Synthesis of tricyclic and tetracyclic benzocycloheptane derivatives linked morpholine moiety as CDK2 inhibitors

With the aim of developing cyclin‐dependent kinase 2 (CDK2) inhibitors with strong antibreast cancer efficacy, new tricyclic and tetracyclic benzo[6,7]cycloheptane derivatives were synthesized. The newly synthesized tri‐ and tetracyclic derivatives were achieved from the reaction of 4‐(4‐morpholin‐4...

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Veröffentlicht in:	Drug development research 2023-09, Vol.84 (6), p.1127-1141
Hauptverfasser:	Farghaly, Thoraya A, Abbas, Eman M H, Mariam A Al‐Sheikh, Medrasi, Hanadi Y, Masaret, Ghada S, Rami Adel Pashameah, Qurban, Jihan, Harras, Marwa F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Anticancer properties Apoptosis Cancer Cell cycle Cell death Cyclin-dependent kinase 2 Doxorubicin Inhibitors Kinases Roscovitine S phase Tumor cell lines
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