shift of approximately 260 nm. Furthermore, nanofluorophores have excellent biocompatibility, photostability, and pH‐independent emission‐tunable properties, and were successfully applied to label HeLa cells for fluorescence imaging.
The diblock copolymers formed spherical nanoparticles through flash precipitation, which showed fluorescence emission at approximately 720 nm and a significant Stokes shift of approximately 260 nm. The nanoparticles were successfully applied to label HeLa cells for fluorescence imaging.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH & Co. KGaA</pub><doi>10.1002/cjoc.202200748</doi><tpages>8</tpages></addata></record> |
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| subjects | Addition polymerization Aggregation‐induced emission Aqueous solutions Biocompatibility Block copolymers Chain transfer Copolymers Emissions Fluorescence Fluorescent probes Macromolecules Molecular chains Nanoparticles Nanospheres Near infrared radiation Optical properties Polyethylene glycol Self-assembly Twisted intramolecular charge transfer |
| title | Emission‐Tunable Nanofluorophores through Self‐assembly of Amphiphilic Block Copolymers: toward Application in Cell Imaging |
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