Chitosan-coating strategies on the development of targeted chemodrug delivery nanosystem with titania nanotube arrays

This study investigates Cisplatin (CDDP)—titania nanotube arrays (TNA) encapsulation efficiency in terms of chitosan-coating strategies including coating methods, coating layers, biocompatibility, and CDDP release in various stimulated model systems. Characterization was performed using field emission scanning electron microscopy, energy-dispersive X-ray, X-ray diffraction, ion-coupled plasma-optical emission spectrometry, fourier transform infrared spectroscopy, and spectrophotometry. The results demonstrated efficient biocompatible loading of CDDP onto a TNA nanosystem using the top-filling method, with an encapsulation efficiency of 98.95 ± 7.02%. This was confirmed by ICP-OES, which detected platinum (Pt) ions for up to ten days. The nanosystem successfully enabled long-term sustained release of CDDP in various stimulated model systems, establishing an effective in vitro targeted cancer therapy model. Further investigation using in vivo models is necessary to validate the findings of this study, particularly in the context of targeted cancer therapy applications. Graphical abstract An illustrative description of the present work. The image depicts the workflow in detail on CDDP-loadedTNA (CDDP-TNA)-coating strategies with biopolymer chitosan and CDDP delivery efficiency,especially in prolonged sustained release system targeted for cancer treatment application.