Small molecule kinase inhibitors enhance aminolevulinic acid-mediated protoporphyrin IX fluorescence and PDT response in triple negative breast cancer cell lines

Significance: We demonstrate that clinically used kinase inhibitors such as lapatinib can be used for enhancing aminolevulinic acid (ALA) for tumor fluorescence imaging and photodynamic therapy (PDT). Aim: ALA is used as a prodrug for protoporphyrin IX (PpIX) fluorescence-guided tumor resection and...

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Veröffentlicht in:	Journal of biomedical optics 2021-09, Vol.26 (9), p.098002-098002
Hauptverfasser:	Palasuberniam, Pratheeba, Kraus, Daniel, Mansi, Matthew, Howley, Richard, Braun, Alexander, Myers, Kenneth A, Chen, Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminolevulinic acid Aminolevulinic Acid - pharmacology Antibiotics Apoptosis Brain cancer Breast cancer Cancer therapies Cell culture Cell Line, Tumor Confocal microscopy Cytotoxicity Efflux Enzyme inhibitors Epithelial cells Epithelium Flow cytometry Fluorescence Fluorescence spectroscopy Gefitinib Humans Inhibitors Kinases Lasers Mitochondria Photochemotherapy Photodynamic therapy Photosensitizing Agents - pharmacology Protoporphyrin Protoporphyrin IX Protoporphyrins Surgery Therapeutic Triple Negative Breast Neoplasms - diagnostic imaging Triple Negative Breast Neoplasms - drug therapy Tumor cell lines Tumor cells Tumors
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